June 12, 2019 @ McMaster University, Hamilton, Ontario, Canada
Application of evidence-based methods to construct mechanistic frameworks for the development and use of non-animal toxicity tests
Register here: https://www.eventbrite.com/e/ebtc-mechanistic-evidence-pre-meeting-grade-tickets-57992030725
Background
Systematic evidence synthesis methods and adverse outcome pathways are two relatively recent arrivals in the toxicologist's toolbox, which promise to bring toxicological research into the 21st Century.
Objectives
The goal of this workshop is to explore, via discussion of four related themes, how systematic review methods and AOP concepts can be combined to develop and use non-animal test methods for predicting the toxicity of chemical substances in an evidence-based manner.
1. How do we distinguish high quality in vitro studies from low quality ones?
2. What does a systematic approach to AOP development look like?
3. How does one distinguish spurious AOPs from plausible ones?
4. How can one use AOP information to develop non-animal toxicity assays?
Important note
Registration for this meeting is free and open to everyone; however, due to limited seating the organizing committee will have to make a final decision on participation depending on demand and the scientific objectives of the workshop. Please do not make any travel arrangements until you receive an official email confirming your attendance.
Agenda
9:00 - Introduction (EBTC, GRADE - Katya Tsaioun, Holger Schünneman)
9:15 - Keynote talks (30 minutes: 25 min. presentation + 5 min. clarifying questions):
- Systematic maps and literature-driven AOP development :: Dr Michelle Angrish, US EPA IRIS program
- Certainty in AOPs and AOP-based alternatives :: Prof Holger Schünemann, Chair and Professor, Department of Health Research Methods, Evidence, and Impact; Director, Cochrane Canada and McMaster GRADE Centre
10.15-10.45 am COFFEE BREAK
- Risk of bias appraisal of in vitro studies :: Dr Andrew Rooney, NIEHS, National Toxicology Program, OHAT
- Using AOPs to develop non-animal alternatives and IATAs :: Dr Patience Browne, OECD
11.45-12.00 Explanation of how break-out sessions will be run
12.00 - 1 pm LUNCH
Afternoon: Break-out sessions (2 hours):
- Quality appraisal of individual in vitro studies (RoB domains, impact of role within risk assessment etc). Moderators: Andrew Rooney & Elisa Aiassa; Rapporteur - Rob de Vries (EBTC)
- Systematic maps and literature-driven AOP development. Moderators: Michelle Angrish & TBD; Rapporteur - Paul Whaley (EBTC)
- Certainty in AOPs and AOP-based alternatives. Moderator Rebecca Morgan & TBD; Rapporteur - Sebastian Hoffmann (EBTC)
- Using AOPs to develop alternatives and IATAs. Patience Browne, OECD; Rapporteur - Katya Tsaioun (EBTC)
3.00 pm TEA BREAK
3.15 pm Report from the break-out groups
5:00 pm Follow-up and actions from the day.
|
