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This installment of our Centre’s AMR Alert has been put together by NCCID’s Yoav Keynan MD, PhD.
One of two scientific leads for the Centre, Dr. Keynan is an Assistant Professor with the University of Manitoba in the Departments of Internal Medicine, Medical Microbiology and Community Health Sciences.
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“Exploring the evidence base for national and regional policy interventions to combat resistance”
The Lancet, Nov. 18, 2015
This article by Dar et al. explores the strength/weakness of evidence behind the impact of interventions, sustainability and the generalizability of approaches. This review highlights gaps in the evidence for choosing an optimal surveillance system (and there are a number to choose from), or for guiding responsible use and promoting infection control practices.
“Understanding the mechanisms and drivers of antimicrobial resistance”
The Lancet, Nov. 18, 2015
In their study, Holmes et al. review the reasons bacteria develop antimicrobial resistance, highlighting the fact that emergence of AMR is a natural, evolutionary response to antimicrobial exposure. The prevalence of antimicrobial-resistant microorganisms is impacted by human activities related to agriculture and environmental influences. The mechanisms of AMR, long-term persistence, and successful clonal spread are key for sustainable AMR strategies.
“Variability in Antibiotic Use Across Nursing Homes and the Risk of Antibiotic-Related Adverse Outcomes for Individual Residents”
JAMA Internal Medicine, Aug. 2015
This study shows the variability in antimicrobial agents in nursing homes across Canada. Daneman et al. find that understanding the reasons for variance is essential to harmonize and ensure the rationale for antimicrobials. Daneman’s work suggests that understanding and decreasing the inappropriate use of antimicrobials can improve outcomes in nursing homes.
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