Six group leaders awarded NHMRC Ideas Grants
EMBL Australia group leaders have been awarded more than $4.3 million in funding for their innovative research through the National Health and Medical Research Council’s Ideas Grant scheme.
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Grant for novel study of brain function using plant receptors
EMBL Australia group leader Dr Harald Janovjak has been awarded a $600,000 ARC Discovery Projects Grant for innovative research that will expand our ability to manipulate nerve cell function with high specificity and without side effects.
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Group Leader position at UNSW
We're looking for a talented early to mid-career researcher with a bold vision for independent research within their field of expertise - including in Synthetic Biology, Cell Biology, Biophysics, Data Science, Structural Biology, and Bioengineering. Sound like you?
See the job ad |
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High hopes for futuristic tissue-healing method
Research led by EMBL Australia group leader Mikaël Martino & published in Nature Biomedical Engineering improves the delivery of growth factors to promote tissue repair, busting cancer side effects and potentially slashing costs.
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Science by the sea:
EMBL Partnership Conference
Members of our Partner Laboratory Network joined researchers from around the world in sunny Barcelona for the 3rd EMBL Partnership Conference, which aimed to foster collaboration within the wider EMBL network.
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Max Cryle to lead Victorian node of new $35 million ARC research centre
EMBL Australia group leader Associate Professor Max Cryle will lead the Victorian node of the new ARC Centre of Excellence for Innovations in Peptide and Protein Science.
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EAPS 2019: Student-run symposium continues to shine
Impressive speakers shared their work and useful career advice with the 120-plus students that attended the 6th annual EMBL Australia Postgraduate Symposium (EAPS), held at the Victorian Comprehensive Cancer Centre in late November.
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Group leader at the EMBL Australia Node in Single Molecule Science (University of New South Wales, Sydney).
Outstanding candidates for post-doc positions are encouraged to contact EMBL Australia group leaders. EMBL Australia groups offer exceptional academic and research environments, with internationally competitive salaries and career-development opportunities.
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Applications for travel grants to train at one of EMBL’s six European facilities, go to a conference or take a short course in the later half of 2020 will open early in the new year.
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The 7th EMBL Australia PhD Course will be held from 13 - 24 July 2020 at the Australian National University (ANU), Canberra. Applications to attend the popular two-week training program will open early in the new year.
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Borreguero-Muñoz N, Fletcher GC, Aguilar-Aragon M, Elbediwy A, Vincent-Mistiaen ZI, Thompson BJ. The Hippo pathway integrates PI3K–Akt signals with mechanical and polarity cues to control tissue growth. PLOS Biology. (2019) 17(10): e3000509.
Boyle MJ, Chan JA, Handayuni I, et al. IgM in human immunity to Plasmodium falciparum malaria. Sci. Adv. (2019) 5(9): eaax4489.
Cordero PRF, Grinter R, Hards K, Cryle MJ, Warr CG, Cook GM & Greening C. Two uptake hydrogenases differentially interact with the aerobic respiratory chain during mycobacterial growth and persistence.
J Biol Chem. (2019) doi: 10.1074.
Coughlan E, Garside VC, Wong SFL, Liang H, Kraus D, Karmakar K, Maheshwari U, Rijli FM, Bourne J & McGlinn E. A Hox Code Defines Spinocerebellar Neuron Subtype Regionalization. Cell Rep. (2019) 29(8): 2408-2421.e4.
Kaniusaite M, Tailhades J, Marschall EA, Goode RJA, Schittenhelmac RB & Cryle MJ. A proof-reading mechanism for non-proteinogenic amino acid incorporation into glycopeptide antibiotics. Chem. Sci. (2019) 10: 9466-9482.
Kumar R, Loughland JR, Ng SS, Boyle MJ & Engwerda CR. The regulation of CD4+ T cells during malaria. Immunol Rev. (2019) doi: 10.1111.
Kurtovic L, Boyle MJ, Opi DH, Kennedy AT, Tham WH, Reiling L, Chan JA & Beeson JG. Complement in malaria immunity and vaccines. Immunol Rev. (2019) doi: 10.1111.
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Recent publications cont.
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Lim Kam Sian TCC, Indumathy S, Halim H, Greule A, Cryle MJ, Bowness P, Rossjohn J, Gras S, Purcell AW & Schittenhelm RB. Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation. J. Biol. Chem. (2019).
doi: 10.1074.
Marschall E, Cryle MJ & Tailhades J. Biological, chemical, and biochemical strategies for modifying glycopeptide antibiotics. J Biol Chem. (2019) doi: 10.1074.
