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Rheumatology Evidence Update

October 2016

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Find out about the Teaching Improvement Course offered by UHL Clinical Education
Announcement

Healthcare Databases Advanced Search.

The Healthcare Databases Advanced Search (HDAS)  now has a new look.
HDAS which allows you to search for content across Healthcare databases such as Medline, Embase, PsychInfo and British Nursing Index has been redesigned. The UHL Libraries and Information Services are offering training over the next 3 weeks on using the new system.
For further information please see
here.
 

Oxycodone for pain in fibromyalgia in adults
Authors' conclusions:There is no randomised trial evidence to support or refute the suggestion that oxycodone, alone or in combination with naloxone, reduces pain in fibromyalgia.

Non-steroidal anti-inflammatory drugs for sciatica
Authors' conclusions: This updated systematic review including 10 trials evaluating the efficacy of NSAIDs versus placebo or other drugs in people with sciatica reports low- to very low-level evidence using the GRADE criteria. The efficacy of NSAIDs for pain reduction was not significant. NSAIDs showed a better global improvement compared to placebo. These findings must be interpreted with caution, as the level of evidence according to the GRADE classification was very low for the outcome pain reduction and low for global improvement due to small study samples, inconsistent results, imprecision, and a high risk of bias in the included trials. While the trials included in the analysis were not powered to detect potential rare side effects, we found an increased risk for side effects in the short-term NSAIDs use. As NSAIDs are frequently prescribed, the risk-benefit ratio of prescribing the drug needs to be considered.

Certolizumab pegol for treating rheumatoid arthritis after inadequate response to a TNF-alpha inhibitor

Secukinumab for active ankylosing spondylitis after treatment with non-steroidal anti-inflammatory drugs or TNF-alpha inhibitors
Primary Research and Evidence Syntheses

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Medication adherence in patients with rheumatoid arthritis: why do patients not take what we prescribe?

The critical role of epigenetics in systemic lupus erythematosus and autoimmunity.

Efficacy and safety of infliximab in psoriatic patients over the age of 65.

Functions of the inner ear in psoriatic arthritis.


The antiphospholipid syndrome in patients with systemic lupus erythematosus.

Update on Importance of Diet in Gout.

Cardiovascular risk assessment in patients with rheumatoid arthritis: The relevance of clinical, genetic and serological markers.

Randomized trial of switching from prescribed non-selective non-steroidal anti-inflammatory drugs toprescribed celecoxib: the Standard care vs. Celecoxib Outcome Trial (SCOT).

Infections as a cause of autoimmune rheumatic diseases.


Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin.

The Clinical and Cost Effectiveness of Apremilast for Treating Active Psoriatic Arthritis: A Critique of the Evidence.

Comparative effects of biologics on cardiovascular risk among older patients with rheumatoid arthritis

Premedication prevents infusion reactions and improves retention rate during infliximab treatment.

A Clinical Study Evaluating the Effects of Fluvastatin on Serum Osteoprotegerin  Levels in  Rheumatoid Arthritis  Patients.

Novel algorithms for the pragmatic use of ultrasound in the management of patients with rheumatoidarthritis: from diagnosis to remission.

Baricitinib in patients with inadequate response or intolerance to conventional synthetic DMARDs:results from the RA-BUILD study.

Non-TNF-Targeted Biologic vs a Second Anti-TNF Drug to  Treat Rheumatoid  Arthritis  in  Patients  With  Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial

Sulfasalazine induced immune thrombocytopenia in a patient with rheumatoid arthritis.


Phytoconstituents as pharmacotherapeutics in rheumatoid arthritis:challenges and scope of
 nano/submicromedicine in its effective delivery.


Clinical and radiographic outcome of a treat-to-target strategy using methotrexate and intra-articular glucocorticoids with or without adalimumab induction: a 2-year investigator-initiated, double-blinded, randomised, controlled trial (OPERA).

The Clinical and Cost Effectiveness of Apremilast for Treating Active Psoriatic Arthritis: A Critique of the Evidence.
UpToDate

What's new in Rheumatology
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Other Reports/News

The EULAR  has a new recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other inflammatory joint diseases.

Read recommendation here.

Hip replacements 'do not necessarily lead to increased physical activity

High cholesterol 'may play a role in onset of osteoarthritis
Do you have any research needs? 
Please contact your Rheumatology Clinical Librarian, Pip Divall on 0116 250 2309 or Pip.Divall@uhl-tr.nhs.uk
Table of Contents
Best Practice and Research Clinical Rheumatology
Clinical Rheumatology
Current Rheumatology reports
Journal of Clinical Rheumatology
Journal of Rheumatology
Modern Rheumatology
Pediatric Rheumatology
Rheumatology
Rheumatology International
Our mailing address is: pip.divall@uhl-tr.nhs.uk
 
Copyright © 2016 UHL Clinical Librarian Service, All rights reserved.
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