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COVID-19 and SARS-CoV-2 Updates

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Immunopaedia is committed to bring you COVID-19 and SARS-CoV-2 scientific updates daily. We will be posting breaking news each day about the virus and disease so keep checking Immunopaedia.

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COVID-19 & SARS-CoV-2 NEWS

BCG & COVID-19
Miller et al., (Pre-print) suggest a correlation between BCG vaccination policy and COVID-19. They suggest that high rates of COVID-19 in countries such as Italy, Netherlands and USA, could be related to non-universal BCG vaccination. However, a RCT is required to determine this. - READ MORE

Potent neutralizing antibodies isolated from COVID-19 patients
Bin et al isolated and characterized 206 potential therapeutic and prophylactic monoclonal Abs from 8 COVID-19 patients. The isolated Abs were found to prevent RBD-ACE-2 interaction and to have high binding affinity and neutralizing activity. - READ MORE

The potential benefit of high-dose intravenous Ig in severe COVID-19
Cao et al., describe a promising clinical outcome of three patients presenting with severe COVID-19 and treated with high-dose intravenous immunoglobulin (IVIg). According to the authors "All patients were clinically improved shortly following the administration...- READ MORE

SOLIDARITY TRIAL: Testing existing drugs to treat COVID-19
In an attempt to avoid repeating the mistakes of the 2014–16 West African Ebola epidemic, where clinical trials were set up late, leading to the under-recruiting of patients – in the current pandemic researchers have decided to start trials as soon as possible.- READ MORE

Why is COVID-19 so mild in children?
One explanation for the milder COVID-19 disease presentation in children may be that children have a qualitatively different response to the SARS-CoV2 virus to adults (1). Another possibility is the common simultaneous presence of additional viruses in the mucosa of lungs and airways of young children.- READ MORE

SOLIDARITY TRIAL: WHO COVID-19 treatment trial
In an unprecedented effort to obtain scientific data during the SARS-CoV-2 pandemic, the World Health Organization (WHO) has announced the new SOLIDARITY trial that would include thousands of patients from around the world (45 countries and counting).- READ MORE

OPINION: COVID-19 SPURS INTEREST IN PREPRINTS AND IMPROVES SCIENTIFIC COLLABORATION

Immunopaedia Ambassador Maxwell Chan is an Undergraduate Researcher at the University of Toronto, Canada. Maxwell wrote an opinion piece for Immunopaedia on the benefits of pre-print papers during the current SARS-CoV-2 and COVID-19 pandemic.

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IUIS-FRONTIERS WEBINARS

The situation that we are facing with the COVID-19 pandemic is unprecedented. The International Union of Immunological Societies (IUIS) is collaborating with Frontiers and launching a series of weekly expert commentaries and scientific webinars to accelerate the development of novel diagnostics, therapeutics and vaccines. Tune in to the IUIS-Frontiers scientific webinars!

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