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Research Evidence Update
October 2016
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Grants/ Funding/ Opportunities
NIHR Projects and Programmes
Confused about which funding stream you should apply to? Then join us on 15 November in Leicester for a closer look at:
- Research for Patient Benefit (RfPB)
- Efficacy and Mechanism Evaluation (EME)
- Health Technology Assessment (HTA)
This event will offer three 30 minute presentations covering the aims of the programmes, the sorts of studies that the panels would like to see and essential application tips.
Time: 10am-12pm, 15 November 2016, followed by a networking lunch
Venue: College Court, Knighton Road, Leicester, LE2 3UF, Sat Nav - LE2 3TQ
Alert: don't miss the networking lunch! It's your chance to ask your questions directly to the presenters and regional panel members.
To register a place at this event please fill out our booking form
The Health Foundation funding call to improve Evidence into Practice
This new programme of grants from the Health Foundation of up to £50,000 will fund the development of tools and resources, based on completed research studies, to support the implementation of findings in practice.
Successful proposals will be those that appear most creative, innovative and likely to have impact. Evidence into Practice is designed to help research teams bridge the gap from academic research findings, to actionable information for people practising in the field.
Closing date for applications: Wednesday 16 November 2016.
Further information: www.health.org.uk/programmes/evidence-practice
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If you have a colleague who would like to be added to the Research Evidence Update circulation list, please contact the Clinical Librarian Service.
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Funding Opportunities
Drug development project - Cancer Research UK, GB
This supports the development of new cancer treatments from preclinical development through to early phase patient trials. Projects are supported for three to eight years. Funding covers the development of the agent.
Closing date: 21 Nov 16
MORE>>>
Methodology research programme - Medical Research Council
The Medical Research Council and the National Institute for Health Research invite proposals for their methodology research programme. This supports research on methods development to underpin the biomedical and health sciences as well as methods in research for developing methods and their implementation in research standards.
Closing date: 16 Nov 16
MORE>>>
NIHR Programme development - grants for applied research
Recurring opportunity
*** The National Institute for Health Research will shortly be inviting proposals for its programme development grants for applied research Competition 17
Closing date: 17 Nov 16
MORE>>>
Project grants - Action Medical Research for Children
Action Medical Research for Children invites outline proposals for its project grants. These support biomedical basic and clinical research related to preventing and treating disease and disability in children, with child health including problems affecting pregnancy, childbirth, babies, children and young people. In addition, grants are provided for research and development of equipment and techniques to improve diagnosis, therapy and assistive technology, including orthoses, prostheses and aids to daily living. Applications in the field of medical engineering are encouraged.
Closing date: 22 Nov 16
MORE>>>
NIHR Public health research programme – commissioned calls for proposals: 16/39, 16/40, 16/41, 16/50
The National Institute for Health Research invites proposals for its commissioned research calls under the public health research programme. Proposals should address the effectiveness of interventions, particularly on population level, for one of the following subjects:
•maintaining or increasing physical activity for people in mid-life;
•preventing road injuries and promoting active travel;
•reducing sedentary behaviour such as sitting, lying down and watching television;
•promoting the benefits of or reducing harm from exposure to sunlight.
Closing date: 05 Dec 16
MORE>>>
Efficacy and Mechanism Evaluation Programme - Commissioned call
Closing date: 01 November 2016 Publish date: 12 July 2016
The Efficacy and Mechanism Evaluation Programme is accepting applications to their commissioned workstream for the following topics:
16/71 - Difficult to Treat Severe Asthma
16/70 - Non-Rheumatoid Arthritides
16/67 - Mechanisms of action of health interventions
Closing date: 1 November 2016.
MORE>>>
Efficacy and Mechanism Evaluation Programme - Researcher-led call
The Efficacy and Mechanism Evaluation Programme is accepting applications to its researcher-led work stream as follows:
16/68 - EME Researcher Led
Closing date: 1 November 2016
MORE>>>
NIHR Public Health Research Programme
The Public Health Research (PHR) Programme funds research that evaluates non-NHS interventions intended to improve the health of the public, and reduce inequalities in health. The scope of the programme is multi-disciplinary and broad, covering a range of public health interventions.
