News and Updates from CAAT
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Contents:
CAAT Satellite Meeting at Society of Toxicology (SOT)
Updates on Activities Related to 21st Century Toxicology: Invited Presentations and Open Microphone
A Society of Toxicology (SOT) Satellite Meeting
Organized by CAAT and the Human Toxicology Project Consortium (HTPC)
Thursday, March 14, 2019
12:30-4pm
Hilton Hotel
Baltimore, MD
If you’re planning to attend the Society of Toxicology conference in Baltimore this March, please join CAAT and the Human Toxicology Project Consortium (HTPC) for our annual satellite meeting on advancing 21st century toxicology activities. The satellite meeting provides an informal setting in which interested stakeholders can update each other on this important topic.
The meeting will feature a number of invited presentations but also leave time for an open microphone segment in which participants are welcome to make announcements or to comment on germane topics, with or without a few slides.
The preliminary program is as follows:
12:30 Box lunch (for pre-registered participants) and welcome, Martin Stephens (Johns Hopkins University)
13:00 Invited updates (10-minute talks each followed by up to 5 minutes of discussion)
- ToxCast - Russell Thomas (EPA)
- Tox21 - Rick Paules (NIEHS)
- EU Tox-Risk - Bob van de Water (Leiden University)
- ICCVAM - Nicole Kleinstreuer (NICEATM)
- Organ-on-a-chip & Predictive Toxicology Roadmap - Suzanne Fitzpatrick (FDA)
- Progress in implementing NAMs under TSCA - Gino Scarano (EPA)
- Canadian Centre for Alternatives to Animal Methods - Charu Chandrasekera (University of Windsor)
- Evidence-based data analytics predict human DILI using ToxCast data - Katya Tsaioun (Johns Hopkins)
- Human Toxicology Project Consortium - Catherine Willett (Humane Society Int’l)
- CAAT’s In Silico Prediction Tool - Thomas Hartung (Johns Hopkins)
15:30 Open microphone for comments, announcements, and discussion
16:00 Adjourn
Please email Camila Januario to register. Box lunches will be available to those who have pre-registered.
Details
CAAT/EU-ToxRisk Symposium at SOT: Strategic Development of Read-Across within the EU-ToxRisk Project and Beyond
March 11, 2019
1:45-4:30pm
CC Room 316
EU-ToxRisk will attend the SOT 58th Annual Meeting and ToxExpo 2019 in Baltimore. You can find us at booth #2216 and join the scientific session “Strategic Development of Read-Across within the EU-ToxRisk Project and Beyond” (March 11, 1:45pm-4:30pm, CC Room 316,).
In this symposium, we will provide a view across the Atlantic—an in-depth overview and demonstrate opportunities of the use of read-across, starting with an EU regulatory perspective and then broadening the scope to the most up-to-date developments from the EU-ToxRisk program. A focus is set on read-across case studies, by which the use of NAMs and mechanistic data is demonstrated. While the majority of techniques used within EU-ToxRisk are already well established, the project also invested into the development of new in silico prediction models. In addition, the symposium will address automated read-across (RASAR – read-across-based structure activity relationships) and Good Read-Across Practices. We believe that lessons from the reported proof of concept read-across approaches will help to develop new mechanism-based chemical safety testing strategies.
Details
New Frontiers in 3D Conference
April 25, 2019
Cambridge, MA
Co-Sponsored by CAAT
This conference, following the success of its 2016 Baltimore premier, is an exclusive one-day scientific meeting to discuss practical applications for emerging 3D cell technologies for human disease modeling and predictive drug safety testing.
CAAT Director Thomas Hartung will give a presentation on A World Without Animal Testing: the Future of 3D.
Call for Abstracts: Registrants are invited to submit an abstract for poster presentations. Abstracts received on or before March 25 will be considered for a podium presentation. Decisions will be communicated by email by April 15, 2019. Please note that there is no fee for abstract submissions, but you must be registered to present. All presenters are responsible for their own expenses including, but not limited to, transportation, accommodation, parking, meals (not included with conference registration), and registration fees.
