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Hepatobiliary Evidence Update

03/12/2015

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Paclitaxel as albumin-bound nanoparticles in combination with gemcitabine for previously untreated metastatic pancreatic cancer

Ledipasvir–sofosbuvir for treating chronic hepatitis C

Living-donor liver transplantation

Daclatasvir for treating chronic hepatitis C

Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
New and Updated Cochrane Systematic Reviews

Stapler versus scalpel resection followed by hand-sewn closure of the pancreatic remnant for distal pancreatectomy
Authors' conclusions:
 The quality of evidence is moderate and mainly based on the high weight of the results of one multicentre RCT. Unfortunately, there are no other completed RCTs on this topic except for one relevant ongoing trial. Neither stapler nor scalpel resection followed by hand-sewn closure of the pancreatic remnant for distal pancreatectomy showed any benefit compared to the other method in terms of postoperative pancreatic fistula, overall postoperative mortality or operation time. Currently, the choice of closure is left up to the preference of the individual surgeon and the anatomical characteristics of the patient. Another (non-European) multicentre trial (e.g. with an equality or non-inferiority design) would help to corroborate the findings of this meta-analysis. Future trials assessing novel methods of stump closure should compare them either with stapler or hand-sewn closure as a control group to ensure comparability of results.
 
Other Good Quality Systematic Reviews

Diagnostic accuracy of serum squamous cell carcinoma antigen and squamous cell carcinoma antigen-immunoglobulin M for hepatocellular carcinoma: A meta-analysis

Prognostic value of Ki-67 in solid pseudopapillary tumor of the pancreas: Huashan experience and systematic review of the literature

Telomerase activity as a marker for differential diagnosis of pancreatic adenocarcinoma: a systematic review and meta-analysis

Systematic review of peri-operative nutritional support for patients undergoing hepatobiliary surgery

Association of recently described adipokines with liver histology in biopsy-proven non-alcoholic fatty liver disease: a systematic review

Pancreas-preserving management in reinterventions for severe pancreatic fistula after pancreatoduodenectomy: a systematic review

A Meta-Analysis and Systematic Review: Success of Extracorporeal Shock Wave Lithotripsy in Chronic Calcific Pancreatitis Management

Acute pancreatitis following adult liver transplantation: A systematic review

Antiviral therapy for chronic hepatitis B viral infection in adults: A systematic review and meta-analysis

Antiviral therapy in management of chronic hepatitis B viral infection in children: A systematic review and meta-analysis

Extranodal extension in N1-adenocarcinoma of the pancreas and papilla of Vater: a systematic review and meta-analysis of its prognostic significance

Effect of Antecolic versus Retrocolic Gastroenteric Reconstruction after Pancreaticoduodenectomy on Delayed Gastric Emptying: A Meta-Analysis of Six Randomized Controlled Trials

A systematic review and meta-analysis of feasibility, safety and efficacy of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) versus two-stage hepatectomy (TSH)

The Seroprevalence of Hepatitis C Antibodies in Immigrants and Refugees from Intermediate and High Endemic Countries: A Systematic Review and Meta-Analysis

Hyperuricemia and risk of nonalcoholic fatty liver disease: a systematic review and meta-analysis
Table of Contents

Alimentary Pharmacology and Therapeutics
American Journal of Gastroenterology
Clinical Gastroenterology and Hepatology
Endoscopy
Gastroenterology
Gastrointestinal Endoscopy
Gut
Hepatology
Journal of Gastroenterology
Journal of Hepatology
Nature Reviews Gastroenterology and Hepatology
Seminars in Liver Disease
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