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Issue 21 - January 2019
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Welcome to the January edition of Tablets, a prescribing newsletter produced monthly by the Medicines Management team at Midlands and Lancashire CSU.

 

Contents

Recommendations

BLACK Acetylcysteine for idiopathic pulmonary fibrosis
The Pan Mersey Area Prescribing Committee does not recommend the prescribing of oral acetylcysteine in idiopathic pulmonary fibrosis.
https://www.panmerseyapc.nhs.uk/media/2097/acetylcysteine_idp.pdf


RED TOFACITINIB film-coated tablets (Xeljanz®▼) for Psoriatic Arthritis
The Pan Mersey Area Prescribing Committee recommends the prescribing of TOFACITINIB tablets (Xeljanz®▼), by specialists only, for treating psoriatic arthritis after inadequate response to DMARDs in accordance with NICE TA543.
https://www.panmerseyapc.nhs.uk/media/2108/tofacitinib_psa.pdf


GREY RIVAROXABAN 2.5mg tablets (Xarelto®▼) for the prevention of atherothrombotic events
The Pan Mersey Area Prescribing Committee does not recommend the prescribing of RIVAROXABAN 2.5mg tablets (Xarelto®▼) for the prevention of atherothrombotic events in adult patients with coronary artery disease (CAD) or symptomatic peripheral artery disease (PAD) at high risk of ischaemic events – in combination with aspirin.
https://www.panmerseyapc.nhs.uk/media/2093/rivaroxaban_ad.pdf


AMBER RETAINED METHADONE tablets (Physeptone®)
The Pan Mersey Area Prescribing Committee recommends the prescribing of methadone tablets (Physeptone®) in adults following initiation by a consultant in pain medicine in a tertiary centre.
https://www.panmerseyapc.nhs.uk/media/2094/methadone.pdf
https://www.panmerseyapc.nhs.uk/media/2095/methadone_support.pdf
https://www.panmerseyapc.nhs.uk/media/2096/methadone_letter.docx


GREEN IVERMECTIN 10mg/g Cream (Soolantra®)
The Pan Mersey Area Prescribing Committee recommends the prescribing of IVERMECTIN 10mg/g cream (Soolantra®) for second line topical treatment of moderate to severe papulopustular rosacea in adult patients.
https://www.panmerseyapc.nhs.uk/media/2092/ivermectin.pdf


Guidelines

DEMENTIA: behavioural and psychological symptoms (BPSD), use of antipsychotics
The Pan Mersey Area Prescribing Committee recommends that antipsychotics prescribed for BPSD should be initiated by a dementia specialist and reviewed in accordance with NICE/SCIE guidelines.
https://www.panmerseyapc.nhs.uk/media/2104/dementia_bpsd.pdf


GENERALISED ANXIETY DISORDER in adults
Pharmacological treatment pathway 2018
https://www.panmerseyapc.nhs.uk/media/2098/gad.pdf


NEUROPATHIC PAIN, pharmacological management in non-specialist settings
This guideline is for use in primary care for initial management, not in specialist pain service settings.
https://www.panmerseyapc.nhs.uk/media/2103/neuropathicpain.pdf


RHEUMATOLOGY high cost drug pathways – sequential options
Additional high-cost drug options harmonised across pathways, if treatment failure occurs due to adverse effects, primary failure or secondary failure.
https://www.panmerseyapc.nhs.uk/media/2099/asaxialspa_pathway.pdf
https://www.panmerseyapc.nhs.uk/media/2101/psaspahighcost_pathway.pdf
https://www.panmerseyapc.nhs.uk/media/2100/rhahighcost_pathway.pdf


RHEUMATOLOGY high cost drug pathways – NHS England commissioning aspects
AOSD – NHS England now commissions anakinra and tocilizumab in AOSD that CCGs in Pan Mersey previously agreed to fund. JIA - NHS England commissions treatment in children, but CCGs commission where any patients move to adult services still requiring treatment.
https://www.panmerseyapc.nhs.uk/media/2073/stills_pathway.pdf
https://www.panmerseyapc.nhs.uk/media/2102/jia.pdf


Formulary

RED TERIPARATIDE for osteoporosis in males
Now commissioned by NHS England. CCGs will no longer fund for treatment in males (PBR excluded drug).
http://formulary.panmerseyapc.nhs.uk/chaptersSub.asp?FormularySectionID=6


AMBER RECOMMENDED Cortiment® (budesonide m/r) for Crohn’s disease
This now an equivalent option to Clipper® (beclomethasone m/r).
http://formulary.panmerseyapc.nhs.uk/chaptersSub.asp?FormularySectionID=1


