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Colorectal Evidence Update

1st March 2017

Molecular testing strategies for Lynch syndrome in people with colorectal cancer
Cochrane Systematic Reviews

Second-line systemic therapy for metastatic colorectal cancer
Read Authors' Conclusions

Dietary fibre for the prevention of recurrent colorectal adenomas and carcinomas
Read Authors' Conclusions
Journal Clubs
Do journal clubs improve patient care and decision making?   
Do they help put evidence into practice?

If you attend a journal club, please fill in our 12 question survey at http://bit.ly/2j7VfHh.

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  • non-aspirin NSAIDS associated with decreased risk of advanced metachronous neoplasia compared to placebo or other treatments in patients who had prior resection of colorectal neoplasia (BMJ 2016 Dec 5)
  • comparison of 2 guidelines on screening for colorectal cancer (National Guideline Clearinghouse 2016 Dec 26) 
  • USMSTFCC guideline on colonoscopy surveillance after colorectal cancer resection (National Guideline Clearinghouse 2016 Oct 31) 
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Leicester Publications

A single institution's long-term follow-up of patients with pathological complete response in locally advanced rectal adenocarcinoma following neoadjuvant chemoradiotherapy.
Runau F, Collins A, Fenech GA, Ford E, Dimitriou N, Chaudhri S, Yeung JM.

Repeat hepatectomy is independently associated with favorable long-term outcome in patients with colorectal liver metastases.
Neal CP, Nana GR, Jones M, Cairns V, Ngu W, Isherwood J, Dennison AR, Garcea G.

Colorectal cancer cells use the negative feedback regulators of WNT signalling to activate epithelial-mesenchymal transition pathways.
Tulchinsky E.

Diagnostic accuracy of faecal biomarkers in detecting colorectal cancer and adenoma in symptomatic patients.
Widlak MM, Thomas CL, Thomas MG, Tomkins C, Smith S, O'Connell N, Wurie S, Burns L, Harmston C, Evans C, Nwokolo CU, Singh B, Arasaradnam RP.

Abdominal fat ratio - a novel parameter for predicting conversion in laparoscopic colorectal surgery
Scott SI, Farid S, Mann C, Jones R, Kang P, Evans J.

Can you offer help with statistics?
The Library would like to compile a list of people who can offer colleagues help with doing statistics.  Research or writing for publication may involve using statistics. Some people have access to help (for example, through a local University, from other members of the research team, or from the sponsor or organiser of the research), but some do not.
 
If you would like to join this list, and receive requests for help, please fill in this form at http://bit.ly/2jF227j  
 
The Library is compiling lists of books and other resources about statistics.   Watch our website for details.
Other Systematic Reviews

Decision-making in rectal and colorectal cancer: systematic review and qualitative analysis of surgeons' preferences.

The Role of Neoadjuvant and Adjuvant Systemic Chemotherapy with Cytoreductive Surgery and Heated Intraperitoneal Chemotherapy for Colorectal Peritoneal Metastases: A Systematic Review.

Predictive and prognostic biomarkers in colorectal cancer: A systematic review of recent advances and challenges.

Systematic review of the feasibility of laparoscopic reoperation for early postoperative complications following colorectal surgery.

Systematic Review of Pelvic Exenteration With En Bloc Sacrectomy for Recurrent Rectal Adenocarcinoma: R0 Resection Predicts Disease-free Survival.

Outcome and Salvage Surgery Following "Watch and Wait" for Rectal Cancer after Neoadjuvant Therapy: A Systematic Review.

Incidence, Risk Factors, and Trends of Motor Peripheral Nerve Injury After Colorectal Surgery: Analysis of the National Surgical Quality Improvement Program Database.

Intraperitoneal chemotherapy and cytoreductive surgery for peritoneal metastases coupled with curative treatment of colorectal liver metastases: an updated systematic review.

Folic Acid Supplementation May Reduce Colorectal Cancer Risk in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.

Molecular Biomarkers for the Evaluation of Colorectal Cancer: Guideline From the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and American Society of Clinical Oncology.

Reports 
NIHR Signal 
Enhanced patient education improves bowel preparation before colonoscopy.
Evidence review looking at seven trials, which all used different patient education interventions.

Bowel cancer audit 
The Healthcare Quality Improvement Partnership (HQIP) has published National Bowel Cancer Audit Annual Report 2016.  National Bowel Cancer Audit Patient Report 2016.  This report includes data on over 30,000 patients diagnosed with bowel cancer between 1 April 2014 and 31 March 2015.  HQIP has also published a National Bowel Cancer Audit Patient Report 2016.
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