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Cerus Initiates Two Phase III Clinical Trials for the INTERCEPT Blood System for RBCs
Cerus has initiated patient enrollment in two European Phase III clinical trials for the INTERCEPT System for red blood cells (RBCs) to support CE Mark registration. One trial is being conducted for patients with acute anemia, and a separate trial is being conducted for patients with chronic anemia. “This Cerus milestone marks an important step in our effort to provide pathogen inactivation for RBCs, complementing the INTERCEPT Blood Systems for platelets and plasma that are currently available in Europe and other geographies,” said Dr. Laurence Corash, Cerus’ chief medical officer. “We anticipate that the future availability of pathogen inactivation for all three blood components will allow patients receiving transfusions to realize the full benefit of the prospective protection it can provide.”
Read more about Cerus’ Phase III Clinical Trials for RBCs
First Danish Hospital Signs INTERCEPT Platelet Agreement with Cerus
Aalborg University Hospital in Denmark signed a five year project collaboration agreement for the INTERCEPT Blood System for platelets. The first hospital in Denmark to adopt INTERCEPT, the department of FBE Klinisk Immunologi at Aalborg University Hospital supplies an estimated 3,000 platelet units annually to Region Nordjylland, representing approximately 10% of Denmark’s platelet market. “Bacterial contamination of platelets is one of the most prevalent infectious risks in blood transfusion, posing serious health risks to transfusion patients. We believe the INTERCEPT Blood System will significantly decrease residual risk due to bacterial contamination, provide a proactive defense against emerging pathogens, and offer key operational advantages such as reduced waste rates,” stated Dr. Kim Varming of the department of FBE Klinisk Immunologi.
Read the Press Release
Cerus' ISBT Symposium Video Replay is Now Available
If you missed the scientific symposium at ISBT Amsterdam or just wish to watch it again, the video replay is now available online.
Evolving Challenges and Technologies to Safeguard the Blood Supply
The role of pathogen inactivation in today’s changing regulatory and blood testing landscape
Safeguarding the blood supply as it relates to the minimization of bacterial contamination, as well as donor deferral policies used to contain the spread of emerging pathogens, are significant challenges faced by blood centers and hospitals today. This workshop explores such challenges, including current detection technologies, and the potential impact that pathogen inactivation might have on policies and methodologies. The discussion features the INTERCEPT Blood System, the pathogen inactivation system that has been proven through 10 years of routine use, with almost 2 million transfusion products treated in over 100 centers throughout Europe, and selected countries in other regions around the world.
Speakers & Topics:
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ADDRESSING THE RISK OF BACTERIAL CONTAMINATION IN PLATELETS
Dr. Steven Kleinman (Canada), Chair
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THE PREDICTED EFFECTS OF PATHOGEN INACTIVATION ADOPTION ON CURRENT PRACTICES TO ENSURE BLOOD SAFETY
Dr. Susan Stramer (USA)
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A DECADE OF BLOOD SAFETY THROUGH ROUTINE USE OF PATHOGEN INACTIVATION IN BLOOD CENTERS
Dr. Jean-Pierre Cazenave (France)
Watch the video replay
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Ask the Expert...
Nina Mufti, PhD
Vice President, Development, Cerus Corporation |
Q: How is blood transfusion used in the treatment of chronic anemia patients?
A: Chronic anemia patients such as those with hemoglobinopathies like sickle cell disease (SCD) and thalassemia suffer from blood disorders that affect oxygen transport in the body. These diseases are lifelong, systemic disorders that may present challenges across organs including the brain, spleen, heart, and lungs. Five to ten percent of SCD patients are transfusion dependent, as are many thalassemia major patients, necessitating regular (~monthly) RBC transfusions. Life-long transfusion therapy makes for continuous exposure to RBCs from multiple donors. Indeed, these patients are exposed to more blood transfusions than almost any other patient group, receiving as many as 1,500 RBC units over the course of a lifetime. In addition to iron accumulation that may result from chronic RBC transfusions, these patients are at elevated risk for exposure to existing and emerging pathogens and to bacterial contamination.
Learn more about Sickle Cell Disease and Thalassemia
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