AMBER RECOMMENDED Pilocarpine tablets for dry mouth caused by irradiation for head & neck cancers and Sjogren’s Syndrome
Change in RAG rating from Red to Amber Recommended to reflect that almost all the prescribing is in primary care.
http://formulary.panmerseyapc.nhs.uk/chaptersSubDetails.asp?FormularySectionID=12&SubSectionRef=12&SubSectionID=A100&FC=1


GREEN Evolve HA® eye drops (sodium hyaluronate 0.2% eye drops) for Dry eyes
Additional lower-cost brand to be 1st-line option. (Evolve HA® £5.99, Hyloforte® £9.50 per 10ml)
http://formulary.panmerseyapc.nhs.uk/chaptersSub.asp?FormularySectionID=11


GREEN GABAPENTIN AND PREGABALIN for restless legs syndrome
Additional RAG designation clarifying as suitable for initiation in primary care for this indication, 2nd line option to dopaminergic agents (off-label indication). Minimal cost implication anticipated.
http://formulary.panmerseyapc.nhs.uk/chaptersSub.asp?FormularySectionID=4v


GREEN ITRACONAZOLE for Chronic pulmonary aspergillosis
This indication commissioned by NHS England.
http://formulary.panmerseyapc.nhs.uk/chaptersSub.asp?FormularySectionID=5


Shared Care

PURPLE DMD Shared Care Frameworks
Clarification of the monitoring recommendations. Link to methotrexate SCF is provided as an example.
https://www.panmerseyapc.nhs.uk/media/2109/azathioprine_sharedcare.pdf
https://www.panmerseyapc.nhs.uk/media/2110/ciclosporin_sharedcare.pdf
https://www.panmerseyapc.nhs.uk/media/2111/leflunomide_sharedcare.pdf
https://www.panmerseyapc.nhs.uk/media/2112/mercaptopurine_sharedcare.pdf
https://www.panmerseyapc.nhs.uk/media/2068/methotrexate_sharedcare.pdf
https://www.panmerseyapc.nhs.uk/media/2114/mycophenolate_sharedcare.pdf
https://www.panmerseyapc.nhs.uk/media/2113/penicillamine_sharedcare.pdf
https://www.panmerseyapc.nhs.uk/media/2115/sodiumaurothiomalate_sharedcare.pdf
https://www.panmerseyapc.nhs.uk/media/2116/sulfasalazine_sharedcare.pdf


Prescribing Support Information

AMBER INITIATED Dementia
Updated document at routine review-by-date – minimal changes to reflect new NICE guidance (NG97). 
https://www.panmerseyapc.nhs.uk/media/2091/dementia.pdf


Antimicrobial Prescribing 

Genital tract infections
Chalmydia update
http://formulary.panmerseyapc.nhs.uk/chaptersSubDetails.asp?FormularySectionID=27&SubSectionRef=27.11&SubSectionID=A100&drugmatch=5571#5571


Fungal infections
http://formulary.panmerseyapc.nhs.uk/chaptersSubDetails.asp?FormularySectionID=27&SubSectionRef=27.13&SubSectionID=A100

Miscellany
Treatment of Splenectomy Patients
http://formulary.panmerseyapc.nhs.uk/chaptersSubDetails.asp?FormularySectionID=27&SubSectionRef=27.14&SubSectionID=A100v
Outpatient Parenteral Antimicrobial Therapy (OPAT)
http://formulary.panmerseyapc.nhs.uk/chaptersSubDetails.asp?FormularySectionID=27&SubSectionRef=27.15&SubSectionID=A100
Antimicrobial Prophylaxis: Endocarditis and Malaria
http://formulary.panmerseyapc.nhs.uk/chaptersSubDetails.asp?FormularySectionID=27&SubSectionRef=27.17&SubSectionID=A100
Current statutorily notifiable diseases and food poisoning (2017) http://formulary.panmerseyapc.nhs.uk/chaptersSubDetails.asp?FormularySectionID=27&SubSectionRef=27.18&SubSectionID=A100
List of Contributors
http://formulary.panmerseyapc.nhs.uk/chaptersSubDetails.asp?FormularySectionID=27&SubSectionRef=27.19&SubSectionID=A100
Useful Contact Numbers
http://formulary.panmerseyapc.nhs.uk/chaptersSubDetails.asp?FormularySectionID=27&SubSectionRef=27.20&SubSectionID=A100

Safety Updates

November

Please click here for a summary of  safety updates and SPC updates in November.

