News and Updates from CAAT
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Contents:
NEW ALTEX: Issue 2, 2019
The latest issue of ALTEX: Alternatives to Animal Experimentation is now online in its entirety. The issue includes:
- Addressing potential ethical issues regarding the supply of human-derived products or reagents in in vitro OECD Test Guidelines
Miriam N. Jacobs, Rosemary J. Versteegen, Carol Treasure, Jennifer Murray
- Non-animal models in dermatological research
Elena Dellambra, Teresa Odorisio, Daniela D'Arcangelo, Cristina Maria Failla, Antonio Facchiano
- Detection and profiling of diarrheic marine biotoxins in shellfish by mRNA analysis of exposed Caco-2 cells using qRT-PCR and multiplex magnetic bead-based assays
Marcia Bodero, Toine F. H. Bovee, Liza Portier, Peter J. M. Hendriksen
- Prioritizing substances of genotoxic concern for in-depth safety evaluation using non-animal approaches: The example of food contact materials
Melissa Van Bossuyt, Els Van Hoeck, Tamara Vanhaecke, Vera Rogiers, Birgit Mertens
- Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells
Stefanie Hofer, Marlies Stonig, Verena Wally, Anja Hartmann, Dietmar Fuchs, Martin Hermann, Martin Paparella, Markus Ganzera, Johanna M. Gostner
- Prenatal developmental toxicity testing of petroleum substances using the zebrafish embryotoxicity test
Lenny Kamelia, Sylvia Brugman, Laura de Haan, Hans B. Ketelslegers, Ivonne M. C. M. Rietjens, Peter J. Boogaard
And much more!
Full text: ALTEX: Alternatives to Animal Experimentation Volume 36, No. 2
CAAT Grants: Call for Preproposals
Deadline: May 5, 2019
The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) is soliciting projects that focus on the implementation of the NAS Report: Toxicity Testing in the 21st Century: A Vision and a Strategy in the following areas:
- Proposals Relating to Toxicology: Maximum grant amount is $40,000. The objective should be to significantly reduce or replace laboratory animals. Examples of acceptable projects could include: providing mechanistic understanding of in vitro responses to toxicants in human cells, development of AOPs, or conducting systematic reviews. Consideration should be given to the translation of this new method to evaluate/predict health outcomes.
CAAT VISION
- To be the leading force in the development and use of reduction, refinement, and replacement alternatives* in research, testing, and education to protect and enhance the health of the public.
CAAT MISSION
- Promote and support research in the development of in vitro and other alternative techniques.
- Serve as a forum to foster discussion among diverse groups leading to creative approaches to facilitate acceptance and implementation of alternatives.
- Provide reliable information on the science, philosophy, and public policy of alternatives to academia, government, industry, and the general public.
- Educate and train in the application of alternatives.
*Alternatives are defined as new methods that refine existing tests by minimizing animal pain or distress, reduce animal usage, or replace whole animal tests.
To submit, please use the Preproposal Form. Full details here.
Next Generation Humane Science Award: DEADLINE APRIL 14TH
This award is available annually to young scientists to acknowledge and encourage researchers who focus on replacing animal experiments. The 2019 award will provide a prize of up to $9,000 recognizing the work of one young scientist, or may be shared among two or more young scientists.
Complete Information and Registration
New Frontiers in 3D Conference
April 25, 2019
Cambridge, MA
Co-Sponsored by CAAT
This conference, following the success of its 2016 Baltimore premier, is an exclusive one-day scientific meeting to discuss practical applications for emerging 3D cell technologies for human disease modeling and predictive drug safety testing.
CAAT will give a presentation on A World Without Animal Testing: the Future of 3D.
Call for Abstracts: Registrants are invited to submit an abstract for poster presentations. Abstracts received on or before March 25 will be considered for a podium presentation. Decisions will be communicated by email by April 15, 2019. Please note that there is no fee for abstract submissions, but you must be registered to present. All presenters are responsible for their own expenses including, but not limited to, transportation, accommodation, parking, meals (not included with conference registration), and registration fees.
