CTSI Weekly Update
University of Rochester Clinical and Translational Science Institute

6th Annual Medical Scientist Research Symposium
MSRS Keynote Talk: “Innate Allergy?”

Presented By:  Richard M. Locksley, MD, Professor of Medicine (Infectious Disease), UCSF; Marion & Herbert Sandler Distinguished Professorship in Asthma Research
 
Dr. Locksley's laboratory focuses on mechanisms by which the immune system becomes organized in stereotyped ways against discrete types of challenges. This involves the differentiation of naïve helper T cells to subsets that produce different kinds of cytokines, key effector molecules of the immune system. In turn, these different T cells subsets work with different kinds of innate cells, including neutrophils, eosinophils, macrophages, and others, to mediate immunity. Properly executed, such responses mediate protection against infectious organisms or repair of damaged tissues, but when dysregulated, these immune responses lead to disease, including asthma.  Sponsored by the Medical Scientist Training Program and the Dr. Thomas A. and Joyce E. Pearson Endowed Lectureship Fund.  Free and open to the entire UR community. 
NOTE: ALL students must register in advance if submitting an abstract at: urmcmsrs.wordpress.com
 
Date: Friday, April 7, 2017
Time: 3:00 – 4:30 pm
Location:  URMC - Class of ’62 Auditorium

Q & A with Former KL2 Scholar Wakenda Tyler: Balancing Orthopaedic Surgery and Rare Cancer Research


Wakenda Tyler, M.D., M.P.H., associate professor of Orthopaedics and 2010 recipient of a CTSI KL2 Career Development Award, discusses how the KL2 award helped her to carve out the time to research how renal cell carcinoma, a rare type of kidney cancer, spreads to bone.  “Since early in my medical school training, I knew I wanted to be a surgeon who treats patients with cancer. My areas of special interest include musculoskeletal oncology, sarcoma, and metastatic bone cancer...The KL2 project investigated how renal cell carcinoma, a rare type of kidney cancer, spreads to bone. There's something about bone that makes renal cell carcinoma unresponsive to treatments, even as this cancer responds to chemotherapy in other areas of the body.  Read more on the CTSI Stories Blog.

 

Reflecting Our Community: Tackling Racial and Ethnic Disparities in Health Care and Research

University of Rochester Medical Center, Office for Inclusion and Culture Development, and the Clinical and Translational Science Institute invite you to attend a one-day conference that will provide training and insights for challenging racial and ethnic disparities in health care and research.
Unconscious biases and cultural misunderstandings, as well as uninformed assumptions and oversights, can lead to disparities in health care for women, underrepresented groups, immigrants, LGBTQ individuals and others. This conference will enable clinicians to give better care to their patients and help researchers engage more diverse study populations.  For the Agenda and Registration: click here

Date: Monday, April 24, 2017
Time: 7:30 am – 4:00 pm
Location: URMC - Flaum Atrium




 

Sources and Effects of Transcriptomic Heterogeneity

Presented By: Matthew N. McCall, PhD, Assistant Professor of Biostatistics, Assistant Professor of Biomedical Genetics
 
The Center for Biomedical Informatics Seminar Series continues with a talk by Matthew N. McCall, PhD, on Tuesday, March 28th. Measurement of transcriptomic expression in healthy and diseased tissue samples is integral to the study of cellular processes underlying the diseased phenotype. The continued development and application of transcriptomic biomarkers is critical for the success of precision medicine. Currently, a major challenge to translational biomedical research is the heterogeneity that exists between similar individuals, within an individual's tissue, and within a single tissue sample. These manifest as unexplained variation between samples presumed to be highly similar. In this talk, the proposal of statistical framework to identify, quantify, and adjust for sources of transcriptomic heterogeneity will be discussed.  Lunch will be provided.
 