Hydrochlorothiazide: risk of non-melanoma skin cancer, particularly in long-term use
https://www.gov.uk/drug-safety-update/hydrochlorothiazide-risk-of-non-melanoma-skin-cancer-particularly-in-long-term-use

Systemic and inhaled fluoroquinolones: small increased risk of aortic aneurysm and dissection; advice for prescribing in high-risk patients
https://www.gov.uk/drug-safety-update/systemic-and-inhaled-fluoroquinolones-small-increased-risk-of-aortic-aneurysm-and-dissection-advice-for-prescribing-in-high-risk-patients


European CHMP endorses suspension or restrictions of quinolone and fluoroquinolone antibiotics due to disabling and potentially permanent adverse effects
https://www.ema.europa.eu/documents/referral/quinolone-fluoroquinolone-article-31-referral-disabling-potentially-permanent-side-effects-lead_en.pdf

Cannabidiol oil – potential adverse effects and drug interactions
https://www.sps.nhs.uk/articles/cannabidiol-oil-potential-adverse-effects-and-drug-interactions/

Nutilis Clear Product Update – New Scoop and Mixing Instructions
https://psnc.org.uk/our-news/nutilis-clear-product-update-new-scoop-and-mixing-instructions/



December

Please click here for a summary of  safety updates and SPC updates in December.

In use product safety assessment report for enoxaparin biosimilars (INHIXA and AROVI)
https://www.sps.nhs.uk/articles/in-use-product-safety-assessment-report-for-inhixa-enoxaparin-biosimilar/

Emollients: new information about risk of severe and fatal burns with paraffin-containing and paraffin-free emollients
https://www.gov.uk/drug-safety-update/emollients-new-information-about-risk-of-severe-and-fatal-burns-with-paraffin-containing-and-paraffin-free-emollients

Hydrocortisone muco-adhesive buccal tablets: should not be used off-label for adrenal insufficiency in children due to serious risks
https://www.gov.uk/drug-safety-update/hydrocortisone-muco-adhesive-buccal-tablets-should-not-be-used-off-label-for-adrenal-insufficiency-in-children-due-to-serious-risks

Valproate medicines: are you in acting in compliance with the pregnancy prevention measures?
https://www.gov.uk/drug-safety-update/valproate-medicines-are-you-in-acting-in-compliance-with-the-pregnancy-prevention-measures

Herbal skin cream found to contain steroids
https://www.gov.uk/government/news/herbal-skin-cream-found-to-contain-steroids

What information is available on drugs in diving?
https://www.sps.nhs.uk/articles/what-information-is-available-on-drugs-in-diving/

What is the first choice antidepressant for patients with renal impairment?
https://www.sps.nhs.uk/articles/what-is-the-first-choice-antidepressant-for-patients-with-renal-impairment/

What is the risk of interaction between opioids and monoamine oxidase inhibitors (MAOIs)?
https://www.sps.nhs.uk/articles/what-is-the-risk-of-interaction-between-opioids-and-monoamine-oxidase-inhibitors-maois/

Which opioids can be used in renal impairment?
https://www.sps.nhs.uk/articles/which-opioids-can-be-used-in-renal-impairment/

Prescribing News

NICE Guidance November 2018 

There have been two guidelines published in November 2018 by the National Institute for Clinical Excellence which has impact upon primary care.

The Heavy menstrual bleeding guideline has been updated. The guideline was updated to reinstate recommendations on ulipristal acetate (Esmya®) in line with the European Medicines Agency review. 

The Urinary tract infection (catheter-associated): antimicrobial prescribing guideline has been published. The guideline sets out an antimicrobial prescribing strategy for catheter-associated urinary tract infection in children, young people and adults. 

The following below guidelines have also been released and they aim to provide an antimicrobial prescribing strategy to optimise antibiotic use and reduce antibiotic resistance.
Clinicians should be aware of these guidelines and implement any necessary changes to their practice. 

CKS Updates November 2018 

During the month of November 2018, the following Clinical Knowledge Summaries were updated:
 
There have been minor restructures to the topics listed above. Clinicians can use the updated and new information when reviewing patients.


NICE Guidance December 2018

There have been five guidelines published in December 2018 by the National Institute for Clinical Excellence which has impact upon primary care.

The Antenatal care for uncomplicated pregnancies guideline has been updated. A link to the UK CMO’s low risk-drinking guideline has replaced the existing recommendations on alcohol consumption in pregnancy.

The Post-traumatic stress disorder guideline has been published and replaces previous guidance from 2005.  The guidance sets out recognising, assessing and treating post-traumatic stress disorder (PTSD) in children, young people and adults. 

The Chronic obstructive pulmonary disease in over 16s guideline replaces guidance from June 2010. The guideline sets out diagnosing and managing chronic obstructive pulmonary disease (COPD) in people aged 16 and older, which includes emphysema and chronic bronchitis. 

