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Researchers studying how human food scraps contribute to diseases in ecosystems

Monica Ponder, a professor of food science and technology in the College of Agriculture and Life Sciences, and Kathleen Alexander, a professor in the Department of Fisheries and Wildlife in the College of Natural Resources and Environment, are studying the impact of bacteria from human food scraps that travel through ecosystems in both Botswana and the United States. These bacteria are often associated with fruits, vegetables, and raw or undercooked meats and can spread through the ecosystem from scraps being fed to companion animals or livestock.

These food scraps also get consumed by wildlife, providing another avenue for transmission and method for disease to establish itself in a wildlife population before spreading further.  

Campylobacter may also be a leading cause of diarrheal illness in Botswana, and recent collaborations of the Alexander and Ponder labs have shown that wildlife may also harbor Campylobacter. Wildlife often venture into the landfill sites and scavenge for food, rummaging through the garbage before returning to the wilderness.

The National Science Foundation funded the research project with $1.2 million in funding over two years particularly because of the focus on understanding how antibiotic resistance moves through the systems in the two countries with varied public antibiotic access and differences in land use.  READ MORE>>

Virginia Tech researchers find potential roadmap to removing mosquitoes' ability transmit malaria

Researchers in the College of Agriculture and Life Sciences at Virginia Tech have found unique interactions in the cells of five mosquito species that could be a roadmap to removing the ability to transmit malaria and other diseases in the future. The findings were recently published in Nature Communications.

People often use insecticides to spray as much as possible to kill mosquitoes. But this form of control doesn’t discriminate between good and bad insects and also builds resistance among mosquitoes and insects that survive through natural selection and mutations.

After years of relative success controlling mosquito populations in this manner, it is now being reevaluated due to a significantly decreasing effectiveness and not being ecologically friendly.

“We have to constantly invent new insecticides,” said Igor Sharakhov, one of the researchers on the project, a professor of entomology and an affiliated faculty with the Fralin Life Sciences Institute and CeZAP. “With genomic approaches showing more promise, we can generate so-called gene drives and create a construct that could either suppress the mosquito population or render it incapable of transmitting disease.”  READ MORE>>

Mohamed Seleem named director of the Center for One Health Research

Mohamed Seleem,  the Tyler J. and Frances F. Young Chair in Bacteriology at the Virginia-Maryland College of Veterinary Medicine, has been named director of the Center for One Health Research.

The Center for One Health Research (COHR) is a collaboration between the veterinary college and the Edward Via College of Osteopathic Medicine, both of which have interest in cooperative research and scholarship related to infectious diseases.  

Both colleges follow the One Health philosophy — the concept that animal health, human health, and the environment are closely linked, requiring professionals in these fields to collaborate to improve overall health. READ MORE>>

CeZAP 2022 Interdisciplinary Team-building Pilot Grant
CeZAP announces Request for Application (RFP) for the 2022 Interdisciplinary team-building pilot grant. The 2021 CeZAP Pilot Grant program is once again supported financially by Fralin Life Sciences Institute and the Virginia Agricultural Experiment Station, and we appreciate their continuous support!

The deadline for applications is August 26, 2022
2022 CeZAP Interdisciplinary Team-building Pilot Grant RFP

Save the date
2022  CeZAP Infectious Diseases Symposium 

October 7, 2022 
8:30 am - 5:30 pm

The Inn at Virginia Tech


Keynote speakers include: 

 Jennifer McQuiston
Deputy Director, Division of High Consequence Pathogens and Pathology
Centers for Disease Control and Prevention


T. Jake Liang
NIH Distinguished Investigator and Member of National Academy of Medicine, NIH

Sue VandeWoude
Director of One Health Institute and Member of National Academy of Sciences, Colorado State University

Congratulations to the following CeZAP Affiliated Faculty Members on receiving the following promotions:

Promotion to associate professor with tenure 

  • Lauren Childs, mathematics
  • Rebecca Hester, science, technology, and society

Promotion to professor

  • Zhaomin Yang, biological sciences

Leigh-Anne Krometis was recenlty awarded The Universities Council on Water Resources (UCOWR) 
Mid Career award for Applied Water Research 

Recent Publications by CeZAP Affiliated Faculty
EGR1 Upregulation during Encephalitic Viral Infections Contributes to Inflammation and Cell Death Lehman C, Smith A, Kelly J, Jacobs JL, Dinman JD, Kehn-Hall K. Viruses  DOI: 10.3390/v14061210

Genome size distributions in bacteria and archaea are strongly linked to evolutionary history at broad phylogenetic scales Martinez-Gutierrez CA, Aylward FO. PLoS Genet  DOI: 10.1371/journal.pgen.1010220

