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Research Evidence Update
December 2016
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Grants/ Funding/ Opportunities
NIHR Efficacy and mechanism evaluation programme – researcher-led workstream: 16/126
Supporting translational research into interventions that are based or used by the NHS and its partners, and that adopt novel and efficient study designs or that include and embedded methodological study.
Closing date: 14th March 2017
MORE>>>
Efficacy and Mechanism Evaluation Programme – Commissioned calls
16/129 - Epilepsy
16/128 - Improving Safety and Efficacy Through Targeted Drug Delivery
16/127 - Novel Interventions for Treatment Resistant Depression
16/125 - Mechanisms of action of health interventions
Closing date: 14th March 2017
MORE>>>
NIHR Programme development grants
For preparatory work towards grant proposals in the field of applied heath research. Grants are worth between £20,000 and £100,000 each over six to 18 months.
Closing date: 23 Mar 17 (recurring)
MORE>>>
NIHR i4i Mental Health Challenge Award launch event
Proposals are invited for the development of innovative technological solutions that can influence the care pathway and improve patient outcomes for mental health conditions.
Closing date: Wednesday 5 April 2016
MORE >>>
MRC Public Health Intervention Development (PHIND) scheme
Supports the early stages of development of interventions that address an important UK or global public health issue.
Closing date: Thursday 12 January 2017,
MORE>>>
Alzheimer’s Research UK Prevention and Risk Reduction Fund
Funds for research that has the potential to significantly alter the course of cognitive decline in populations that are at-risk of Alzheimer’s disease and/or other dementias.
Closing date: Friday 31 March 2017.
MORE>>>
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If you have a colleague who would like to be added to the Research Evidence Update circulation list, please contact the Clinical Librarian Service.
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Funding Opportunities (Fellowships)
Cancer Research UK, Career development fellowship
This enables scientists to set up their first independent cancer research group in any area of CRUK’s funding remit, with the exception of drug discovery and clinical trials. The fellowship covers salaries for the fellow, one postdoctoral researcher and one technician, and associated running expenses and equipment costs of up to £25,000 over a maximum period of six years. An annual salary enhancement of £6,500 is paid each year of the funding period.
Maximum award: Not known
Closing date: 06 Feb 17 (recurring)
MORE>>>
Cancer Research UK, Senior cancer research fellowship
This enables scientists to establish or further develop an independent cancer research group in any area of the CRUK’s funding remit, with the exception of clinical trials and drug discovery. The fellowship is awarded for a period of six years and comprises salary costs for the fellow, two postdoctoral researchers, a technician and a PhD student, running expenses, and equipment costs of up to £50,000. An annual salary enhancement of £10,500 is paid each year of the funding period.
Maximum award: Not known
Closing date: 06 Feb 17 (recurring)
MORE>>>
Wellcome Trust, Principal research fellowships
The fellowship is for an initial period of seven years or five if applicants hold a UK based senior research fellowship, this includes a basic salary, personal removal expenses and research expenses.
Maximum award: Not known
Closing date: None
MORE>>>
MRC joint research training fellowships
These UK fellowships are provided through collaborations with Royal Colleges and charities and enable support for completing a fellowship, reporting a project, presenting work or for professional networking.
Closing date: 17 January 2017
MORE>>>
National Centre for Research Methods PhD in research methods development
Expressions of interest invited from PhD applicants interested in research methods development as a significant part of their study. MORE>>>
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Writing Club
We hold lunchtime meetings on a range of topics for clinicians who are interested in Writing for Publication.
Further details can be found here or email us to be added to the mailing list
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Training / Events
Advanced Simulation Methods (3 day course)
Tuesday, 24th - Thursday, 26th January 2017
Experiential Research Approaches (ERA): Qualitative methods using observation, description and interpretation (2 day course)
Wednesday, 1st - Thursday, 2nd February 2017
The Application of Psychometrics for Measuring Health Outcomes and Quality of Life (2.5 days course)
Monday, 13th - Wednesday, 15th February 2017
The Application of Psychometrics for Assessing Health Outcomes and Quality of Life (2.5 days course)
Wednesday, 15th - Friday, 17th February 2017
A Guide to doing Mixed Methods in the Health Sciences - Thursday, 19th January 2017
Instant Evidence Based Medicine: how to critically appraise research - Tuesday, 28th February 2017
Real World Evaluation: Ten Key Principles for Evaluating Complex Health and Social Interventions - Thursday, 2nd - Friday, 3rd March 2017
Utility Data for Health Technology Assessment - Monday, 13th - Tuesday, 14th March 2017
The Identification and Review of Evidence to Inform Cost Effectiveness Models - Thursday, 23rd March 2017
ScHARR Systematic Reviews and Meta-analysis Short Course - Tuesday, 4th - Thursday, 6th April 2017
Instant Evidence Based Medicine: how to quickly synthesise research - Tuesday, 9th May 2017
An Introduction to using Social Media to Communicate Research - Thursday, 24th November 2017
Identifying the Evidence for Systematic Reviews - Tuesday 28th March 2017 9.00 am – 4 pm
The course will be led by:
• Carol Lefebvre, Co-Convenor of the Cochrane Information Retrieval Methods Group
• Melissa Harden, Information Specialist at Centre for Reviews & Dissemination
• Kath Wright, Information Services Manager at the Centre for Reviews & Dissemination
Further information about content of the course: 01904 321040 or e-mail: crd-support@york.ac.uk
To book a place on the course please complete and return the booking form
Upcoming Events (RDSEM)
For more details about events please see our website
New MSc in EBHC Systematic Reviews
from The Graduate School of EBM and Research Methods
Evidence-Based Health Care Programme, University of Ocford
This is a course for health professionals who want to gain an understanding of the importance of systematic reviews in health care as well as the practical skills to conduct them. Students will be provided with training in the fundamental principles of evidence-based health care and research design as well as more specific training in the conduct of basic and
more complex systematic reviews
Applications open now for academic year 2017/18. First application deadline: 20 January 2017.
