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Sara Osum, PhD candidate, gave platform presentation entitled "Investigating the role of NF1 +/- haploinsufficient fibroblasts in neurofibromatosis type 1-associated tumors" at the Annual Neurofibromatosis Conference, San Francisco, CA, September 2019.
Mike Olin, PhD, gave presentation entitled "Emerging Target Therapies in Cancer: Toward effective combinations," Santa Maria, Cuba, October 2019.
Mike Olin, PhD, gave presentation entitled "Overpowering multiple inhibitory immune checkpoints with a single peptide inhibitor enhanced survival in a spontaneous high-grade glioma canine pilot-trial" at the SNO-SCIDOT Joint Conference on Therapeutic Delivery to the CNS, Phoenix, AZ, November 2019.
Clark Chen, MD, PhD, gave presentations entitled "Immuno-stimulation through surgically administered mechanical high intensity focused ultrasound" and "Interim results of a phase II multi-center study of oncolytic adenovirus DNX-2401 with pembrolizumab for recurrent glioblastoma; CAPTIVE study" and "Clinical Applicaation of GammaTile in Neuro-Oncology: Initial experience" at the Society for Neuro-Oncology Meeting, Phoenix, AZ, November 2019.
Kathryn Dusenbery, MD, gave presentation entitled "First experience with GammaTile permanent implants for recurrent brain tumors at University of Minnesota" at the Society for Neuro-Oncology Meeting, Phoenix, AZ, November 2019.
David Largaespada, PhD, gave presentation entitled "Using transposon mutagenesis and synthetic lethal screens to find therapeutic targets for sarcoma" at Cedars-Sinai Medical Center, Los Angeles, CA, November 2019.
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David Largaespada receives grant entitled "Predictive Modeling Utilizing a Preclinical NF1-MPNST Platform Suitable for Precision Oncology" from the NF Research Initiative, Division of Genetics and Genomics: MPNST Patient-Derived Model Development and Testing Centers Grant, December 1, 2019.
Clark Chen receives R01 grant entitled "Development of Quantitative Deuterium MRS Imaging for Human Brain Tumor Application at Ultrahigh Field" from the NIH, 2019.
Clark Chen receives grant entitled "Natural Killer (NK) cells as a platform for glioblastoma therapy" from the Ferris Foundation Research Fund, 2019.
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Laser Ablation of Abnormal Neurological Tissue using Robotic Neuroblate System (LAANTERN). Sponsor: Monteris
A Phase II, Multi-center, Open-label Study of a Conditionally Replicative Adenovirus (DNX-2401) with Pembrolizumab (KEYTRUDA®) for Recurrent Glioblastoma or Gliosarcoma. Sponsor: DNATrix therapeutics
MEGA-PRESS in glioma. Sponsor: Investigator initiated
Phase I of Ad-RTS-hIL-12 in glioblastoma. Sponsor: Ziopharm
A phase II, open-label, multi-center study of ONC201 in adults with recurrent high-grade glioma. Sponsor: Oncoceutics
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Evans E, Nascene D, Sommer K, Moertel C. "Autonomic Cross-Innervation in Patients With Neurofibromatosis Type 2: Frey Syndrome and Unilateral Epiphora with Rhinorrhea." Child Neurol Open. 2019 Aug 6; 6: 2329048X19866617. https://doi.org/10.1177/2329048X19866617
Huang M, Tailor J, Zhen Q, Gilmor AH, Miller ML, Weishaupt H, Chen J, Zheng T, Nash EK, McHenry LK, An Z, Ye F, Takashima Y, Clarke J, Ayetey H, Cavalli FMG, Luu B, Moriarity BS, Ilkhanizadeh S, Chavez L, Yu C, Kurian KM, Magnaldo T, Sevenet N, Koch P, Pollard SM, Dirks P, Snyder MP, Largaespada DA, Cho YJ, Phillips JJ, Swartling FJ, Morrissy AS, Kool M, Pfister SM, Taylor MD, Smith A, Weiss WA. "Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis." Cell Stem Cell. 2019 Sep 5; 25(3): 433-446. https://doi.org/10.1016/j.stem.2019.05.013
