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Stroke Evidence Update

4th July 2016

Do you have any research needs? Please contact your Stroke Librarian, Pip Divall on 0116 250 2309 or  Pip.Divall@uhl-tr.nhs.uk
Transcervical extracorporeal reverse flow neuroprotection for reducing the risk of stroke during carotid artery stenting
New and Updated Cochrane Systematic Reviews

Speech and language therapy for aphasia following stroke
Authors' conclusions: Our review provides evidence of the effectiveness of SLT for people with aphasia following stroke in terms of improved functional communication, reading, writing, and expressive language compared with no therapy. There is some indication that therapy at high intensity, high dose or over a longer period may be beneficial. HIgh-intensity and high dose interventions may not be acceptable to all.


Cochrane Clinical Answers

Does electromechanical and robot-assisted arm training improve generic activities of daily living, arm function and muscle strength in people who have had a stroke?

How do colloid and crystalloid parenteral fluids compare in people with acute stroke?

Can peroxisome proliferator-activated receptor gamma agonists help to prevent recurrent stroke and other vascular events?

How does adding buflomedil to usual care affect outcomes in people with acute ischemic stroke?
Antiplatelet agents for secondary prevention of stroke
Ticagrelor may not reduce composite risk of stroke, myocardial infarction, or death compared to aspirin in patients with acute ischemic stroke or transient ischemic attack (N Engl J Med 2016 May 10).

Atrial fibrillation
Higher levels of interleukin 6 or C-reactive protein associated with increased risk of all-cause mortality in patients with atrial fibrillation receiving oral anticoagulation therapy (Heart 2016 Apr 1)
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Other High Quality Research

Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial.

Scientific Rationale for the Inclusion and Exclusion Criteria for Intravenous Alteplase in Acute Ischemic Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association.

Test Accuracy of Informant-Based Cognitive Screening Tests for Diagnosis of Dementia and Multidomain Cognitive Impairment in Stroke.

Obesity and postoperative atrial fibrillation in patients undergoing cardiac surgery: Systematic review and meta-analysis.

Alteplase Treatment in Acute Stroke: Incorporating Food and Drug Administration Prescribing Information into Existing Acute Stroke Management Guide.

Paroxysmal Atrial Fibrillation: Novel Strategies for Monitoring and Implications for Treatment in Stroke.

Role of echocardiography in patients with stroke.

Mechanical Thrombectomy in Acute Ischemic Stroke: A Systematic Review.

Effect of stem cell-based therapy for ischemic stroke treatment: A meta-analysis.

The role of CHADS2 and CHA2 DS2 -VASc scores in the prediction of stroke in individuals without atrial fibrillation: a population-based study.

Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack.
 

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Leicester Publications 
Meta-analysis of Vascular Imaging Features to Predict Outcome Following Intravenous rtPA for Acute Ischemic Stroke.
UpToDate
Stroke prevention in sickle cell disease
NHS Behind the Headlines - media stories explained

Study: 'mini strokes should be treated immediately with aspirin'
Table of Contents

Cerebrovascular Diseases
Experimental & Translational Stroke Medicine
International Journal of Stroke
Journal of Stroke & Cerebrovascular Diseases
Stroke
Stroke Research and Treatment
Our mailing address is: pip.divall@uhl-tr.nhs.uk
 
Copyright © 2016 UHL Clinical Librarian Service, All rights reserved.
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UHL Clinical Librarian Service · Education Centre · University Hospitals Leicester · Leicester, LE3 9QP · United Kingdom

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