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Please do contact your Pain Librarian, Pip Divall, for any information and research assistance 0116 250 2309 or Pip.Divall@uhl-tr.nhs.uk
Pregabalin for pain in fibromyalgia in adults Authors' conclusions: Pregabalin 300 to 600 mg produces a major reduction in pain intensity over 12 to 26 weeks with tolerable adverse events for a small proportion of people (about 10% more than placebo) with moderate or severe pain due to fibromyalgia. The degree of pain relief is known to be accompanied by improvements in other symptoms, quality of life, and function. These results are similar to other effective medicines in fibromyalgia (milnacipran, duloxetine).
Single fixed-dose oral dexketoprofen plus tramadol for acute postoperative pain in adults Authors' conclusions: A single oral dose of dexketoprofen 25 mg plus tramadol 75 mg provided good levels of pain relief with long duration of action to more people than placebo or the same dose of dexketoprofen or tramadol alone. The magnitude of the effect was similar to other good analgesics. Adverse event rates were low. There is modest uncertainty about the precision of the point estimate for efficacy, but the NNT of 3 is consistent with other analgesics considered effective and commonly used.
Liposomal bupivacaine peripheral nerve block for the management of postoperative pain Authors' conclusions: A lack of evidence has prevented an assessment of the efficacy of liposomal bupivacaine administered as a peripheral nerve block. At present there is a lack of data to support or refute the use of liposomal bupivacaine administered as a peripheral nerve block for the management of postoperative pain. Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
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Naloxone coprescription associated with fewer opioid-related emergency department visits in patients receiving long-term opioid medications for pain (Ann Intern Med 2016 Aug 16)