16/39 - Mid-life and physical exercise
16/40 - Preventing road injuries
16/41 - Sedentary behaviour
16/50 - Sun exposure
Closing date: 5th December, 2016
MORE>>>
Department of Health Policy Research Programme call
The Department of Health’s (DH) Policy Research Programme (PRP) is a national research funding programme that commissions high quality, research-based evidence relevant to the full policy remit of the DH.
DH PRP invites an application in the following area:
- Second Joint Call for the European Research Area Network on Illicit Drugs: Society and Responses to Drug Use
- The European Research Area Network on Illicit Drugs (ERANID) aims to improve cooperation in drug research in order to make well-founded, evidence-based policy decisions.
The Department of Health is part of their second joint call which will fund multidisciplinary transnational research in ‘Society and responses to drug use‘. The call encourages research that will provide a better understanding of society’s responses to drug use, building on and complementing the focus of the first joint call on understanding drug use pathways.
Other participating countries in this call are Belgium, France, Italy, Portugal, Scotland and The Netherlands. Only transnational projects of three or more countries will be funded.
A total of £250,000 to fund one or two projects is available.
Closing date: Tuesday 18 October 2016
MORE>>>
Health Technology Assessment Programme - Commissioned call
The Health Technology Assessment Programme is accepting applications on the following commissioning briefs, in the area of primary research:
- 16/89 Interventions for small bowel Crohn's disease
- 16/91 Take home naloxone for opiate overdose
- 16/92 The role of prophylactic antibiotics for botulinum toxin A injections for overactive bladder
- 16/93 Alpha-2 agonists for sedation in critical care
- 16/94 Gastric residual volume measurement in mechanically ventilated infants and children
- 16/95 Management of sexual dysfunction associated with antipsychotic drug therapy
- 16/96 Standardised diagnostic assessment tool as an adjunct to clinical practice in child and adolescent mental health services
- 16/97 Antipsychotics for anorexia nervosa
- 16/98 Down-titration of alendronate dosage
- 16/99 Primary prevention of variceal bleeding in patients with liver cirrhosis
- 16/100 Stem cell transplant in adults with severe sickle cell disease
- 16/101 De-escalation techniques and the use of restrictive interventions in adult mental health units
- 16/102 Understanding the impact of noisy breathing on carer distress and the use of antimuscarinic drugs at the end of life
Closing date : 7 February 2017.
MORE>>>
NIHR Research for Patient Benefit (RfPB) Programme Competition 31
RfPB competition 31 was launched recently in the same two-stage format as competition 28, 29 and 30.
The RfPB Programme funds NHS research. The projects funded are for regionally derived applied research in health services and social care. Applicants need to demonstrate the regional benefits of the proposed research although studies with national benefit will also be considered.
RfPB does not specify topics for research and encourages proposals for projects covering a wide range of health service issues and challenges. The programme funds a broad range of topics and research methodologies that increase the effectiveness of NHS services, provide value for money and benefit patients. The programme also supports relevant feasibility studies to help reach the next step of a definitive trial.
A Word template of the application form is available on the RfPB website and can be found here: http://www.nihr.ac.uk/funding/RfPB_guidance.htm
Closing date: 23 Nov 2016
MORE>>>
NIHR Public health research programme – researcher-led call for proposals: 16/105, 16/106
This supports research that evaluates public health interventions outside the NHS, specifically to provide new knowledge on the benefits, costs, acceptability and wider impacts of these interventions intended to improve the health of the public and reduce inequalities in health. There is no fixed limit on funding or the duration of the project.