Mochizuki M, Güç E, Park AJ, Julier Z, Briquez PS, Kuhn GA, Müller R, Swartz MA, Hubbell JA & Martino MM. Growth factors with enhanced syndecan binding generate tonic signalling and promote tissue healing. Nat Biomed Eng (2019)
doi: 10.1038/s41551-019-0469-1.
Obeidy P, Ju LA, Oehlers SH, Zulkhernain NS, Lee Q, Galeano Niño JL, Kwan R, Tikoo S, Cavanagh LL, Mrass P, Cook A, Jackson SP, Biro M, Roediger B, Sixt M & Weninger W. Partial loss of actin nucleator Actin Related Protein 2/3 activity triggers blebbing in primary T lymphocytes. Immunol. Cell Biol. (2019)
doi: 10.1111/imcb.12304.
Oyong DA, Loughland JR, SheelaNair A, Andrew D, Rivera FDL, Piera KA, William T, Grigg MJ, Barber BE, Haque A, Engwerda CR, McCarthy JS, Anstey NM & Boyle MJ. Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection. Malar J. (2019)
18: 312.
Pang SS, Bayly-Jones C, Radjainia M, Spicer BA, Law RHP, Hodel AW, Parsons ES, Ekkel SM, Conroy PJ, Ramm G, Venugopal H, Bird PI, Hoogenboom BW, Voskoboinik I, Gambin Y, Sierecki E, Dunstone MA & Whisstock JC. The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1. Nat Commun. (2019) 10: 4288.
Redpath GMI, Ecker M, Kapoor-Kaushik N, Vartoukian H, Carnell M, Kempe D, Biro M, Ariotti N & Rossy J. Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis. Nat Commun. (2019) 10: 4392.
Ryan FJ, Drew DP, Douglas C, Leong LEX., Moldovan M, Lynn M, Fink N, Sribnaia A, Penttila I, Mcphee AJ, Collins CT, Makrides M, Gibson RA, Rogers GB & Lynn DJ. Changes in the composition of the gut microbiota and the blood transcriptome in preterm infants <29 weeks gestation diagnosed with bronchopulmonary dysplasia. mSystems. (2019) 4(5)
pii: e00484-19.
Sidor C, Borreguero-Munoz N, Fletcher GC, Elbediwy A, Guillermin O, Thompson BJ. Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import and stability. eLife. (2019) 8: e48601.
Tailhades J, Zhao Y, Schoppet M, Greule A, Goode RJA, Schittenhelm RB, De Voss JJ, Cryle MJ. Enzymatic Cascade to Evaluate the Tricyclization of Glycopeptide Antibiotic Precursor Peptides as a Prequel to Biosynthetic Redesign. Org. Lett. (2019) 21(21): 8635-8640.
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Senthil
Arumugam
Dr Senthil Arumugam recently joined EMBL Australia as a group leader, based at the Monash Biomedicine Discovery Institute.
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Tell us a little bit about yourself:
I decided to work on bacteria for my PhD because I grew good bacteria (contaminations) in my neuronal cultures during my master's and was fascinated by how robustly they divided.
What are your scientific interests?
I am fascinated by how single cells sense and interpret signals and how, when they are in multi-cellular environments, complex patterning can emerge.
Which unresolved question would you most like to answer?
I would love to understand the molecular basis and mechanism of how neuronal cells store information (i.e. how do our brains form memories?). But one has to be pragmatic with the available background knowledge, experimental resources etc. So, how cells process signals and coordinate with each other to produce complex life forms as we know them is my measured but ambitious question of choice.
What will you be looking for as you build your group?
Realisation and adaptability. Our work is interdisciplinary: there needs to be understanding and communication between people coming from varied academic training. For example, physicists and biologists need to be able to understand each other’s concepts, even if they are limited on how much they can actually do. They must realise the bigger potential, perspective and quality of work that comes from working together.
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What are your goals for your group?
Generally, we want to do better imaging of more relevant biological samples to understand complex processes in nature.
Better imaging for us equals technologies that enable observing molecules in action with better precision and speed in a living organism. We have previously worked on cell lines, but are very keen to get on to organoids and organisms that are much more relevant.
Ultimately, we hope to lead the way in discovering principles in operation in biological organisms at various scales, with the aim of furthering fundamental knowledge and understanding of disease mechanisms.
Name one tool you can’t do without.
There is not one, but many. Microscopes, lasers, computers, dyes, everything. But I would just say 'coffee' here.
What’s the best advice you’ve ever received?
This was from Tom Kirchhausen at Harvard. After I got my first independent group leader position, I asked if he had any advice for me. He said: "You are your lab’s best postdoc."
More about Senthil's research
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