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Cardiac Surgery Evidence Update

5th May 2016

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Do you have any research needs? Please do contact your Cardiac Surgery Librarian, Keith Nockels for any information and research assistance. Keith can be contacted directly on 0116 258 5558 or via email at: keith.nockels@uhl-tr.nhs.uk
Normothermic extracorporeal preservation of hearts for transplantation following donation after brainstem death

Medtech innovation briefings:    Stable angina: management (CG126) - surveillance decision: NICE has decided after the new evidence that no update is necessary for this guideline. However, NICE will amend the guideline to include a footnote to the recommendations for third line drug treatments.

Sacubitril valsartan for treating symptomatic chronic heart failure with reduced ejection fraction
New and Updated Cochrane Systematic Reviews

Implantable loop recorder versus conventional diagnostic workup for unexplained recurrent syncope
Authors' conclusions: Our systematic review shows that there is no evidence that an ILR-based diagnostic strategy reduces long-term mortality as compared to a standard diagnostic assessment (very low quality evidence). No data were available for short-term all-cause mortality. Moderate quality evidence shows that an ILR-based diagnostic strategy increases the rate of aetiologic diagnosis as compared to a standard diagnostic pathway. No conclusive data were available on the other end-points analysed.

Further trials evaluating the effect of ILRs in the diagnostic strategy of people with recurrent unexplained syncope are warranted. Future research should focus on the assessment of the ability of ILRs to change clinically relevant outcomes, such as quality of life, syncope relapse and costs.

Exercise-based cardiac rehabilitation for adults after heart valve surgery
Authors' conclusions: Our findings suggest that exercise-based rehabilitation for adults after heart valve surgery, compared with no exercise, may improve exercise capacity. Due to a lack of evidence, we cannot evaluate the impact on other outcomes. Further high-quality randomised clinical trials are needed in order to assess the impact of exercise-based rehabilitation on patient-relevant outcomes, including mortality and quality of life.
Revascularization for acute coronary syndromes
Updated 2016 Apr 11 08:18:00 AM: invasive treatment strategy including early assessment by coronary angiography may reduce myocardial infarction and urgent revascularization in patients ≥ 80 years old hospitalized with non-ST-elevation myocardial infarction or unstable angina (Lancet 2016 Jan 12 early online) view update

Antiplatelet and anticoagulant drugs for elective percutaneous coronary intervention (PCI)
Updated 2016 Apr 11 06:54:00 AM: extended dual antiplatelet therapy with aspirin plus P2Y12 inhibitor may reduce risk of major adverse cardiovascular events, but may increase risk of major bleeding compared to aspirin alone in patients with prior myocardial infarction (Eur Heart J 2016 Jan 21) view update
Other Good Quality Systematic Reviews and Articles

Aortic-Valve Replacement

Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients  

Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention in Patients With Left Ventricular Systolic Dysfunction: A Meta-Analysis

Preoperative Prophylactic Intraaortic Balloon Pump Reduces the Incidence of Postoperative Acute Kidney Injury and Short-Term Death of High-Risk Patients Undergoing Coronary Artery Bypass Grafting: A Meta-Analysis of 17 Studies

Contemporary outcomes after surgical aortic valve replacement with bioprostheses and allografts: a systematic review and meta-analysis

Meta-Analysis of the Effectiveness and Safety of Transcatheter Aortic Valve Implantation Without Balloon Predilation

Impact of Antiphospholipid Syndrome and/or Systemic Lupus Erythematosus on the Long-term Adverse Cardiovascular Outcomes in Patients After Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis

Effectiveness of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With End-Stage Renal Disease

Efficacy and safety of routine thrombus aspiration in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: An updated systematic review and meta-analysis of randomized controlled trials

Comparison of the Postprocedural Quality of Life between Coronary Artery Bypass Graft Surgery and Percutaneous Coronary Intervention: A Systematic Review
Reports

National Congenital Heart Disease audit report 2012‐15
The Healthcare Quality Improvement Partnership has published the National Congenital Heart Disease Audit 2012-2015.  The report shows survival for children undergoing cardiac procedures for congenital heart disease has continued to improve in recent years. It also shows that antenatal detection rates continue to improve. 

National Audit of Percutaneous Coronary Interventions
HQIP has published the National Audit of Percutaneous Coronary Interventions Annual Public Report January 2014 - December 2014.  This latest audit shows an increase from 26.9% to 75.3% in the use of a safer method of PCI (angioplasty) between 2007 and 2014. 

Acute coronary syndrome guidance
The Scottish Intercollegiate Guidelines Network, Healthcare Improvement network has published Acute coronary syndrome guideline 148.  This guideline provides recommendations on the management of patients with acute coronary syndrome. It covers presentation, assessment and diagnosis, initial management, reperfusion therapy, risk stratification and non-invasive testing, invasive investigation and revascularisation, early pharmacological intervention and treatment of hypoxia and cardiogenic shock and includes a checklist of information for patients
NHS Behind the Headlines - media stories explained

Study argues ditching butter for veg oil won't prevent heart disease

Study suggests gene may turn 'good' cholesterol into 'bad'

Can HRT in early menopause cut heart disease risk?

New drug 'effective' for those with intolerable statin side effects

'Dying of heartache?' Heart problems linked to bereavement

Effects of vitamin D for heart failure far from 'stunning'

Fruit may be good for you, but don’t ditch the statins

Can happiness break your heart?
Our mailing address is: keith.nockels@uhl-tr.nhs.uk
 
Copyright © 2016 UHL Clinical Librarian Service, All rights reserved.
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