16/105 Researcher-led, standard outline
16/106 - Researcher-led, evidence synthesis full
Maximum award: Not known
Closing date: 21 Nov 16
MORE>>>
NIHR Health technology assessment programme: researcher-led workstream
This supports research that is immediately useful to patients, clinical practice, and policy and decision makers, assessing the effectiveness of technologies within the NHS.
Maximum award: Not known
Closing date: 30 Nov 16 (recurring)
MORE>>>
Stratified medicine initiative – disease-focused partnerships to stratify for patient benefit
Department of Health including NIHR, GB
This supports consortia to address areas of medical research where there is a strong case for scientific advancement and major unmet clinical need. The total budget is £15 million over five years.
Maximum award: Not known
Closing date: 01 Dec 16
MORE>>>
Funding competition: antimicrobial resistance
14 September, 2016
Up to £4 million capital investment is available to enable research into antimicrobial resistance and advance the development of new products.
You must register before noon on 27 October 2016.
NORD Announces Research Grants Opportunities
Funding is available for the study of the following rare diseases:
These grants are made possible by donations to NORD. In some cases, the grants are co-sponsored by NORD and disease-specific patient organizations. NORD encourages all U.S. and international researchers interested in studying these diseases to consider applying. Submissions should be sent to: research@rarediseases.org
NIHR CLAHRC East Midlands: PhD/MD Travel/Research Prize Application
The latest call for applications for the NIHR CLAHRC East Midlands PhD/MD Travel and Research bursary prize will open on 1st October 2016.
We have up to six prizes to award PhD/MD students studying in the East Midlands. THis prize will cover the
costs incurred (or due to be incurred) between 1st October 2016 – 31st March 2017. If you have any questions about the prize or the application process, please get in touch with Emma Rowley@Emma.Rowley@nottingham.ac.uk”
Please see link for more details
http://www.clahrc-em.nihr.ac.uk/clahrc-em-nihr/news/phd-and-md-travel-research-prize-application.aspx
Deadline is 23.59pm on 15th December 2016.
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Training / Events
Upcoming Events
25th October @Northampton
RDS EM 'Filling in the application form' fellowship workshop
16th November @ London
Dementia: Quality of Care 2016 Conference
For more details about events please see our website:
http://www.rds-eastmidlands.nihr.ac.uk/events.html
NCRI Cancer Conference
The UK’s largest cancer research meeting will take place on 6-9 November 2016 at BT Convention Centre, Liverpool, UK. Please see link below for further details:
http://conference.ncri.org.uk/
The King’s Fund - Integrated Care Summit Event
A summit based on the Kings Fund report “Place based systems of care”
Please see link below for further details:
http://www.kingsfund.org.uk/events/annual-integrated-care-summit-2016.
The King’s Fund Annual Conference is on 9th November.
Please see link below for further details:
http://www.kingsfund.org.uk/events/kings-fund-annual-conference-2016
Qualitative Research Methods
31 October – 4 November 2016
19 – 23 June 2017 @ Rewley House, 1 Wellington Square, Oxford, UK
Register HERE to attend.
Exploring qualitative research
This module will provide an overview of the principles and practice of qualitative research.
Full details and information on how to apply can be found on the course webpage -
https://www.conted.ox.ac.uk/courses/qualitative-research-methods
A pathologist’s guide to research and clinical trials
Conference
9th December 2016 @ London
Organised by the Royal College of Pathologists with the National Cancer Research Initiative & CM-path (Cellular molecular pathology initiative).
More details and booking at
https://www.rcpath.org/event/clinical-trials-for-pathologists.html
Mixed Methods in Health Research
24–28 April 2017 @ Oxford, UK
This module will introduce students to the nature and design of mixed methods research. This module assumes students will have some experience in either qualitative or quantitative methodologies.
Full details and information on how to apply can be found on the course webpage - http://www.conted.ox.ac.uk/mmhr
Webinar: Getting your finances right - from application to the end of your project webinar
Date: 18 October, 2pm
Booking: Register for the webinar
This webinar will be an introductory webinar on the finance aspects NIHR trainees should consider from application and throughout the lifetime of an NIHR award. The webinar will be presented by Ian Dowling, Assistant Director - Operations at the NIHR Trainees Coordinating Centre and Sharon Hammond, Finance & Contracts Manager at the NIHR Trainees Coordinating Centre.
