Luteinising hormone releasing hormone (LHRH) agonists for the treatment of relapsed epithelial ovarian cancer Authors' conclusions: Based on this review of two small RCTs, there is not enough evidence to comment on the safety and effectiveness of LHRH agonists in the treatment of platinum-refractory and platinum-resistant (relapsed) EOC. Overall, the quality of evidence for all outcomes (including OS, PFS, QoL and adverse events) is very low.
Radiotherapy for diffuse brainstem glioma in children and young adults Authors' conclusions: We could make no definitive conclusions from this review based on the currently available evidence. Further research is needed to establish the role of radiotherapy in the management of newly diagnosed diffuse brainstem glioma in children and young adults. Future RCTs should be conducted with adequate power and all relevant outcomes should be taken into consideration. Moreover, international multicentre collaboration is encouraged. Considering the potential advantage of hypofractionated radiotherapy to decrease the treatment burden and increase the quality of remaining life, we suggest that more attention should be paid to hypofractionated radiotherapy.
risk of perforation < 1 and major bleeding < 2 per 10,000 procedures in adults having flexible sigmoidoscopy screening (but higher rates in follow-up colonoscopies) (JAMA 2016 Jun 21)
flexible sigmoidoscopy screening reduces colorectal cancer-related mortality and colorectal cancer incidence in adults (USPSTF Jun 2016)
review of benefits, burden, and harms of screening based on mathematical modeling simulations (JAMA 2016 Jun 21)
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