The Chronic obstructive pulmonary disease (acute exacerbation): antimicrobial prescribing guideline has been published. The guideline sets out an antimicrobial prescribing strategy for acute exacerbations of COPD. 

The Bronchiectasis (non-cystic fibrosis), acute exacerbation: antimicrobial prescribing guideline has been published. The guideline sets out an antimicrobial prescribing strategy for managing and preventing acute exacerbations of bronchiectasis (non-cystic fibrosis). 

Clinicians should be aware of these guidelines and implement any necessary changes to their practice. 
 
CKS Updates December 2018

There were no CKS updates during the month of December 2018.
 
Useful Resources

New online resource available for adults with Type 1 diabetes 
The NHS diabetes programme have developed new content which is accessible on the NHS UK website. This has been developed in collaboration with its partners Diabetes UK and NHS Digital. Further information on how the content can be utilised has been relayed in a letter from Dr Partha Kar, NHS England Deputy Clinical Director Diabetes.

Acute Kidney Injury (AKI) 
Resources to support the NHS campaign to improve the care of people at risk of, or with, Acute Kidney Injury can be accessed via the Think Kidneys website.

Practices should ensure patients at risk of AKI are identified and medication reviews are carried out. Advice should be given on measures to help prevent AKI and actions to be taken if they are unwell. 

BNF App drug interactions checker
The BNF App is a free drug interaction checker which can be downloaded free of charge on smart phones and tablets via this link. This app should be utilised by all prescribers particularly when prescribing outwith the support of a prescribing support software e.g. during clinical system failure, home visit. 

TARGET Antibiotics -Prescribing in Primary Care online CPD course 
A new free to access online CPD course starting 28 January 2019 has been produced in collaboration between the British Society of Antimicorbial Chemotherapy and TARGET. The course is aimed at primary care healthcare professionals who are involved in the treatent of common infections. Topics will be released every week for 7 weeks, including:
  • Introduction to Antimicrobial Resistance in Primary Care
  • Prescribing in Urinary Tract Infections
  • Assessing the Need for Antibiotics
  • Managing Patient Expectations and Back up/Delayed Prescribing
  • Antibiotics for Children
  • Common Practice Approach

Drug Availability

Products in short supply and product discontinuations

The following links provide prescribers with up to date information on commonly prescribed products which are currently in short supply from the manufacturers.
 
The information held on these lists is not exhaustive. Availability can vary geographically and also between wholesalers. Up-to-date information should be sought from manufacturers, local community pharmacies and suppliers.

Supply issues update for primary care December 2018 / January 2019

Due to a quality issue with the most recent batch of Clexane 40mg injection it is anticipated that there will be supply issues affecting Clexane 40mg injection until the week commencing 18th February 2019. This date may be brought forward to the end of January/early February if the current batch passes further QA testing.
 
 
Ongoing Issues 

Drug Tariff Changes

This summary document shows the top 10 price changes since last month, the top 25 changes compared to three months ago, and the top 50 since last year.
 
Tell me more about drug tariff price changes.

Antimicrobial Updates

Please click here for a full summary of antimicrobial related guidelines and SPC updates in December

Chronic obstructive pulmonary disease (acute exacerbation): antimicrobial prescribing- guidance (NG114)
https://www.nice.org.uk/guidance/ng114

Bronchiectasis (non-cystic fibrosis), acute exacerbation: antimicrobial prescribing- guidance (NG117)
https://www.nice.org.uk/guidance/ng117

Relationship between prescribing of antibiotics and other medicines in primary care: a cross-sectional study
https://bjgp.org/content/early/2018/12/14/bjgp18X700457

A case report of photodermatoses induced by the antifungal drug terbinafine
https://ejhp.bmj.com/content/early/2018/12/16/ejhpharm-2018-001683

Notification of the discontinuation of Zovirax (aciclovir) eye ointment 3% 4.5g
https://gskpro.com/en-gb/products/zovirax/

Association of a label of penicillin allergy with increased risk of MRSA and Clostridium difficile infection: DTB Select summary
https://dtb.bmj.com/content/57/1/4

Challenging the supremacy of intravenous antibiotics
https://dtb.bmj.com/content/57/1/2

Public Health England investigates rise in reports of acute flaccid paralysis
https://www.gov.uk/government/news/phe-investigating-rise-in-reports-of-rare-illness

NICE Bites: Prostatitis
https://www.sps.nhs.uk/articles/nice-bites-prostatitis/
Please note that the information in this newsletter is correct at the time of publication.
Clinicians should always refer to the most up to date information.


Contacts
Kieron Donlon: kieron.donlon1@nhs.net - 0151 296 7076


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