It will include:
- practical advice on how to get your finances right from application and throughout an NIHR award
- best practice around monitoring and reporting
- a live Q&A session
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Fellowship and Career Development Opportunities
NIHR Fellowships Funding Opportunities (Fellowships)
Postdoctoral fellowships Stroke Association, GB
The Stroke Association invites applications for its postdoctoral fellowships. These enable postdoctoral candidates from the nursing or allied health professions to conduct an independent research project under the supervision of an established member of the stroke research community.
Closing date: 02 Nov 16
MORE>>>
Senior research fellowship Arthritis Research UK, GB
Arthritis Research UK invites applications for its senior research fellowship. This supports medical or science graduates committed to a research career in any discipline relevant to arthritis and related musculoskeletal diseases
Closing date: 11 Nov 16 (Forecast)
MORE>>>
Clinical research career development fellowship Wellcome Trust, GB
The Wellcome Trust invites preliminary applications for its clinical research career development fellowships. These enable medical, dental, veterinary and clinical psychology graduates to continue research at postdoctoral level while developing scientific independence.
Closing date: 14 Nov 16
MORE>>>
Sir Henry Dale fellowships Wellcome Trust, GB
Applicants must not have more than seven years postdoctoral research experience or hold an established post. They must have sponsorship from a head of department at an eligible host organisation in the UK who must guarantee the fellow with support to lead their own independent research, space and resources during the award period, and the status and benefits of other academic staff of similar seniority. Applicants must have an eligible research project, ranging from molecules and cells to clinical and public health research.
Closing date: 23 Nov 16
MORE>>>
NIHR Research professorships
The Department of Health’s National Institute for Health Research invites applications for its research professorships.
These enable early-career academics to spend a fixed five-year period on translational research at professorial level, and to facilitate strong research leadership and develop research capacity in areas critical to accelerating the transfer of research ideas into improved health.
Closing date: 16 Dec 16 (Forecast)
MORE>>>
Future leaders fund 2016 NIHR Clinical Lectureships (Medical)
NIHR Clinical Lectureships (CLs) are specialty training posts that incorporate academic training. NIHR Clinical Lecturers (CLs) spend 50% of their time undertaking specialist clinical training and 50% undertaking research or educational research training.
CLs are aimed at those who are advanced in their specialty training, have completed a research doctorate or equivalent and show outstanding potential for continuing a career in academic medicine. The duration of a CL is for a maximum of 4 years and it is expected that CLs will complete their specialty training during this period. Alongside clinical training, CLs will be able to further develop their academic skills and will be encouraged to apply for funding to support further Post-Doctoral or educational research training.
Closing date: 31 March 17
MORE>>>
Population research postdoctoral fellowship Cancer Research UK, GB
This enables postdoctoral researchers to develop their careers in the field of population research. The fellowship is awarded for three years and covers salary for the fellow and research expenses.
Maximum award: Not known
Closing date: 07 Nov 16 (recurring)
MORE>>>
MRC Clinical Research Training Fellowship (CRTF)
The MRC CRTF supports clinically active professionals within the UK to undertake a higher research degree. The scheme can also provide post-doctoral funding for applicants who achieved their PhD more than five years ago but who have not been research active since due to clinical training commitments.
Applications are welcome across all areas of the MRC’s remit. Applications may range from basic studies with relevance to mechanisms of disease to translational and developmental clinical research.
The CRTF provides between two and three years’ support. A further year’s funding is available for patient-orientated CRTFs where the project will require significant amounts of patient contact. MORE>>>
Pre-doctoral fellowships: the CRTF provides a competitive personal salary up to but not including NHS consultant level, and funding of up to £20,000 per year. This may cover consumables, equipment, conference travel, PhD and other course fees.