Sarcoptic mange: An emerging panzootic in wildlife Escobar LE, Carver S, Cross PC, Rossi L, Almberg ES, Yabsley MJ, Niedringhaus KD, Van Wick P, Dominguez-Villegas E, Gakuya F, Xie Y, Angelone S, Gortázar C, Astorga F. Transbound Emerg Dis 
DOI: 10.1111/tbed.14082

Relating Eulerian and Lagrangian spatial models for vector-host disease dynamics through a fundamental matrix  Bernal E, Saucedo O, Tien J. J Math Biol  
DOI: 10.1007/s00285-022-01761-z

Integrating Environmental Dimensions of "One Health" to Combat Antimicrobial Resistance: Essential Research NeedsJin L, Pruden A, Boehm AB, Alvarez PJJ, Raskin L, Kohn T, Li X. Environ Sci Technol DOI: 10.1021/acs.est.2c01651

Investigating plant disease outbreaks with long-read metagenomics: sensitive detection and highly resolved phylogenetic reconstruction applied to Xylella fastidiosa. Johnson MA, Liu H, Bush E, Sharma P, Yang S, Mazloom R, Heath LS, Nita M, Li S, Vinatzer BA .Microb Genom
DOI: 10.1099/mgen.0.000822

Stress Hormones Epinephrine and Corticosterone Selectively Reactivate HSV-1 and HSV-2 in Sympathetic and Sensory Neurons Goswami P, Ives AM, Abbott ARN, Bertke AS.  Viruses 
DOI: 10.3390/v14051115

Behavioral and postural analyses establish sleep-like states for mosquitoes that can impact host landing and blood feedingAjayi OM, Marlman JM, Gleitz LA, Smith ES, Piller BD, Krupa JA, Vinauger C, Benoit JB. J Exp Bio DOI: 10.1242/jeb.244032

Species-Specificity in Thermopreference and CO2-Gated Heat-Seeking in Culex Mosquitoes Reinhold JM, Chandrasegaran K, Oker H, Crespo JE, Vinauger C, Lahondère C.  Insects DOI: 10.3390/insects13010092

Thermal biology of invasive Aedes mosquitoes in the context of climate change. Lahondère C, Bonizzoni M. Curr Opin Insect Sci DOI: 10.1016/j.cois.2022.100920

Particle-mediated Histotripsy for the Targeted Treatment of Catheter-based Medical Device Biofilms Childers C, Edsall C, Mehochko I, Mustafa W, Durmaz Y, Klibanov A, Rao J, Vlaisavljevich E. BME Frontiers 
Antibiotic perturbation of gut bacteria does not significantly alter host responses to ocular disease in a songbird species  
Weitzman CLBelden LK, May M, Langager MM, Dalloul RA, Hawley DMPeerJ  
DOI: 10.7717/peerj.13559

Hepatitis E virus infects brain microvascular endothelial cells, crosses the blood-brain barrier, and invades the central nervious system Tian D, Li W, Heffron CL, Wang B, Mahsoub HM, Sooryanarain H, Hassebroek AM, Clark-Deener S, LeRoith T, Meng XJ Proc Natl Acad Sci U S A  DOI: 10.1073/pnas.2201862119

Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors.
Fritzemeier R, Foster D, Peralta A, Payette M, Kharel Y, Huang T, Lynch KR, Santos WLJ Med Chem DOI: 10.1021/acs.jmedchem.1c02171

Ligand-free copper-catalyzed borylative defluorination: access to gem-difluoroallyl boronic acid derivatives. Gates AM, Jos S, Santos WL. Org Biomol Chem  DOI: 10.1039/d1ob01533h

Long-read metagenomic sequencing reveals shifts in associations of antibiotic resistance genes with mobile genetic elements from sewage to activated sludge. Dai D, Brown C, Bürgmann H, Larsson DGJ, Nambi I, Zhang T, Flach CF, Pruden A, Vikesland PJ. Microbiome
DOI: 10.1186/s40168-021-01216-5

Occurrence of opportunistic pathogens in private wells after major flooding events: A four state molecular survey. Mapili K, Rhoads WJ, Coughter M, Pieper KJ, Edwards MA, Pruden A. Sci Total Environ 
DOI: 10.1016/j.scitotenv.2022.153901

Establishment of a gnotobiotic pig model of Clostridioides difficile infection and disease  Nyblade C, Parreno V, Zhou P, Hensley C, Oakes V, Mahsoub HM, Kiley K, Frazier M, Frazier A, Zhang Y, Feng H, Yuan L. Gut Pathog  DOI: 10.1186/s13099-022-00496-y

Successful restoration of archived ovine formalin fixed paraffin-embedded tissue DNA and single nucleotide polymorphism analysisKravitz A, Tyler R, Manohar BM, Ronald BSM, Collins MT, Sriranganathan N. Vet Res Commun  DOI: 10.1007/s11259-022-09937-0

