It’s incredible that we find any medicines that work in the human body at all, given that we're the incredibly complex product of billions of years of evolution. Yet as we move from small molecules to large molecules to other modalities for making medicines -- and as technology comes in -- more is possible than ever before. From the evolution of the field of synthetic biology and the science (and business) of making medicines, to managing data and training doctors, this special healthcare series covers it all:

• listen to this conversation on pipelines of innovation (with Novartis CEO Vas Narasimhan)
• listen to this conversation on data network effects and building a bio company (with Chief Medical and Chief Scientific Officer Amy Abernethy)
• listen to this conversation on 'dark data' in healthcare (with former CTO of the U.S. Department of Health and Human Services Susannah Fox)
• listen to this conversation on synthetic biology (with field pioneer and MIT bioengineering professor James Collins)
• read this article on why we need more "physician innovators" (with the CEO of the American Medical Association) 
• read this tweetstorm for bio entrepreneurs, on the importance of selecting disease areas

The most successful companies and products of the internet era have all been predicated on the concept of network effects, but lately, reality seems to be diverging from theory. Does that mean network effects as we know them are dead? No! But in practice, they are more dynamic than ever -- evolving as product, users, competition, and even regulations change. So how do we know what we don't know, and what are the next opportunities here?

• read this post on the dynamics of network effects in practice
• check out this list of 16 ways to measure network effects
• read this post and watch this video on what's next for marketplace startups (hint: managed marketplaces, services, and more)

"Crossing the chasm" is a useful model for thinking about going from early adopters to majority use, but for many enterprise startups, the model doesn't always play out as founders expect. There's a lot of nuance to applying it in practice -- especially given the fast pace of innovation today and secular shifts such as open source, cloud, and bottom-up services. So how should founders think about all this, particularly when it comes to geographic expansion, incumbents, and more? 

• read this post on "the unending chasm", and how to survive it
• read this reply by Geoffrey Moore
• read this response to the response

Technologies -- from smartphones to cloud to video to the internet -- usually arrive in pairs: a "strong" form and a "weak" form. Strong technologies adapt the world to themselves, building from first principles; weak technologies, on the other hand, adapt to the world as it currently exists. Yet strong technologies are the ones that define new eras, and progress... Speaking of: As open source has grown in importance, who will control the software that powers the next generation of the internet? 

• read this post on strong and weak technologies
• read this article on how blockchains and cryptocurrencies can do for cloud-based services what open source did for software

Every year, CES puts the latest and greatest developments in consumer technology on display in Vegas. But beyond the excitement and the hype, what’s really here (or not here) to stay when it comes to the smart, connected home and voice interfaces? What's our pulse-check on the broader tech trends at play? And then, how should we think about the broader surface area for attacks... and other key trends for security in 2019?

• listen to this podcast on consumer tech trends beyond CES 2019
• read this show report post-CES 2019
• read this post on 5G and "a fatter pipe"
• read this roundup of notes on security in 2019 
• watch this video on what's new for security startups