Date: Tuesday, March 28, 2017
Time: 12:00 – 1:00 pm
Location:  URMC - K-307 Auditorium (3-6408)

 

New PhRMA Foundation $1 Million Value Assessment Initiative – Deadlines Approaching

A number of initiatives aiming to drive value in health care have emerged in recent years, but few offer transformative solutions that reflect patient preferences and real-world clinical practice. In addition, many issues in methodology and patient engagement remain unresolved. The PhRMA Foundation Value Assessment Initiative, a three-part award program, aims to address these challenges. The three separate programs within this initiative will be awarding up to one million dollars.  They are: Challenge, Research, and Center of Excellence.  For details on this program, please go to the PhRMA Foundation website.


The deadlines for the letters of intent are:
Challenge Awards – March 27th
Research Awards – May 1st
Planning Awards/Center of Excellence – May 1st




 

In Other News....

Unconference: Building Bridges for Healthy Weight Initiatives

The “unconference” will be the beginning of a long-term process to develop new collaborations for research projects and programs. We would like to have people with truly different perspectives. The quote below is from a conference website about teams of the future developed by the New York Times. It summarizes the spirit of what we want to achieve: “…the best teams might not be the most obvious ones when it comes to shooting for the moon.”  The conference is Saturday, March 25, 8:30am - 3:45pm Saunders Research Building Atrium, 265 Crittenden Blvd, Rochester, NY 14642 For more information, click here.

 

Trust Your Gut: The Control of Growth Patterning and Drug Response of the Intestinal Epithelium

Presented By: Curtis A. Thorne, PhD, Postdoctoral Fellow, Systems Biology/Pharmacology, University of Texas Southwestern Medical Center, Faculty Candidate, Cancer Biology, Wilmot Cancer Institute
Please note revised time.
Date: Monday, March 20, 2017
Time: 1:45 – 2:45 pm
Location: URMC - K-207 (Room #2-6408)

               
 

Monday, March 20th
What Does it Mean to Be Dead, and Why Should it Matter?

Trust Your Gut: The Control of Growth Patterning and Drug Response of the Intestinal Epithelium

Tuesday, March 21st  
Nominations for 2017 Academic Mentoring Awards

Medical Grand Rounds: Medical Futility

Wednesday, March 22nd   
Without Compassion, There is No Health Care

Genomic Mechanisms of Gene Regulation and Chromatin Organization

Thursday, March 23rd  
Innovations in Quality through Collaborative Practice - Team Based Care Summit

Environmental Impact on Skeletal Muscle Maintenance and Regeneration

New Brilliant Norms: Transforming the Learning Context to Enhance Diversity, Inclusion, and Excellence

Identifying Critical Pregnancy Windows of Susceptibility to Ambient Air Pollution Exposure

Friday, March 24th  
Transforming the Care of Childhood-Onset Chronic Health Conditions: An Interdisciplinary Approach

62nd Annual Rochester Ophthalmology Conference

Causal Inference

Adaptation to Motion in Cortically Blind Patients

Medical Management Experience

Unconference: Building Bridges for Healthy Weight Initiatives
 

Funding Opportunities

Monday, March 20th 
Deadline for Submissions: University Research Awards

Deadline for Submissions: PumpPrimer II Applications

Deadline for Submissions: Furth Fund Nominations

Tuesday, March 21st
Nominations for 2017 Academic Mentoring Awards

Thursday, March 23rd
Deadline for Submissions: Innovations in Quality through Collaborative Practice - Team Based Care Summit

Friday, March 24th
Medical Management Experience

Monday, March 27th
New PhRMA Foundation $1 Million Value Assessment Initiative

Monday, April 10th
Deadline for Submissions: Schmitt Program in Integrative Neuroscience Pilot and Feasibility Awards

Thursday, April 13th
Deadline for Submissions: Research Visits to Chinese University of Hong Kong

Thursday, April 20th
Preparing Single IRB Grant Submissions Utilizing the RSRB as the Reviewing IRB
Deadline for Submissions: Falling Walls Lab Rochester

Monday, May 1st                                      
New PhRMA Foundation $1 Million Value Assessment Initiative

Monday, May 22nd
Collaborative Innovation Research Program

Thursday, September 7th
Grant Writers Coaching Group for NIH Awards
 
                         

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