Systemic treatment for blepharokeratoconjunctivitis in children Authors' conclusions: There is currently no evidence from clinical trials regarding the safety and efficacy of systemic treatments for BKC. Trials are required to test efficacy and safety of current and future treatments. Outcome measures need to be developed which can capture both objective clinical and patient-reported aspects of the condition and treatments.
Nutritional support for critically ill children Authors' conclusions: There was only one randomized trial relevant to the review question. Research is urgently needed to identify best practices regarding the timing and forms of nutrition for critically ill infants and children.
Intravenous magnesium sulfate for treating children with acute asthma in the emergency department Authors' conclusions: IV MgSO4 may reduce the need for hospital admission in children presenting to the ED with moderate to severe exacerbations of asthma, but the evidence is extremely limited by the number and size of studies. Few side effects of the treatment were reported, but the data were extremely limited
Drugs for the acute treatment of migraine in children and adolescents Authors' conclusions: Low quality evidence from two small trials shows that ibuprofen appears to improve pain freedom for the acute treatment of children with migraine. We have only limited information on adverse events associated with ibuprofen in the trials included in this review. Triptans as a class are also effective at providing pain freedom in children and adolescents but are associated with higher rates of minor adverse events. Sumatriptan plus naproxen sodium is also effective in treating adolescents with migraine.
Dynamed Point-of- Care Clinical Reference Tool
Ulcerative colitis
Positive C-reactive protein and albumin tests may each help detect inflammatory bowel disease in children and young adults with chronic gastrointestinal symptoms referred for endoscopy (Pediatrics 2016 Jan)
Rehydration therapy in children
Half-strength apple juice may reduce need for IV rehydration compared to electrolyte maintenance solution in children with mild gastroenteritis and at most mild dehydration (JAMA 2016 Apr 30)
Missed opportunities: a review of recent evidence into children and young people's mental health. Based on the most recent high quality research, this report breaks down findings into four age groups: pregnancy to age 4; children aged 5-10, 11-15 year olds, and young adults aged 16-25. For all age groups, a dominant issue has been the persistent gap between children’s needs and their access to help and support, especially early on when difficulties with mental health first emerge.
NHS Behind The Headlines - Media stories explained
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