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Stroke Evidence Update

13th September 2016

Do you have any research needs? 
Please contact your Stroke Librarian, Pip Divall on 0116 250 2309 or  Pip.Divall@uhl-tr.nhs.uk
New and Updated Cochrane Systematic Reviews

Immediate versus delayed treatment for recently symptomatic carotid artery stenosis
Authors' conclusions:There is currently no high-quality evidence available to support either very early or delayed cerebral revascularization after a recent ischemic stroke. Hence, further randomized trials to identify which patients should undergo very urgent revascularization are needed. Future studies should stratify participants by age group, sex, grade of ischemia, and degree of stenosis. Currently, there is one ongoing RCT that is examining the timing of cerebral revascularization.

Cognitive rehabilitation for memory deficits after stroke
Authors' conclusions: Participants who received cognitive rehabilitation for memory problems following a stroke reported benefits from the intervention on subjective measures of memory in the short term (i.e. the first assessment point after the intervention, which was a minimum of four weeks). This effect was not, however, observed in the longer term (i.e. the second assessment point after the intervention, which was a minimum of three months). There was, therefore, limited evidence to support or refute the effectiveness of memory rehabilitation. The evidence was limited due to the poor quality of reporting in many studies, lack of consistency in the choice of outcome measures, and small sample sizes. There is a need for more robust, well-designed, adequately powered, and better-reported trials of memory rehabilitation using common standardised outcome measures.

Acupuncture for stroke rehabilitation
Authors conclusions: From the available evidence, acupuncture may have beneficial effects on improving dependency, global neurological deficiency, and some specific neurological impairments for people with stroke in the convalescent stage, with no obvious serious adverse events. However, most included trials were of inadequate quality and size. There is, therefore, inadequate evidence to draw any conclusions about its routine use. Rigorously designed, randomised, multi-centre, large sample trials of acupuncture for stroke are needed to further assess its effects.

Cochrane Clinical Answers
 

In people with symptomatic carotid artery stenosis, how do endovascular treatment and endarterectomy compare?

Is there randomized controlled trial evidence to support the use of information provision in people with stroke and their caregivers?

How do cilostazol and aspirin compare for the prevention of vascular events after stroke of arterial origin?

Antiplatelet agents for secondary prevention of stroke
Aspirin appears to reduce risk of ischemic stroke in first 12 weeks, and especially within first 6 weeks, after transient ischemic attack or ischemic stroke (Lancet 2016 Jul 23)
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Primary Research and Evidence Syntheses

Efficacy and Safety of Novel Oral Anticoagulants in Patients With Atrial Fibrillation and Heart Failure: A Meta-Analysis.

Standard versus low dose non-Vitamin k antagonist oral anticoagulants in Asian patients with atrial fibrillation: A meta-analysis of contemporary randomized controlled trials.

Relation of Body Mass Index With Adverse Outcomes Among Patients With Atrial Fibrillation: A Meta-Analysis and Systematic Review.

Characteristics and adaptive strategies linked with falls in stroke survivors from analysis of laboratory-induced falls.

Carotid endarterectomy versus carotid angioplasty for stroke prevention: a systematic review and meta-analysis.

Thyroid Function within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis.

Effects of Robot-Assisted Therapy for the Upper Limb After Stroke: A Systematic Review and Meta-analysis.

Association of BMI with total mortality and recurrent stroke among stroke patients: A meta-analysis of cohort studies.

Efficacy and safety of oral direct factor Xa inhibitors versus warfarin in patients with atrial fibrillation: a meta-analysis of randomized controlled trials.

Recurrent stroke risk and cerebral microbleed burden in ischemic stroke and TIA: A meta-analysis.

What is current practice for upper limb rehabilitation in the acute hospital setting following stroke? A systematic review.

Novel oral anticoagulants for the secondary prevention of cerebral ischemia: a network meta-analysis.

Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events: Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48).
 

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Leicester Publications 

Exploratory Network Meta Regression Analysis of Stroke Prevention in Atrial Fibrillation Fails to Identify Any Interactions with Treatment Effect.

External Validation of Randomized Trial Outcomes Following Carotid Interventions in the Modern Era.

Urgent Carotid Endarterectomy Does Not Increase Risk and Will Prevent More Strokes

The Leicester cerebral haemodynamics database: normative values and the influence of age and sex 
There were no new guidelines this issue
NHS Behind the Headlines - media stories explained

Statins are 'safe, effective and should be used more widely'

Calcium supplements linked to post-stroke dementia in women

UK heart disease and stroke death rates now lower than cancer
Reports

The Kings Fund has published What if everyone over 55 was offered a pill to prevent heart attacks and strokes? This is another essay from the King’s Fund ‘What If hypothetical scenarios series’ exploring the future of health and healthcare.  In this latest essay the author argues that offering a polypill to everyone over 55 could dramatically reduce the number of deaths from stroke and cardiovascular disease.
Table of Contents

Cerebrovascular Diseases
Experimental & Translational Stroke Medicine
International Journal of Stroke
Journal of Stroke & Cerebrovascular Diseases
Stroke
Stroke Research and Treatment
Our mailing address is: pip.divall@uhl-tr.nhs.uk
 
Copyright © 2016 UHL Clinical Librarian Service, All rights reserved.
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