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Schedule of Presentations
Saturday, October 17

1:00-1:15pm
Robustly dysregulated miRNAs downstream of MeCP2 control human prenatal brain development through differential effects on autism-related signaling pathways

1:15-1:30pm 
Characterization of a novel phosphorylation site of MeCP2 that might be involved in neuronal morphogenesis and chromatin related functions

1:30-1:45pm 
Aberrant astrocyte maturation contributes to Rett Syndrome pathogenesis

1:45-2:00pm 
To move or not to move: Is acetylated tubulin the answer For Rett Syndrome?

2:00-2:15pm 
Deficiency of MeCP2 in glutamatergic neurons leads to severe neurological dysfunctions caused by altered neuronal activity

2:15-2:30pm 
Impaired vocal perception in a mouse model of Rett syndrome is caused by abnormal plasticity of auditory cortical inhibitory circuits

2:30-2:45m
Role of MeCP2 in mitochondrial impairments and myelin defects

2:45-3:00pm 
A novel mGlu5 positive allosteric modulator improves phenotype and rescues synaptic plasticity defects in a mouse model of Rett syndrome
 

Sunday, October 18

9:15-9:30am
Lack of Mecp2 in the developing embryonic cortex delays the acquirement of mature neuronal identity

8:00am-12:00pm
MeCP2 regulates gene expression in dorsal root ganglia after peripheral nerve injury

8:00am-12:00pm
mGlu7 is critical for hippocampal plasticity and is a potential therapeutic target for the treatment of Rett Syndrome

8:00am-12:00pm
Novel applications of magnetic sorting to analyze cell-type specific gene and protein expression in a mouse model of Rett Syndrome

 

Tuesday, October 20

8:00am-12:00pm
Loss of MeCP2 in the rat uniquely models regression, impaired sociability, and transcriptional deficits of Rett syndrome

8:00am-12:00pm
Assessing the mecp2 (bird) model of rett syndrome across species, sex, and age

1:00-5:00pm
Excessive Ras-MAPK-dependent synaptic clustering drives enhanced motor learning in the MECP2-duplication mouse model of syndromic autism

1:00-5:00pm
Human and Mouse Models of Rett Syndrome exhibit altered prenatal cortical development due to alterations in neurogenesis

1:00-5:00pm
Increased binding of MeCP2 and DNMT1 to RELN and GAD1 regulatory regions is associated with down-regulation of RELN and GAD1 mRNAs in postmortem prefrontal cortex of autism spectrum disorder (ASD) brain

8:00am-12:00pm
Motor and behavioral phenotypes in a novel transgenic rat model of Rett Syndrome

1:00-5:00pm
The TrkB ligand LM22A-4 rescues hippocampal LTP and Rett-like behavioral phenotypes in Mecp2 knockout mice

1:00-5:00pm
Partial rescue of Rett syndrome phenotypes via modulation of NF-κB signaling and vitamin D supplementation in Mecp2-null mice

1:00-5:00pm
Chronic In vivo treatment of Rett mice with the free radical scavenger Trolox

1:00-5:00pm
CAGE analysis of genes involved in the onset of rett syndrome

1:00-5:00pm
Visual evoked potentials detect cortical processing deficits in Rett syndrome patients

1:00-5:00pm
Post-critical period Mecp2 de-silencing rescues aberrant visual circuits in a Rett syndrome mouse model

1:00-5:00pm
Loss of MeCP2 causes urological dysfunction and contributes to death by kidney failure in mouse models of Rett Syndrome

1:00-5:00pm
Neuron-microglia interaction contributes to Rett syndrome pathology

1:00-5:00pm
Misregulation of alternative splicing in a mouse model of Rett syndrome

1:00-5:00pm
Transcriptional profiling of Mecp2 A140V mouse model for Rett syndrome/X-linked mental retardation reveals subtle changes in long gene expression

1:00-5:00pm
Chronic forniceal deep brain stimulation recuses the impairment of contextual fear memory and hippocampal LTP in Rett syndrome mice

1:00-5:00pm
Consequences of hippocampal hyperactivity in the medial prefrontal cortex of Mecp2 knockout mice, a model of the autism Rett syndrome

1:00-5:00pm
Ketamine ameliorates visual evoked potential impairments in Mecp2 Heterozygous female mice

1:00-5:00pm
Neuronal hyperexcitability versus breathing abnormality in Mecp2-null mice

1:00-5:00pm
Alterations in MeCP2 dosage within dopaminergic neurons regulate startle and prepulse inhibition in mice

1:00-5:00pm
Increased GFAP levels accompany neuronal loss in a mouse model of MeCP2 duplication syndrome

1:00-5:00pm
Alterations in the novel object recognition circuit following MeCP2 deletion from cholinergic neurons

1:00-5:00pm
Bidirectional homeostatic synaptic plasticity is impaired in cultured hippocampal neurons from Mecp2 knockout mice

1:00-5:00pm
The balance between excitation and inhibition of cortical GABAergic interneurons is altered in both Mecp2 and Cdkl5 knockout mice

1:00-5:00pm
DNA methylation, neural stem cells and Fetal Alcohol Spectrum Disorders; implicating the role of MeCP2 regulatory network

1:00-5:00pm
Intracellular Ca2+ imaging revealed enhanced spiking activity in Mecp2 knockout neurons
 

Wednesday, October 21

8:00am-12:00pm
Regulation of nuclear microRNA processing by MeCP2 and impact on dendritic growth

1:55-2:15pm
Deficits in astrocyte mediate potassium homeostasis contribute to Rett Syndrome disease pathogenesis

 
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