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Colorectal Surgery Evidence Update

07/03/2016

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Therapeutic monitoring of TNF-alpha inhibitors in Crohn’s disease (LISA-TRACKER ELISA kits, IDKmonitor ELISA kits, and Promonitor ELISA kits)

Irritable bowel syndrome in adults

NICE Surveillance Decision: Colorectal cancer: diagnosis and management
New and Updated Cochrane Systematic Reviews

Irinotecan chemotherapy combined with fluoropyrimidines versus irinotecan alone for overall survival and progression-free survival in patients with advanced and/or metastatic colorectal cancer
Authors' conclusions: There was no overall survival benefit of the irinotecan and fluoropyrimidine treatment over irinotecan alone, thus both regimens remain reasonable options in treating patients with advanced or metastatic CRC. Given the low and moderate quality of the evidence, future studies with sufficient numbers of patients in each treatment arms are needed to clarify the benefit observed in progression-free survival with combination irinotecan and fluoropyrimidines.

Glutamine for induction of remission in Crohn's disease
Authors' conclusions: Currently there is insufficient evidence to allow firm conclusions regarding the efficacy and safety of glutamine for induction of remission in Crohn's disease. Data from two small studies suggest that glutamine supplementation may not be beneficial in active Crohn's disease but these results need to be interpreted with caution as they are based on small numbers of patients. This review highlights the need for adequately powered randomised controlled trials to investigate the efficacy and safety of glutamine for induction of remission in Crohn's disease.
Colonoscopy
Split-dose regimen of low-volume (2 L) PEG-ascorbate solution may increase adenoma detection and colon cleansing quality compared to single-dose regimen on evening before colonoscopy (Gut 2015 Dec 9 early online)

Colorectal cancer
ACR Appropriateness Criteria for radiologic management of hepatic malignancy (National Guideline Clearinghouse 2016 Feb 15)

Nitroglycerin Rectal Ointment
2015 American Geriatrics Society (AGS) Beers Criteria for potentially inappropriate medication use in older adults (J Am Geriatr Soc 2015 Nov)
Other Good Quality Systematic Reviews

Metastatic Colorectal Cancer: A Systematic Review of the Value of Current Therapies.

Can KRAS and BRAF mutations limit the benefit of liver resection in metastatic colorectal cancer patients? A systematic review and meta-analysis.

Role of the cold biopsy technique in diminutive and small colonic polyp removal: a systematic review and meta-analysis.

Diffusion-weighted Magnetic Resonance Enterography for Evaluating Bowel Inflammation in Crohn's Disease: A Systematic Review and Meta-analysis.

The Worse Prognosis of Right-Sided Compared with Left-Sided Colon Cancers: a Systematic Review and Meta-analysis.

Laparoscopic colorectal resection versus open colorectal resection in octogenarians: asystematic review and meta-analysis of safety and efficacy.

Systematic review with meta-analysis: diagnostic overlap of microscopic colitis and functionalbowel disorders.

Folic Acid Supplementation May Reduce Colorectal Cancer Risk in Patients With InflammatoryBowel Disease : A Systematic Review and Meta-Analysis.
Leicester Publications

Has patient knowledge of inflammatory bowel disease improved since 1999? 

An experimental model for ex vivo normothermic perfusion of isolated porcine small bowel segments
 
NHS Behind The Headlines - Media stories explained

Hope that blood test 'could diagnose five types of cancer'

Researchers investigate why obesity can trigger bowel cancer
Other Sources

Improving quality in IBD services Royal College of Physicians report: 16/02/2016

Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial.
Table of Contents

Clinical Colorectal Cancer
Colorectal Disease
Diseases of the Colon & Rectum
International Journal of Colorectal Disease
Seminars in Colon and Rectal Surgery
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