Post-doctoral fellowships: the fellowship provides a competitive personal salary, up to but not including NHS consultant level, research expenses, and travel costs at an appropriate level for the research, under full economic costs (FEC).
Closing date: 12 Jan 2017
MORE>>>
The Academy of Medical Sciences’ Springboard scheme
Springboard awards provide up to £100,000 over two years and a personalised package of career support to help newly independent biomedical scientists launch their research careers.
To be eligible to apply you must:
Hold an established academic research position at your institution.
Be in your first independent (salaried) position (i.e. group leader level) and
Be within 3 years (FTE) of appointment to this position.
Have sufficient time remaining in your current post to complete the proposed Springboard project.
Be based within one of the eligible higher education institutions.
And you must not:
Hold a clinical contract.
Be in receipt of substantial research funding as the Principal or Co-Investigator exceeding £75,000 p.a. (excluding your personal salary).
Eligible institutions may put forward up to three applications per round; you must be nominated by your institution in order to submit an application to the Academy.
When a round is open, prospective applicants should first contact the Springboard Champion within their HEI to express their interest in the scheme and find out how their internal selection will operate.
Closing date for Eligibility check forms: 19 Oct 2016
MORE>>>
Clinical research career development fellowship Wellcome Trust, GB
The Wellcome Trust invites preliminary applications for its clinical research career development fellowships. These enable medical, dental, veterinary and clinical psychology graduates to continue research at postdoctoral level while developing scientific independence.
Closing Date: 14 Nov 16
MORE>>>
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Research News
The UKCRC Tissue Directory is now Live!
Following the successful registration of more than 50 biobanks, the UK Clinical Research Collaboration has launched an online directory of biobanks. Please see links below for further details:
https://www.biobankinguk.org/tissue-directory-now-live/
http://www.mrc.ac.uk/news/browse/online-directory-of-biobanks-established/
Department for Business, Innovation and Skills was replaced by Department for Business, Energy and Industrial Strategy
The Department for Business, Innovation and Skills (BIS) and the Department of Energy and Climate Change (DECC) have merged to form the Department for Business, Energy and Industrial Strategy (BEIS). Please see link below for further details:
https://www.gov.uk/government/organisations/department-for-business-innovation-skills
Progress report on the UK 5 year AMR strategy: 2015
The second annual progress report describes what was achieved in the second year of implementation, including a number of significant achievements on the international stage. Please see link below for further details:
https://www.gov.uk/government/publications/progress-report-on-the-uk-5-year-amr-strategy-2015
Government’s progress in preventing drug resistant infections
The UK continues to work towards preventing antimicrobial resistance (AMR) by investing in new diagnosis tests and vaccines. Please see link below for further details:
https://www.gov.uk/government/publications/progress-report-on-the-uk-5-year-amr-strategy-2015
MHRA response to Brexit
https://www.gov.uk/government/news/medicines-and-healthcare-products-regulatory-agency-statement-on-the-outcome-of-the-eu-referendum
EQUATOR Network newsletter (August 2016 issue)
http://www.equator-network.org/2016/08/18/equator-network-newsletter-august-2016/
It includes information about:
* Taking research to the next level with the EQUATOR Publication School
* PAHO and EQUATOR Network provide tools in Portuguese
* Record access recorded for reporting guidelines on the EQUATOR website
* 2-day workshop with EQUATOR Australasia
* EQUATOR Network opens survey of HRA stakeholders
* EQUATOR Oncology Project Current Awareness Bulletin
* 2017 EQUATOR Publication School
* Guidelines for Accurate and Transparent Health Estimates Reporting
* New reporting guidelines added
Recommendations addressing measurement of gender inequality in medical research published
16 August 2016
Guidelines on how to measure the involvement of women in medical research more accurately have been published, as an output of research funded by the NIHR Oxford Biomedical Research Centre
NIHR i4i Challenge Award for preventative osteoporosis treatment
29 July 2016
The University of Nottingham will undertake a study to develop injectable stem cell-carrying materials to treat and prevent fractures caused by osteoporosis and other bone-thinning diseases after securing i4i Challenge Award funding.
