New Professional Education resources:

• Chapitre 7:  Réduction des agents pathogènes dans les produits de fractionnement (Oct. 28, 2019)

• Surveillance Report 2018 / Rapport de surveillance 2018 (Oct. 17, 2019)

Serological Best Practices:

Testing patients’ blood for non-ABO antibodies determines if they require antigen-negative red blood cell units for transfusion. These best practices provide information about some of these antibodies and the implications for patient management if they are detected. They also include a table summarizing recommendations for red blood cell transfusion in patients with non-ABO antibodies. Available in English and French.

• Rh System:  Anti-V
• Rh System:  Anti-Cw
• Lutheran System:  Anti-Lua
• Kell System:  Anti-Jsa
• Diego System: Anti-Wra
• Diego System:  Anti-Dia
• Kell System: Anti-Kpa (updated)
• Lewis System: Anti-Lewis (updated)
• MNS System: Anti-M (updated)

Posts from the RED blog

New publications

Targeting ABL1 or ARG Tyrosine Kinases to Restrict HIV-1 Infection in Primary CD4+ T-Cells or in Humanized NSG Mice.
McCarthy SDS, Leontyev D, Nicoletti P, Binnington B, Kozlowski HN, Ostrowski M, Cochrane A, Branch DR, Wong RW. J Acquir Immune Defic Syndr. 2019 Dec 1;82(4):407-415. doi:10.1097/QAI.0000000000002144. PMID: 31658184

A case of recurrent transfusion-related acute lung injury despite lessons learned from antibody mitigation.
McVey MJ, Lin Y, Young DK, Cserti-Gazdewich C. Transfus Med. 2019 Oct;29(5):376-378. doi: 10.1111/tme.12628. Epub 2019 Aug 19. No abstract available. PMID: 31429144

Not all red cell concentrate units are equivalent: international survey of processing and in vitro quality data.
Shih AW, Apelseth TO, Cardigan R, Marks DC, Bégué S, Greinacher A, de Korte D, Seltsam A, Shaz BH, Wikman A, Barty RL, Heddle NM, Acker JP; QMiP Investigators on behalf of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Vox Sang. 2019 Oct 22. doi: 10.1111/vox.12836. [Epub ahead of print] PMID: 31637738

Effect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery: The FIBRES Randomized Clinical Trial.
Callum J, Farkouh ME, Scales DC, Heddle NM, Crowther M, Rao V, Hucke HP, Carroll J, Grewal D, Brar S, Bussières J, Grocott H, Harle C, Pavenski K, Rochon A, Saha T, Shepherd L, Syed S, Tran D, Wong D, Zeller M, Karkouti K; FIBRES Research Group. JAMA. 2019 Oct 21:1-11. doi: 10.1001/jama.2019.17312. [Epub ahead of print] PMID: 31634905

Overcoming the deceptively low viability of CD45+ cells in thawed cord blood unit segments. Pasha R, Halpenny M, Pineault N. Vox Sang. 2019 Oct 17. doi: 10.1111/vox.12844. [Epub ahead of print] PMID: 31625187

Bacterial survival in whole blood depends on plasma sensitivity and resistance to neutrophil killing. Taha M, Kyluik-Price D, Kumaran D, Scott MD, Toyofuku W, Ramirez-Arcos S. Transfusion. 2019 Oct 13. doi: 10.1111/trf.15550. [Epub ahead of print] PMID: 31608457

Systematic review of controlled clinical studies using umbilical cord blood for regenerative therapy: Identifying barriers to assessing efficacy. Aziz J, Liao G, Adams Z, Rizk M, Shorr R, Allan DS. Cytotherapy. 2019 Oct 3. pii: S1465-3249(19)30843-6. doi: 10.1016/j.jcyt.2019.08.004. [Epub ahead of print] Review. PMID: 31587876

Reducing AB plasma utilisation through the AB plasma appropriateness index. Al Khan S, Rosinski K, Petraszko T, Dawe P, Hwang BW, Sham L, Hudoba M, Roland K, Shih AW. Transfus Med. 2019 Oct 1. doi: 10.1111/tme.12632. [Epub ahead of print] PMID: 31576629

Using population-wide administrative and laboratory data to estimate type- and subtype-specific influenza vaccine effectiveness: a surveillance protocol. Scott AN, Buchan SA, Kwong JC, Drews SJ, Simmonds KA, Svenson LW. BMJ Open. 2019 Sep 30;9(9):e029708. doi: 10.1136/bmjopen-2019-029708.
PMID: 31575570  Free PMC Article