Gastroenterology Evidence Update - October 2016- UHL Clinical Librarian Service

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Gastroenterology Evidence Update

26th October 2016

Training on new HDAS database searching for UHL staff
HDAS allows you to search for content across Healthcare databases such as Medline, Embase, PsychInfo and British Nursing Index.
HDAS has been redesigned and UHL Libraries and Information Services are offering training over the next 3 weeks on using the new system.
For further information see here.

Elbasvir–grazoprevir for treating chronic hepatitis C

Coeliac disease

Acute upper gastrointestinal bleeding in over 16s: management

Leicester Publications

The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000-2015).

Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis.

Barrett's oesophagus patients attending hospital: Baseline clinical, patient history and quality of life data from BOSS and AspECT

New and Updated Cochrane Systematic Reviews

Oral 5-aminosalicylic acid for maintenance of medically-induced remission in Crohn's disease
Authors' conclusions: We found no evidence in this review to suggest that oral 5-ASA preparations are superior to placebo for the maintenance of medically-induced remission in patients with Crohn's disease. Additional randomised trials may not be justified.

Non-steroid anti-inflammatory drugs for biliary colic
Authors' conclusions: NSAIDs have been assessed in relatively few trials including a limited number of participants for biliary colic, considering its common occurrence. We found only one trial to be at low risk of bias. There was no mortality. None of the included trials reported quality of life. The generalisability of the review is low as most of the RCTs included neither elderly people nor participants with comorbidities, who are more prone to complications as compared to others with biliary colic.

The beneficial effect of NSAIDs compared with placebo on pain relief was confirmed when we applied Trial Sequential Analysis. The quality of evidence according to GRADE criteria was moderate for the comparison of NSAIDs versus placebo regarding the outcome lack of pain relief and low or very low for the other outcomes and comparisons.

We found only one trial at low risk of bias, following the predefined 'Risk of bias' domains. We found the risk of selection bias to be unclear in nine studies due to poor reporting, leading to uncertainty in the pooled effect estimates.

**Have you seen...Cochrane Clinical Answers in Gastroenterology**

Core (Digestive Disorders Foundation charity)

Core's Fellowship Awards are now open for applications

The Core-Derek Butler Fellowship
Applications are invited for the Core – Derek Butler Fellowship. This is a 3-year full-time fellowship for research into diseases of the upper gastrointestinal tract including cancer. Research should be on the oesophagus, stomach or duodenum.The total value of the fellowship is £210,000 to cover salary costs and consumables over 3 years.
Closing date: 16th December 2016. Interviews: 21st February 2017.

The Core-Amelie Waring Fellowship
Applications are invited for a 3-year full-time fellowship for research into any aspect of pancreatic inflammation or injury.The total value of the fellowship is £180,000 to cover salary costs and consumables over 3 years.
Closing date: 16th December 2016. Interviews: 21st February 2017.

PubMed Search

Click here to be taken to the full results of a PubMed search which includes relevant Systematic Reviews. A selection are included below:

Ursodeoxycholic Acid in Treatment of Non-cholestatic Liver Diseases: A Systematic Review.

<i>PNPLA3</i> as a Genetic Determinant of Risk for and Severity of Non-alcoholic Fatty Liver Disease Spectrum.

Carbohydrate and protein intake and risk of ulcerative colitis: Systematic review and dose-response meta-analysis of epidemiological studies.

Meta-Analysis of Early Nutrition: The Benefits of Enteral Feeding Compared to a Nil Per Os Diet Not Only in Severe, but Also in Mild and Moderate Acute Pancreatitis.
Novel investigational therapies for treating biliary tract carcinoma.

Transient elastography for the diagnosis of liver fibrosis: a systematic review of economic evaluations.

Influence of IL10 Gene polymorphisms on the sustained virologic response of patients with chronic hepatitis C to PEG-interferon/ribavirin therapy.

The role of dietary supplements in inflammatory bowel disease: a systematic review.

Update on Hepatitis C treatment: Systematic review of clinical trials.

Combining aneuploidy and dysplasia for colitis' cancer risk assessment outperforms current surveillance efficiency: a meta-analysis.

Toward an Algorithm for the Diagnosis and Management of CMV in Patients with Colitis.

Efficacy, safety and immunogenicity of biosimilars in inflammatory bowel diseases: A systematic review.

Endoscopic and pharmacological treatment for prophylaxis against postendoscopic retrograde cholangiopancreatography pancreatitis: a meta-analysis and systematic review.

UpToDate - What's new in gastroenterology and hepatology

Sofosbuvir-velpatasvir for all genotypes of chronic HCV infection

NHS Behind the Headlines - media stories explained

Women now drinking 'almost as much alcohol as men'

Gut bacteria may be linked to 'dangerous' body fat

Table of Contents
Alimentary Pharmacology and Therapeutics
American Journal of Gastroenterology
Clinical Gastroenterology and Hepatology
Endoscopy
Gastroenterology
Gastrointestinal Endoscopy
Gastroenterology Nursing
Gastrointestinal Nursing
Gut
Hepatology
Journal of Gastroenterology
Journal of Hepatology
Nature Reviews Gastroenterology and Hepatology
Seminars in Liver Disease

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