Researchers found that comparing the levels of two molecules in the brain detected with a form of MRI scanning was able to reliably predict MS progression in two independent groups of people with MS. With further study, this may be a useful tool for tracking the benefits of potential treatments in clinical trials aimed at protecting the nervous system from damage. Sara Llufriu, MD, PhD (Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain) and Daniel Pelletier, MD (Yale University) and colleagues from the University of California-San Francisco report on the study in JAMA Neurology (2014;71(7):840-847). Dr. Pelletier was supported during this study by a Harry Weaver Neuroscience Fellowship from the National MS Society.

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National MS Society - July 23, 2014

A team funded by the National MS Society has shed new light on immune cells known as macrophages, and how one type of these cells may play a significant role in launching damage in MS. The researchers have discovered a way to differentiate between good and bad types of these immune cells active during MS-like disease in mice, and if further research shows that these findings hold true for people with MS, this opens up possibilities for developing therapies that target the bad cells and spare the good cells. Richard Ransohoff, MD, Ryo Yamasaki, MD, PhD (Cleveland Clinic Foundation) and colleagues report their findings in The Journal of Experimental Medicine (published online July 7, 2014).

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National MS Society - July 21, 2014

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