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December 2018
 
english Few days before 2019 we are happy to announce that  BIOMIMESYS® Brain hydroscaffold for neuronal cells will be available next month. We present preliminary results below. Of course, you can already use other BIOMIMESYS® hydroscaffolds for your assays and you can even create your own personalized BIOMIMESYS®! Just contact us! Merry Christmas and Happy New Year!
 
french Quelques jours avant 2019 nous sommes heureux de vous annoncer que BIOMIMESYS® Brain hydroscaffold pour cellules neuronales sera disponible le mois prochain. Nous présentons des résultats préliminaires ci-dessous. Bien sur, vous pouvez déjà utiliser les autres BIOMIMESYS® hydroscaffolds pour vos essais et il est même possible de créer votre propre BIOMIMESYS® hydroscaffold personnalisé. Contactez-nous ! Joyeux Noel et Bonne année !
 
 
BIOMIMESYS® Hydroscaffold for 3D neuronal cell culture: where are we now?
We are developing a new BIOMIMESYS® hydroscaffold for neuronal cells. First results are very promising because neurons grow and form neurites. Moreover cells lived longer than in monolayer culture. We are currently finalizing this new hydroscaffold to find the best conditions of 3D neuron culture, but BIOMIMESYS Brain will be soon on the market!
Mathematical modeling of spheroid formation in BIOMIMESYS
In this article, researchers from Sorbonne University (Paris, France) proposed an explanation for the patterns followed by breast cancer cells when seeded in BIOMIMESYS, i.e. spherical aggregates.
Poster – Characterisation of 3D cultured primary human hepatocytes and HepaRG for DMSO-free preclinical toxicity testing
Hepatocytes in primary cultures are still the gold standard in the pharmaceutical industry ; however they are expensive and have a very short lifespan with a progressive loss of specific functions over time. The dipolar aprotic solvent, dimethyl sulfoxide (DMSO) is wildly used to stabilize the liver specific function of human hepatocytes in vitro. It is also used to potentialize the differentiation of the human HepaRG-hepatocytes-like cells that share functional characteristics with human hepatocytes. Besides its free radicals scavenging properties that contribute to hepatoprotection, DMSO has been shown to interfere with apoptosis signalling pathways. To avoid this disadvantage, we have analysed the functional properties of freshly isolated human hepatocytes (FIH) and HepaRG-hepatocyte-like cells in 3D cultures performed using Ultra Low Attachment Technology (ULA) plates.

Importance of extracellular matrix for neuronal cell growth

Sood et al. published in 2016 an interesting article about the effect of extracellular matrix (ECM) on in vitroneuronal cells culture: Fetal brain extracellular matrix boosts neuronal network formation in 3D bioengineered model of cortical brain tissue “. The aim of the study was to study the effects of fetal and adult ECM and matricellular proteins on neurons by means of an in vitro 3D model.

Feedback from BioFit Lille 2018!
HCS Pharma team enjoyed attending BioFit 2018 and hosted events in Lille last week! Our business developer Nathalie had many fruitful BtoB meetings along the convention, and our study director Elodie could meet lots of people interested in our imaging technology and BIOMIMESYS products while on HCS pharma booth (D4/2) within Lille Northern France Biocluster.
Revision of the guidance for the testing of cosmetic ingredients and their evaluation
On November 7th, the 10th revision of the SCCS's Notes of Guidance has been released. If you work in cosmetology, you know the importance of this document used to "provide guidance to public authorities and to the cosmetic industry in order to improve harmonised compliance with the current cosmetic EU legislation".
How automation will transform the lab of the future
Over the last few years, scientists have discovered connections between gut microbiota imbalances and various diseases. Now, in a study using mice, biologists from the CNRS, INSERM, and Claude Bernard Lyon 1 University—together with colleagues from the Institut Pasteur de Lille and the NIH (USA)—have revealed a surprising relationship between a viral detection system, the composition of the gut microbiota, and the development of skin allergies. Their findings, published in PNAS (September 24, 2018) suggest potential new therapies.
Feedback from HCS Pharma @ HI Europe Frankfurt 2018!
Our study directors Elodie and Pierre-Jean enjoyed the last edition of Health Ingredients Europe, which took place in Frankfurt (Germany) from the 27th to the 28th of November 2018.

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To target complex diseases (as cancer and neurodegenerative diseases), more than one target are needed and screening on complex model is recommended.

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