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CONTENTS
Head of the Biochemistry & Molecular Biophysics Department Named
Welcome to New Faculty
New Faculty Positions
Welcome Picnic
Core Facilities in the BMB Department
Welcome to New BMB Arrivals
Latest Publications
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Head of Biochemistry and Molecular Biophysics Named
John A. Cooper, MD, PhD, has been named head of the Department of Biochemistry and Molecular Biophysics at Washington University School of Medicine in St. Louis. More....
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Gregory R. Bowman - The Bowman lab combines simulation and experiment to understand the conformational changes proteins undergo and how these changes allow information to flow, both within single proteins and within networks of interacting proteins. Two major application areas are (1) understanding hidden allosteric sites and the opportunities they present for drug design and (2) understanding the molecular mechanisms of vision, especially the origins of inherited forms of blindness. To facilitate these applications, we also develop enhanced sampling algorithms for simulating long timescale dynamics of proteins and nucleic acids.
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Michael J. Greenberg - The Greenberg lab focuses on the generation and transduction of forces by molecular motors, with an emphasis on human disease. The lab uses an array of biochemical, biophysical and cell biological techniques to probe the function and regulation of these motors over a range of scales that extends from single molecules to tissues. Currently, the lab is studying the molecular basis of heart failure.
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The BMB department is searching for new faculty to fill multiple positions. We are open to candidates of all levels. If you know of anyone who might be interested in a position, please pass this information along. Details can be found at our website: http://biochem.wustl.edu/support/positions-available
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On August 20th, we held our Annual Joint Departmental and Graduate Program BBQ for the new graduate students starting this fall in the programs of Biochemistry and Computational & Molecular Biophysics. Everyone enjoyed food, drinks and games in Forest Park.
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Core Facilities in the BMB Department
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High Throughput Screening Facility
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The High-Throughput Screening Core (HTSC) has successfully completed its first year in operation in its remodeled space on the 2nd floor of Cancer Research Building. The HTSC is the combination of two former screening cores: the CGSC and the HTC, and represents a collaboration between the Siteman Cancer Center and the Department of Biochemistry and Molecular Biophysics.
The number of HTSC Users, who come from multiple departments across Washington University as well as Saint Louis University, has continued to grow in the past year. They have taken advantage of the various resources and services available at the Core, including small molecule and siRNA collections, automated high speed fluorescent and brightfield microscopes, and specialized instrumentation (multimode plate readers, liquid handling equipment) for plate-based assay implementation and high throughput screening.
The Core facilitates efforts towards identifying molecules or genes that modulate investigators’ biology of interest. Assay systems range from in vitro enzymatic or protein interaction assays to cell-, organoid-, and whole organism-based readouts. Some of the projects that the HTSC was involved with in the past year include:
- Effects of microbial metabolites on intestinal stem/progenitor cell proliferation
- Targeting the RelMtb enzyme to combat Mycobacterium tuberculosis infection
- Drug modulation of protein secretion in kidney cells
- Targeting malarial and human glucose transport with small molecule inhibitors
- Development of high throughput screening assays to identify inhibitors of viral nucleoprotein interactions
- Regulators of snail transcription factor stability
- Mechanisms of gastrointestinal adenocarcinoma tumorigenesis
- Determinants of aging and lifespan in worms
The Core also provides assay development expertise and grant writing support to investigators interested in applying high throughput screening and high content imaging approaches to their studies. To help support some of these research activities, eligible investigators can apply to the ICTS Just-in-time Core Usage funding program.
For a detailed description of the HTS Core’s resources and services, please visit the Core’s website (htsc.wustl.edu) or contact the Scientific Director, Maxene Ilagan (ilaganmg@wustl.edu).
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The Biochemistry & Molecular Biophysics NMR Facility consists of 3 NMR Spectrometers (500, 600, 700 MHz). Our 600 MHz instrument is fitted with a triple-resonance cryoprobe. The facility serves the needs of investigators studying biomolecular structure, macromolecular interactions and dynamics.
For more information please visit the NMR Facility website:
http://biochem.wustl.edu/bmbnmr/Facilities.html
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WUSM Structural Biology Core
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WUSM Structural Biology Core (X-ray Facility) is a state of the art macromolecular crystallography facility formed by eight faculty (Drs. Amarasinge, Brett, Ellenberger, Fremont, Hultgren, Li, Tolia, and Yuan) representing four different primary Departments (Pathology & Immunology, Biochemistry & Molecular Biophysics, Microbiology, and Cell Biology). Resources include three X-ray-generators (two Rigaku, one Xenocs), with four image plate detectors supported with near liquid nitrogen cold heads, two Mosquito robots, a Gryphon LCP device, and a Rigaku HT Minstrel and CrystalMation Gallery. The core facility also supports broad access to SBGRID crystallography software as well as dedicated synchrotron beam line access through membership in the MBC consortium at the Advanced Light Source in Berkeley, CA (Beamline 4.2.2). For training, or to schedule time to use the X-ray data collection systems, please contact Rick Stegeman by e-mail at stegemanr@biochem.wustl.edu or visit the Core's website at sbc.wustl.edu
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The BMB department is searching for new faculty to fill multiple positions. We are open to candidates of all levels. If you know of anyone who might be interested in a position, please pass this information along. Details can be found at our website: http://biochem.wustl.edu/support/positions-available
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BMB Department Welcomes...
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Nicholas Bodmer-Postdoctoral Research Assistant in Jim Harvranek's lab.
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Drew Braet-Research Technician in Michael Greenberg's lab.
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Lina Greenberg-Staff Scientist in Michael Greenberg's lab.
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Carrie Sibbald-Research Technician in Greg Bowman's lab.
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Program Students:
BCM
Patrick Judge
George Katumba
Justin MIller
Cameron Sargent
Lindsey Steinberg
CMBP
Drake Jensen
Edward Peneguy
Brittany Smith
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