At this year’s Bioprocess International Conference (4–7 September 2018 in Boston), our CSO, Pete Gagnon presented requirements for platform purification of adeno-associated virus. Viruses can be quite big, they are more vulnerable to shear forces, they are less tolerant of extreme chemical conditions, they are produced at dramatically lower concentrations, they have an elevated tendency to form stable non-specific assocations with contaminants and surfaces, and they are contaminated with empty particles.
This presentation explains why monoliths provide a tool box that is ideally suited to meet these challenges. And it shares a purification platform that accommodates the natural variability among AAV vectors.
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