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Respiratory Evidence Update
27th March 2017
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Topic: Silicosis
- Review of occupational lung disease (Lancet Respir Med 2017 Jan 6 early online)
- Review of silicosis (Front Immunol 2016 Mar 11)
Topic: Obesity hypoventilation syndrome03/06/2017 08:00:00 AM (ET)
- Nocturnal CPAP and BPAP may have similar efficacy in patients with severe hypoventilation of obesity (Thorax 2016 Nov 15 early online)
- Modified STOP-Bang Questionnaire maybe useful as initial screen for OHS in obese patients (Sleep Breath 2016 May)
- Oxygen supplementation during noninvasive ventilation does not appear to improve hypercapnia, sleepiness, quality of life, or pulmonary function in patients with OHS (J Clin Sleep Med 2016 Oct 15)
Topic: Asthma in adults and adolescents
- pulmonary function testing to reevaluate patients with asthma diagnosis within 5 years does not confirm diagnosis in about 33% (JAMA 2017 Jan 17)
- Addition of inhaled tiotropium to inhaled corticosteroids plus controller therapy might improve lung function in adolescents with severe asthma taking corticosteroid plus controller therapy (Eur Respir J 2017 Jan)
- Addition of aerobic exercise plus resistance muscle training to weight loss program may improve asthma in obese patients with asthma (Am J Respir Crit Care Med 2017 Jan 1)
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Leicester Publications
Emerging Therapies in Severe Eosinophilic Asthma.
Pang PH, Brightling CE.
Accurately measuring and modeling Th2 and Th17 endotypes in severe asthma.
Hart KM, Choy DF, Bradding P, Wynn TA, Arron JR.
A CEACAM6-High Airway Neutrophil Phenotype and CEACAM6-High Epithelial Cells Are Features of Severe Asthma.
Shikotra A, Choy DF, Siddiqui S, Arthur G, Nagarkar DR, Jia G, Wright AK, Ohri CM, Doran E, Butler CA, Hargadon B, Abbas AR, Jackman J, Wu LC, Heaney LG, Arron JR, Bradding P.
Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa
Waters EM, Neill DR, Kaman B, Sahota JS, Clokie MR, Winstanley C, Kadioglu A.
HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4.
Di Candia L, Gomez E, Venereau E, Chachi L, Kaur D, Bianchi ME, Challiss RA, Brightling CE, Saunders RM.
The relationship between the Leicester cough questionnaire, eosinophilic airway inflammation and asthma patient related outcomes in severe adult asthma.
Natarajan S, Free RC, Bradding P, McGarvey L, Siddiqui S.
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A Million Decisions: evidence-based healthcare
Health Education England and the Chartered Institute of Library and Information Professionals have launched a joint campaign for decisions in the healthcare sector to be fully evidence-based. Every day more than a million decisions are made that have a profound and lasting impact on people's lives and which influence the quality of healthcare and the cost of services.
The #milliondecisions campaign campaign calls for everyone involved in policy making and care delivery to use the skills of librarians and knowledge specialists in meeting their obligations under the Health and Social Care Act 2012. |
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Journal Clubs
Do journal clubs improve patient care and decision making?
Do they help put evidence into practice?
If you attend a journal club, please fill in our 12 question survey at http://bit.ly/2j7VfHh.
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Reports
Economic burden of lung disease
The British Lung Foundation has published Estimating the economic burden of respiratory illness in the UK. This report provides estimates of the total costs to the UK of respiratory disease in 2014. It shows lung disease costs the UK over £11 billion each year, in costs to the NHS and in lost productivity. The findings suggest that respiratory illness continues to represent a substantial burden to individuals, wider society and the healthcare system, and that research funding allocation for respiratory illness does not currently reflect this.
Inhaler standards and competency
The UK Inhaler Group (UKIG) has published Inhaler standards and competency document. This guidance set out how healthcare professionals can work with patients to optimise their technique and maximise the benefit of their medication.
National Paediatric Asthma Audit
The British Thoracic Society has published the BTS National Paediatric Asthma Audit. This audit examined the demographic profile, severity at presentation, processes of care and outcomes of children over 1 year of age admitted to hospital in the UK with an acute attack of wheezing/asthma during the month of November 2015.
Additional link: RCPCH press release
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