Full Details and Registration
Latest Newsletter from the Evidence-based Toxicology Collaboration (EBTC)
The latest newsletter details EBTC involvement at SOT 2019, US NAS workshops update, new publications from the collaboration, and more.
EBTC Newsletter February 2019
Helena Hogberg Receives Colgate-Palmolive Grant for Alternative Research
CAAT Deputy Director Helena Hogberg received the Colgate-Palmolive Grant for Alternative Research for her project entitled: Myelination as an Endpoint for Developmental Neurotoxicity (DNT) Testing in a Human 3D In Vitro Model.
Full Listing of Awardees
2nd Open EU-ToxRisk Symposium
The 2nd Open EU-ToxRisk Symposium (12-13 Feb. 2019) and 5th EU-ToxRisk General Assembly (12-14 Feb. 2019) took place in Egmond aan Zee, The Netherlands, at the Hotel Zuiderduin. The Open EU-ToxRisk Symposium (Feb. 12-13), a public event and open to all interested industry and regulatory stakeholders, provided insight into the lessons from EU-ToxRisk read-across case studies and in the new EU-ToxRisk case studies for the second half of the project. Both events promoted the interaction between the project partners and the participants stakeholders.
The external participants also received insight in the scientific progress of development and application of new approach methods for chemical safety assessment, as well as in opportunities for joint case studies with EU-ToxRisk consortium.
Human-based Technologies Symposium
March 14, 2019
Bari, Italy
The first event on human-based technologies hosted by the University of Bari in the South of Italy will take place next 14th March 14th. The symposium will spotlight innovation in biomedical research with human based technologies. Participation is free upon registration and open to all scientists working in the area of veterinary science and biotechnologies. Invited speakers will talk about the interactions between advances new technologies and legislation in the area of biomedical sciences and microphysiological systems.
Costanza Rovida from CAAT-Europe will speak about the application of non animal methods for regulatory purposes. Full program and registration are available here. Official language is Italian.
Save the Date!
6th Symposium on Social Housing of Laboratory Animals
June 3-4, 2019
Beltsville, MD
In collaboration with USDA Animal Welfare Information Center, NIH Office of Laboratory Animal Welfare, and the Johns Hopkins Department of Molecular and Comparative Pathobiology
Preliminary Program
A Night of Tasty Tacos and Truly Toxic Trivia
March 9th, 7pm
Pratt Street Ale House
Baltimore
Free Admission! Free Taco Bar and Soft Drinks!
Cash Bar and Craft Beer! Prizes for the Winning Teams!
Join us for a night of short talks on toxicological topics and trivia and learn how the science of toxicology affects your community.
Speakers include: Thomas Hartung (CAAT), Phil Wexler and Sara Humes (Toxicology Education Foundation), Melissa McDiarmid (University of Maryland School of Medicine), Keeve Nachman (JHU Center for a Livable Future), and Bruce Anderson (Maryland Poison Center)
Toxathon 2019 sponsored by the Johns Hopkins Center for Alternatives to Animal Testing (CAAT) and the Toxicology Education Foundation
Registration
EU-ToxRisk February Newsletter
The latest EU-ToxRisk newsletter (February 2019) is available online here (PDF). It contains highlights on the technological and toxicological expertise of the EU-ToxRisk Case Studies, the dedicated approach for the development of a guidance document for NAM-based read-across, as well as an overview on the established methods and their integration in the 1st EU-ToxRisk industry-joint case studies.
Society for Alternatives to Animal Experiments (SAAE) Launches in India
In November 2018, India joined other innovative economies working to replace the use of animals in laboratory experiments with the launch of the Society for Alternatives to Animal Experiments (SAAE) during the country’s second national conference on alternatives in New Delhi. Humane Society International, founder of the BioMed21 Collaboration, was a lead sponsor and keynote speaker at the conference, which created a platform for national and international scientists from various backgrounds to engage in discussions pertaining to the present and future of alternatives to the use of animals in research and testing.
Research Associate Andre Kleensang represented CAAT at the conference.
Details and Registration: https://theactc.com
The CAAT Team
 
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