News story: New £816 million investment in health research
14 September, 2016 at 12:15am
Research into mental health, dementia and antimicrobial resistance among the projects funded by £816 million investment in NHS research.
National Institute for Health Research News
New competition announced to boost research in medtech and diagnostic tests
08 September 2016
New, open competition to designate and fund NIHR MedTech and In Vitro Diagnostic Co-operatives (NIHR MICs) to be launched.
NIHR highlights research that could improve diabetes care and prevention02 September 2016
On the Level – Evidence for Action on Type 2 Diabetes aims to help GPs and other healthcare professionals act on the latest type 2 diabetes research. It includes findings from over 30 NIHR research projects
Living with dementia: life story work could help
07 September 2016
A new study has found that life story work has the potential to help people with dementia.
Life story work involves helping people to record aspects of their past and present lives along with future hopes and wishes, often in a book or folder or, increasingly, in music, film and multi-media formats.
Improving the use of antibiotics in children with respiratory tract infections
05 September 2016
Researchers at the University of Bristol funded by an NIHR Programme Grant have developed a technique to help GPs identify which children with coughs and respiratory tract infections (RTIs) are most at risk of future hospitalisation.
World's most in depth study to detect early signs of Alzheimer's disease
22 August 2016 £6.9 million project designed to identify biomarkers which can detect Alzheimer’s disease at an early stage announced.
Clinical trials for medicines: authorisation assessment performance
This data sets out the number of applications assessed by MHRA, split by phase and commercial and non-commercial sponsors. Updated 7th October 2016 |
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Articles
Reporting of clinical trials in nursing journals: how are we doing?
Gray R, Badnapurkar A, Thomas D. Journal of Advanced Nursing, September 2016, online advance publication,
The significant impact of education, poverty, and race on Internet-based research participant engagement.
Hartz SM, Quan T, Ibiebele A, Fisher SL, Olfson E, Salyer P, Bierut LJ.
Genetics in Medicine (2016) doi:10.1038/gim.2016.91
Recommendations to improve adverse event reporting in clinical trial publications: a joint pharmaceutical industry/journal editor perspective
Lineberry N, Berlin JA, Mansi B, Glasser S, Berkwits M, Klem C et al. BMJ 2016; 355 :i5078
Ghostwriting: the importance of definition and its place in contemporary drug marketing.
Matheson A. BMJ 2016; 354 doi: http://dx.doi.org/10.1136/bmj.i4578 (Published 30 August 2016). There is a letter in response at http://www.bmj.com/content/354/bmj.i5043.
Discontinuation and Nonpublication of Randomized Clinical Trials Conducted in Children
Pica N, Bourgeois F. Pediatrics, August 2016 (early publication)
Clinical Trials, Healthy Controls, and the Birth of the IRB
Stark L, Greene JA. . N Engl J Med 2016; 375:1013-1015
The NEJM’s series “The Changing Face of Clinical Trials” is available at http://www.nejm.org/page/clinical-trials-series. Recent articles include “Considerations when the primary outcome is positive” and “The primary outcome fails: what next?”
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To access full text you may have to log in to your NHS Athens account (click here to register for free). If full text is not available then please email us to request a copy.
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Resources used:
BMJ
CASP UK
Community Tool Box
Equator Network
International Committee of Medical Journal Editors
JISCMAIL discussion lists: evidence-based-health, lis-medical, lis-nursing
Journal of Patient Safety
KevinMD
The King's Fund
Medical Research Council
National Institute for Health Research
NIHR, Research Design Service for the East Midlands
School of Health and Related Research, The University of Sheffield
STAT Morning Rounds
UK Clinical Research Collaboration Update
University of Oxford
Links checked: 12th October 2016
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