Full Details and Registration
Upcoming: CAAT-Europe Information Day On Biology-inspired Microphysiological Systems (MPS) to Advance Medicines for Patients' Benefit
June 17, 2019
Berlin, Germany
Co-organized with the Centre for Entrepreneurship (CfE) of the Technische Universität Berlin
The Information day on “Biology-inspired Microphysiological Systems (MPS) to Advance Medicines for Patients' Benefits” will host key international experts from academia, regulatory agencies, and industry.
Microfluidic microphysiological systems (also referred to as tissues-on-a-chip, organ-on-a-chip, multi-organ-chip, human-on-a-chip, body-on-a-chip, or patient-on-a-chip tools) are considered an enabling technology for the development of approaches to reliably predict the safety and efficacy of novel drug candidates prior to their use in humans. A transatlantic toxicology think tank involving academia, industries, and regulatory bodies from all over the world reviewed the status quo of MPS in June 2015 in Berlin (Marx et al 2016, ALTEX 33,272-321). Now, four years later, stakeholders will meet again in Berlin to update the review and to examine the roadmap for the reduction and replacement of animals by MPS tools for precision benefits for patients.
Full Details
EU-ToxRisk workshop: New Approach Method (NAM)-supported Read-across: from Case Studies to Regulatory Guidance in Safety Assessment
May 21-22, 2019
Espoo, Finland
Co-organized with ECHA, EFSA, NTP, EPA, OECD, and SCCS
The workshop is open to experts with interest and background into regulatory science coming from agencies, industry, and academia, providing an exceptional forum for discussion about the regulatory aspects of NAM-supported read-across. The meeting will focus on several scientifically advanced project case studies developed within the EU-ToxRisk project, the OECD/IATA program, and NIHS Japan and it will cover different regulatory contexts—both European (e.g. REACH, EU Pesticides) and global (Canada Chemicals Management Plan and Japanese Chemical Substances of Control Law).
The workshop outcomes will be included in an improved regulatory guidance document for NAM-supported read-across which EU-ToxRisk team plans to disseminate for the toxicological community. This will improve the quality of the submission of real read-across cases by registrants, and eventually increase the success rate of non-animal safety approaches.
We would be happy to welcome you to this event and bring together the most relevant specialists in this field. If you are interested, please contact the organizers via email at caat-eu-2@uni-konstanz.de and you will receive all the details for the workshop website. Registration deadline is Thu 25 April 2019.
Agenda and Registration
The EU-ToxRisk project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement number 681002.
Registration Open!
6th Symposium on Social Housing of Laboratory Animals
June 3-4, 2019
Beltsville, MD
In collaboration with USDA Animal Welfare Information Center, NIH Office of Laboratory Animal Welfare, and the Johns Hopkins Department of Molecular and Comparative Pathobiology
Program and Registration
Costanza Rovida at Chemical Watch Biocides Symposium
May 24, 2019
Rome
CAAT-Europe's Costanza Rovida will discuss "Application of New Approach Methodologies (NAMs) in the definition of endocrine disruptor properties of biocide substances" during the breakout session on ED criteria at the upcoming Chemical Watch Symposium in Rome. Details here.
Save the Date!
5th International Conference on Alternatives for Developmental Neurotoxicity (DNT) Testing
February 3-5, 2020
Konstanz, Germany
The effects of chemical exposure on the susceptible developing human nervous system can cause severe lasting neurological deficits.
This conference will bring together diverse stakeholders from around the globe, including research scientists, regulators, industry representatives, academics, and pediatricians to discuss the actions to take for:
- improving the development of time- efficient and human-relevant predictive in vitro DNT methods, and;
- boosting their use in the risk assessment regulatory decision-making process.
More information will be soon available in an upcoming CAATwalk newsletter.
CellTox 2019
May 7, 2019
Milano, Italy
Details (PDF)
Society for In Vitro Biology Annual Meeting
June 8-12, 2019
Tampa, Florida
Details
Best wishes from all of us,
The CAAT Team
 
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