UHL Colorectal Evidence Update July 2016

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Colorectal Surgery Evidence Update

12th July 2016

Suspected cancer

Complicated intra-abdominal infections: ceftolozane/tazobactam

Secca System for faecal incontinence

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Leicester Publications

Rectal cancers with microscopic circumferential resection margin involvement (R1 resections): Survivals, patterns of recurrence, and prognostic factors.

Oxaliplatin and 5-FU/folinic acid (modified FOLFOX6) with or without aflibercept in first-line treatment of patients with metastatic colorectal cancer: the AFFIRM study.

Circumferential resection margins and perineal complications after neoadjuvant long-course chemoradiotherapy followed by extralevator abdominoperineal excision of the rectum: Five years of activity at a single institution

Effectiveness of a care bundle to reduce surgical site infections in patients having open colorectal surgery.

Partial prostatectomy for anterior low rectal cancer: how to do it. A response to Frasson et al.

Flexible sigmoidoscopy for colorectal cancer screening

risk of perforation < 1 and major bleeding < 2 per 10,000 procedures in adults having flexible sigmoidoscopy screening (but higher rates in follow-up colonoscopies) (JAMA 2016 Jun 21)
flexible sigmoidoscopy screening reduces colorectal cancer-related mortality and colorectal cancer incidence in adults (USPSTF Jun 2016)
review of benefits, burden, and harms of screening based on mathematical modeling simulations (JAMA 2016 Jun 21)

New and Updated Cochrane Systematic Reviews

There were no new Cochrane Systematic Reviews this month

Other High Quality Research

Critical appraisal of laparoscopic vs open rectal cancer surgery.

Transanal total mesorectal excision (taTME) for rectal cancer: a systematic review and meta-analysis of oncological and perioperative outcomes compared with laparoscopic total mesorectal excision.

Platelet-to-lymphocyte ratio could be a promising prognostic biomarker for survival of colorectal cancer: a systematic review and meta-analysis.

Systematic review of tumour necrosis factor antagonists in extraintestinal manifestations in inflammatory bowel disease.

DNA methylation based biomarkers in colorectal cancer: A systematic review.

Diagnostic Accuracy of MRI for Assessment of T Category and Circumferential Resection Margin Involvement in Patients With Rectal Cancer: A Meta-Analysis.

Can GSTM1 and GSTT1 polymorphisms predict clinical outcomes of chemotherapy in gastric and colorectal cancers? A result based on the previous reports.

Optimum level of inferior mesenteric artery ligation for the left-sided colorectal cancer. Systematic review for high and low ligation continuum.

Sporadic colorectal cancer: microbial contributors to disease prevention, development and therapy

Endoscopic mucosal resection and endoscopic submucosal dissection for colorectal lesions: A systematic review.

Endoscopic treatments for rectal neuroendocrine tumors smaller than 16 mm: a meta-analysis.

Prognostic significance of preoperative prognostic nutritional index in colorectal cancer: results from a retrospective cohort study and a meta-analysis.

The effects of physical prehabilitation in elderly patients undergoing colorectal surgery: a systematic review.

Does neoadjuvant therapy increase the incidence of anastomotic leakage after anterior resection for mid and low rectal cancer? A systematic review and meta-analysis.

Systematic review of systemic adjuvant, neoadjuvant and perioperative chemotherapy for resectable colorectal-liver metastases.

Extralevator vs conventional abdominoperineal resection for rectal cancer-A systematic review and meta-analysis.

Other Sources

Public Health England - Health matters: improving the prevention and diagnosis of bowel cancer June 2016

National report shows inconsistent care for high-risk emergency bowel surgery

Simple bowel cancer home testing kit to be offered to all men and women aged 60 to 74.

Table of Contents

Clinical Colorectal Cancer
Colorectal Disease
Diseases of the Colon & Rectum
International Journal of Colorectal Disease
Seminars in Colon and Rectal Surgery

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UHL Clinical Librarian Service · Education Centre · Glenfield Hospital · Leicester, LE3 9QP · United Kingdom