A Reduced F420-Dependent Nitrite Reductase in an Anaerobic Methanotrophic Archaeon Heryakusuma C, Susanti D, Yu H, Li Z, Purwantini E, Hettich RL, Orphan VJ, Mukhopadhyay B. J Bacteriol 
DOI: 10.1128/jb.00078-22

Simulations of cross-amyloid aggregation of amyloid-β and islet amyloid polypeptide fragments Kawecki GE, King KM, Cramer NA, Bevan DR, Brown AM. Biophys J 
DOI: 10.1016/j.bpj.2022.05.007
 
Help us advertise the ID IGEP program and recruit students. 
Please consider showing this slide at the end of any upcoming conference presentations and /or in any undergraduate classes you are teaching.  
ID IGEP Powerpoint Slide - Click here to download
COVID-19 Outreach Activities by CeZAP Affiliated Faculty Linsey Marr
 

COVID-19 Publications by CeZAP Affiliated Faculty
 
Vaccine Effectiveness during Outbreak of COVID-19 Alpha (B.1.1.7) Variant in Men’s Correctional Facility, United States. Silverman RA, Ceci A, Cohen A, Helmick M, Short E, Bordwine P, Friedlander MJ, and Finkielstein CV.  Emerg Infect Dis. DOI: 10.3201/eid2807.220091

Modeling waning and boosting of COVID-19 in Canada with vaccination  Childs LM, Dick DW, Feng Z, Heffernan J, Li J, Rost G. Epidemics  DOI: 10.1016/j.epidem.2022.100583
 
Evidence for a semisolid phase state of aerosols and droplets relevant to the airborne and surface survival of pathogens. Huynh E, Olinger A, Woolley D, Kohli RK, Choczynski JM, Davies JF, Lin K, Marr LC, Davis RD. Proc Natl Acad Sci U S ADOI: 10.1073/pnas.2109750119
 
Filtration evaluation of expired elastomeric P-100 filter cartridges after months of real-world use during the coronavirus disease 2019 (COVID-19) pandemic.
Baffoe-Bonnie AW, Zhang KS, Pan J, Simpkins K, Marr LC. Infect Control Hosp Epidemiol. DOI: 10.1017/ice.2021.104

Effect of Surface Porosity on SARS-CoV-2 Fomite Infectivity. Hosseini M, Poon LLM, Chin AWH, Ducker WA. ACS Omega  DOI: 10.1021/acsomega.1c06880

Untangling the changing impact of non-pharmaceutical interventions and vaccination on European COVID-19 trajectories. Ge Y, Zhang WB, Wu X, Ruktanonchai CW, Liu H, Wang J, Song Y, Liu M, Yan W, Yang J, Cleary E, Qader SH, Atuhaire F, Ruktanonchai NW, Tatem AJ, Lai S. Nat Commun DOI: 10.1038/s41467-022-30897-1
Recent Research Grants Awarded to CeZAP Affiliated Faculty
  • “Development and characterization of a sublethal-sequelae mouse model of EEEV infection”
    • PI Kylene Kehn-Hall, Co-PI: Michelle Theus (Virginia Tech) and Barney Bishop (George Mason  University)
    • TOTAL AWARD: $2,171,347 (DIRECT: $1,599,400; INDIRECT: $571,947)
The major goals of this project are 1) Determine the cognitive impact of EEEV infection. 2) Identify circulating correlates of neuropathology. 3) Determine the host responses that contribute to EEEV-induced cognitive defects, and 4) Perform proof-of-concept therapeutic testing in the EEEV neurological sequelae model.
  • NIH National Cancer Institute, National Institutes of Health"Deploying Histropsy Based Tumor Ablation Strategies to Treat Pancreatic Cancer" 
    • PI Irving Coy Allen
Outreach activities by CeZAP affiliated faculty
Lijuan Yuan recently gave an invited seminar at the US Association for Gnotobiotics. "Perfecting the gnotobiotic pig model system for the study of human enteric viruses and vaccines"

The following CeZAP affiliated faculty were recently featured on Podcasts:

The People's Pharmacy The Peoples Perspecitve on Medicine
Show 1227: What Do You Need to Know About Airborne Viruses? 
  • Linsey Marr discusses how ventilation is crucial when it comes to preventing the spread of airborne viruses. Why is nobody listening? Learn how to protect yourself!  LINK TO PODCAST>>
Ticktective: A Straight-Forward Explanation of the Complications With Lyme Diagnostics and a Potential New Direct Detection Test
  • Brandon Jutras explains why there are no accurate tests for Lyme disease available and how his research is looking to change that LINK TO PODCAST>>

To Foster and Promote a Cohesive and Synergistic Environment for Interdisciplinary and Collaborative Research







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