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Breast Cancer Evidence Update

28th March 2017

Familial breast cancer: classification, care and managing breast cancer and related risks in people with a family history of breast cancer

Early and locally advanced breast cancer: diagnosis and treatment
Online support groups for women with breast cancer
Read Authors' Conclusions

Interventions for raising breast cancer awareness in women
Read Authors' Conclusions

Topic: Chemotherapy for early and locally advanced breast cancer

  • In women with locally hormone receptor-positive breast cancer, omission of chemotherapy in women at low risk of recurrence (21-gene Recurrence Score ≤ 11) may not reduce 3-year disease-free survival (J Clin Oncol 2016 Jul 10)
  • Scalp cooling may prevent substantial hair loss in women with stage I or II breast cancer having chemotherapy (JAMA 2017 Feb 14)
  • Delayed initiation of adjuvant chemotherapy associated with reduced overall survival in women with breast cancer (Breast Cancer Res Treat 2016 Nov)


Topic: Breast cancer screening
Educational interventions for increasing breast cancer awareness may increase awareness of breast cancer symptoms, knowledge of age-related risk of breast cancer, and breast-checking behaviors (Cochrane Database Syst Rev 2017 Feb 10)

Other Selected Systematic Reviews

Dietary fat and breast cancer mortality: A systematic review and meta-analysis.

Mediterranean diet adherence and risk of postmenopausal breast cancer: results of a cohort study and meta-analysis.

Could yoga practice improve treatment-related side effects and quality of life for women with breastcancer? A systematic review and meta-analysis.

Systematic review of early and long-term outcome of liver resection for metastatic breast cancer: Is there a survival benefit?

The impact of exercise during adjuvant radiotherapy for breast cancer on fatigue and quality of life: A systematic review and meta-analysis.

pCR rates in patients with bilateral breast cancer after neoadjuvant anthracycline-taxane based-chemotherapy - A retrospective pooled analysis of individual patients data of four German neoadjuvant trials.

Hypofractionated whole breast radiotherapy in breast conservation for early-stage breast cancer: a systematic review and meta-analysis of randomized trials.

Long-term cardiovascular mortality after radiotherapy for breast cancer: A systematic review and meta-analysis.

 
Association between comorbidity and participation in breast and cervical cancer screening: A systematic review and meta-analysis.

Does the Time of Radiotherapy Affect Treatment Outcomes? A Review of the Literature.

Imaging performance in guiding response to neoadjuvant therapy according to breast cancer subtypes: A systematic literature review.

Mixed method systematic review: the relationship between breast cancer risk perception and health-protective behaviour in women with family history of breast cancer.

Estimate of false-positive breast cancer diagnoses from accuracy studies: a systematic review.

Marital adjustment in the context of female breast cancer: A systematic review.

Circulating tumor cell status monitors the treatment responses in breast cancer patients: a meta-analysis.

 
Leicester Publications

Prescribing tamoxifen in primary care for the prevention of breast cancer: a national online survey of GPs' attitudes.
Smith SG, Foy R, McGowan JA, Kobayashi LC, DeCensi A, Brown K, Side L, Cuzick J.

What influences healthcare professionals' treatment preferences for older women with operable breast cancer? An application of the discrete choice experiment.
Morgan JL, Walters SJ, Collins K, Robinson TG, Cheung KL, Audisio R, Reed MW, Wyld L.

Assessment of lead-time bias in estimates of relative survival for breast cancer.
Andersson TM, Rutherford MJ, Humphreys K.

Next Generation Sequencing of Circulating Cell-Free DNA for Evaluating Mutations and Gene Amplification in Metastatic Breast Cancer.
Page K, Guttery DS, Fernandez-Garcia D, Hills A, Hastings RK, Luo J, Goddard K, Shahin V, Woodley-Barker L, Rosales BM, Coombes RC, Stebbing J, Shaw JA.

TAp73 upregulates IL-1β in cancer cells: Potential biomarker in lung and breast cancer?
Vikhreva P, Petrova V, Gokbulut T, Pestlikis I, Mancini M, Di Daniele N, Knight RA, Melino G, Amelio 

100,000 Genomes project

This NHS project is an excellent opportunity for patients with rare conditions (including some congenital heart conditions), and certain cancers, and their families, to obtain a genetic diagnosis by genomic sequencing. It aims to sequence 100,000 genomes from NHS patients by 2018. More information here.  

UHL project members have produced “Eligibility Wheels” as a simple guide to help clinicians identify potential participants to join the 100,000 Genomes Project.   The wheels bring together conditions that would be seen by a physician in a clinic setting. They can be displayed in clinical areas where most useful, such as on consultation room noticeboards or in toggled booklets.  You can download the Eligibility Wheels from the following link: https://www.genomicseducation.hee.nhs.uk/taught-courses/eligibility-wheels-library/ .  

If you have any further enquiries, please contact the Leicester recruitment team via email: genomesproject@uhl-tr.nhs.uk  or by telephone on: 0116 258 6968.  

To access full text you may have to log in to your NHS Athens account (click here to register for free). If full text is not available then please email us to request a copy.
Reports

Breast Screening Programme England - 2015-16 Statistics

GP attitudes to cancer preventing drugs
Cancer Research UK has published Understanding GP attitudes to cancer preventing drugs.  This report presents the results of a survey of GPs about their use of offering tamoxifen and aspirin to lower the risk of, or prevent, certain cancers.  It found nearly half of GPs were unaware of the benefits of tamoxifen to prevent breast cancer.  The report concludes more needs to be done to ensure GPs are given the support they need.  Additional link: Cancer Research UK press release

NIHR Signals summary Delaying chemotherapy after breast cancer surgery may reduce survival chances
Can you offer help with statistics?
The Library would like to compile a list of people who can offer colleagues help with doing statistics.  Research or writing for publication may involve using statistics. Some people have access to help (for example, through a local University, from other members of the research team, or from the sponsor or organiser of the research), but some do not.
 
If you would like to join this list, and receive requests for help, please fill in this form at http://bit.ly/2jF227j  
 
The Library is compiling lists of books and other resources about statistics.   Watch our website for details.
NHS Behind the Headlines - media stories explained

GPs 'failing to prescribe tamoxifen to prevent breast cancer'

New breast cancer drugs could help more than previously thought

Mediterranean diet linked to lower risk of one type of breast cancer

Exercise 'most proven method' to prevent return of breast cancer

Is bad luck the leading cause of cancer?

The pill provides 'lifelong protection against some cancers'
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