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Gastroenterology Evidence Update

27th February 2017

New and Updated Cochrane Systematic Reviews

Probiotics for people with hepatic encephalopathy
Read Authors' Conclusions

Psychosocial interventions for recurrent abdominal pain in childhood
Read Authors' Conclusions
The Joanna Briggs Institute Systematic Reviews
 
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Constipation (Older People): Non-Pharmacological Interventions
Evidence Summary
PICO Question: What is best available evidence regarding the non-pharmacological management of constipation in the older person? 

Topic: Crohn disease in adultsUlcerative colitisFecal microbiota transplantation
Multidonor, intensive-dosing fecal microbiota transplant may increase remission at end of treatment in patients with active ulcerative colitis (Lancet 2017 Feb 14 early online)

Topic: Chronic pancreatitis
Expert evidence-based guideline on management of exocrine pancreatic insufficiency after pancreatic surgery (Ann Surg 2016 Dec)

Topic: Colonoscopy
Endocuff colonoscopy may not increase adenoma detection or reduce patient discomfort compared to conventional colonoscopy in adults (Gut 2015 Dec 16 early online)

Topic: Flexible sigmoidoscopy for colorectal cancer screening
Benefit of flexible sigmoidoscopy screening for reducing colorectal cancer incidence and mortality may vary by age, sex, and colon region (BMJ 2017 Jan 13)

Topic: Clostridium difficile infection
American Gastroenterologic Association (AGA) Institute expert review of management of C. difficile infection in patients with inflammatory bowel disease (Clin Gastroenterol Hepatol 2017 Feb)

Topic: Constipation in adults
Plecanatide (Trulance) FDA approved for use in adult patients with chronic idiopathic constipation (FDA Press Release 2017 Jan 19 )

Topic: Acute upper nonvariceal gastrointestinal bleeding
Glasgow Blatchford score with cutoff ≤ 1 may have best predictive performance compared to 4 other clinical risk scores for identifying patients presenting with evidence of upper gastrointestinal bleeding who can be safely managed as outpatients (BMJ 2017 Jan 4)

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Other Selected Systematic Reviews

Defining endoscopic response and remission in ulcerative colitis clinical trials: an international consensus.

Systematic review with meta-analysis: rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth.

Review article: dose optimisation of infliximab for acute severe ulcerative colitis.

Association Between Proton Pump Inhibitors and Microscopic Colitis.

Medication non-adherence in adult patients affected by inflammatory bowel disease: a critical review and update of the determining factors, consequences and possible interventions.

Advanced endoscopy imaging in inflammatory bowel diseases.

Efficacy of psychotropic drugs in functional dyspepsia: systematic review and meta-analysis.

Comparative Effectiveness of Mesalamine, Sulfasalazine, Corticosteroids, and Budesonide for the Induction of Remission in Crohn's Disease: A Bayesian Network Meta-analysis.

Bactericidal/permeability increasing protein gene polymorphism and inflammatory bowel diseases: meta-analysis of five case-control studies.

Update on hepatitis C treatment: systematic review of clinical trials.

Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis.

Association of gastro-oesophageal reflux and chronic rhinosinusitis: systematic review and meta-analysis.

Systematic review with meta-analysis: the impact of Clostridium difficile infection on the short and long-term risks of colectomy in inflammatory bowel disease.
UpToDate

What's new in gastroenterology and hepatology
Reports 

CCG Where to Look packs
NHS RightCare has updated CCG Commissioning for Value Where to Look packs.  The updates include expenditure data from 2015/16, an additional three pathways on a page for gastro-intestinal and an update of the complex patients analysis using 2015/6 data.  The updated packs also contain a new slide highlighting the potential overuse in bed days.

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