Hou JC, Shamsan GA, Anderson SM, McMahon MM, Tyler LP, Castle BT, Heussner RK, Provenzano PP, Keefe DF, Barocas VH, Odde DJ. "Modeling distributed forces within cell adhesions of varying size on continuous substrates." Cytoskeleton (Hoboken). 2019 Sep 12. https://doi.org/10.1002/cm.21561
Chahal KK, LI J, kufareva I, Parle M, Durden DL, Wechsler-Reya RJ, Chen CC, Abagyan R. "Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma." PLoS One. 2019 Sep 20; 14(9): e0214901. https://doi.org/10.1371/journal.pone.0214901
Cornax I, Pluhar GE, Clark HB, O'Sullivan MG. "Oligodendroglioma with Neuronal Differentiation in Two Boxer Dogs." J Comp Pathol. 2019 Oct; 172: 11-16. https://doi.org/10.1016/j.jcpa.2019.08.003
Bartek J Jr, Alattar AA< Dhawan S, Ma J, Koga T, Nakaji P, Dusenbery KE, Chen CC. "Receipt of brachytherapy is an independent predictor of survival in glioblastoma in the Surveillance, Epidemiology, and End Results database." J Neurooncol. 2019 Oct; 145(1): 75-83. https://doi.org/10.1007/s11060-019-03268-y
Hemmat M, Castle BT, Sachs JN, Odde DJ. "Multiscale Computational Modeling of Tubulin-Tubulin Lateral Interaction." Biophys J. 2019 Oct 1; 117(7): 1234-1249. https://doi.org/10.1016/j.bpj.2019.08.0111
Liu CJ, Shamsan GA, Akkin T, Odde DJ. "Glioma Cell Migration Dynamics in Brain Tissue Assessed by Multimodal Optical Imaging." Biophys J. 2019 Oct 1; 117(7): 1179-1188. https://doi.org/10.1016/j.bpj.2019.08.010
Shamsan GA, Odde DJ. "Emerging technologies in mechanotransduction research." Curr Opin Chem Bio. 2019 Oct 13; 53: 125-130. https://doi.org/10.1016/j.cbpa.2019.08.002
Xiong Z, Ampudia Mesias E, Pluhar GE, Rathe SK, Largaespada DA, Sham YY, Moertel CL, Olin MR. "CD200 Checkpoint Reversal: A Novel Approach to Immunotherapy." Clin Cancer Res. 2019 Oct 17. https://doi.org/10.1158/1078-0432.CCR-19-2234
Ricard JA, Cramer SW, Charles R, Gil Tommee C, Le A, Bell WR, Chen CC, Flanagan ME. "Infratentorial Glioblastoma Metastasis to Bone." World Neurosurg. 2019 Nov; 131: 90-94. https://doi.org/10.1016/j.wneu.2019.07.142
Randall EC, Lopez BGC, Peng S, Regan MS, Abdelmoula WM, Basu SS, Santagata S, Yoon H, Haigis M, Agar JN, Tran NL, Elmquist WF, White FM, Sarkaria JN, Agar NYR. "Localized metabolomic gradients in patient-derived xenograft models of glioblastoma." Cancer Res. 2019 Nov 25. https://doi.org/10.1158/0008-5472.CAN-19-0638
Kim M, Laramy JK, Gampa G, Parrish KE, Brundage R, Sarkaria JN, Elmquist WF. "Brain Distributional Kinetics of a Novel MDM2 Inhibitor SAR4058: Implications for Use in Brain Tumor Therapy." Drug Metab Dispos. 2019 Dec; 47(12): 1403-1414. https://doi.org/10.1124/dmd.119.088716
Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. "Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair." Cancer Cell. 2019 Dec 9; 36(6): 690-691. https://doi.org/10.1016/j.ccell.2019.11.008
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The Brain Tumor Program Team participated in the American Brain Tumor Association's Brain Tumor 5K on Oct. 12, 2019.
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Jan 9 - BTP Data Club, TBD
Feb 13 - BTP Data Club, Malgorzata Marjanska, PhD
Feb 15 - Cupid Undie Run
March 12 - BTP Data Club, Tomoyuki Koga, MD, PhD
April 6-7 - Neuro-Oncology Symposium
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In Memorium
One of our friends and colleagues, Bryant J. Keller, passed away on Sunday, December 8, from an aneurysm. He was in the 5th year of his PhD training in the MCDB&G program. He will be greatly missed.
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