Statistical methods for HTA and evidence based medicine 9 January - 24 March 2017
A new online CPD course is being offered by HEHTA from January 2017.
The course will deliver the fundamentals of statistical methodology that underpin health technology assessment and evidence based medicine. It will include summarising data, Frequentist and Bayesian approaches, probability and probability distributions, measures of effect size, linear and logistical regression, fundamentals of survival analysis.
Part of the MSc in Health Technology Assessment, see www.gla.ac.uk/hta
HTA in a global context 9 January - 24 March 2017
A new online CPD course is being offered by HEHTA from January 2017.
This course will cover HTA in different contexts, exploring geographical variation between high-income countries as well as looking more in-depth about how and why decision-making in healthcare may differ in low- and middle- income countries. It will look at the differences in structure of health care and reimbursement systems, HTA in decision making from a global perspective, Disability Adjusted Life Years (DALYs) as health outcome measures, application of different methods in low and middle income countries (LMICs).
Part of the MSc in Health Technology Assessment, see www.gla.ac.uk/hta
Courses at the Statistical Advisory Service at Imperial College London
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To access full text you may have to log in to your NHS Athens account (click here to register for free). If full text is not available then please email us to request a copy.
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Research News
RDSEM Autumn newsletter with special feature on 'Logic Models' along with 'Tips for funding success.
Survey opportunity: Using digital technology in health research
The CRN's Accelerating Digital Programe, together with the NIHR Evaluation Trials and Studies Coordinating Centre (NETSCC), has developed a survey to understand how digital technologies are currently being used to support clinical research studies and identify opportunities moving forwards.
NIHR BioResource calling for researchers to sign up and access their volunteers
The NIHR BioResource is a database of over 100,000 volunteers, both with and without health conditions, who are willing to be approached to take part in research studies. With the capacity to support more studies, the BioResource is looking for eligible research projects to sign up and use the service. The NIHR BioResource speeds up the process of the study recruitment by targeting specific cohorts of people based on the data, samples and health-related information provided and according to study criteria provided by researchers. Each volunteer has provided a blood or saliva sample and completed a health questionnaire to match them to relevant studies.
Doctors name treatments that bring little or no benefit
Medical experts from 11 different specialties were asked to identify five treatments or procedures commonly used in their field that were not always necessary or valuable. The advice, drawn up by the Academy of Medical Royal Colleges, features on a list of 40 treatments that bring little or no benefit to patients.
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Articles
The NEJM’s series “The Changing Face of Clinical Trials” is available at http://www.nejm.org/page/clinical-trials-series. Recent articles include:
- Lessons from Clinical Trials Involving Hypertension November 3, 2016 | M.A. Pfeffer and J.J.V. McMurray. Ethical issues can arise in the design and conduct of clinical trials. Using the trials that set the stage for our current treatment of hypertension, the authors show how the changing treatment landscape raised ethical problems as these trials were undertaken.
- Data Monitoring Committees — Expect the Unexpected October 6, 2016 | D.L. DeMets and S.S. Ellenberg. Randomized clinical trials require a mechanism to safeguard the enrolled patients from harm that could result from participation. This article reviews the role of data monitoring committees in the performance of randomized clinical trials.
The Equator Oncology Project’s What’s New page lists recent articles about statistical issues, trial design and trial outcomes.
Agreement of treatment effects for mortality from routinely collected data and subsequent randomized trials: meta-epidemiological survey
Lars G Hemkens, Despina G Contopoulos-Ioannidis, John P A Ioannidis
Publication and reporting of clinical trial results: cross sectional analysis across academic medical centers
Ruijun Chen, Nihar R Desai, Joseph S Ross, Weiwei Zhang, Katherine H Chau,
Brian Wayda, Karthik Murugiah, Daniel Y Lu, Amit Mittal, Harlan M Krumholz
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Resources used:
BMJ
CASP UK
Community Tool Box
Equator Network
International Committee of Medical Journal Editors
JISCMAIL discussion lists: evidence-based-health, lis-medical, lis-nursing
Journal of Patient Safety
KevinMD
The King's Fund
Medical Research Council
National Institute for Health Research
NIHR, Research Design Service for the East Midlands
School of Health and Related Research, The University of Sheffield
STAT Morning Rounds
UK Clinical Research Collaboration Update
University of Oxford
Links checked: 19th December 2016
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