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2022  CeZAP Infectious Diseases Symposium 

October 7, 2022 
8:30 am - 5:30 pm

The Inn at Virginia Tech

 
Registration Deadline September 16 
Click HERE to Register
Registration is FREE but you must sign up by Sept 16th

Keynote speakers include: 
CAPT Jennifer McQuiston, DVM, MS
Deputy Director, Division of High Consequence Pathogens and Pathology
Centers for Disease Control and Prevention

“CDC’s Division of High Consequence Pathogens and Pathology: Recent Outbreak, Future Horizons”

T. Jake Liang, M.D.
National Institutes of Health
Chief of Liver Diseases Branch and NIH Distinguished Investigator

NIH Distinguished Investigator
“A Drug’s Purpose: From Erectile Dysfunction, Allergy to Hepatitis C and Covid-19”

Sue VandeWoude, DVM
University Distinguished Professor
Director, One Health Institute 
Colorado State University 

“Endogenous-exogenous Viral Interactions during Feline Leukemia Virus Infection”
 
Symposium is sponsored by the Fralin Life Sciences Institute
2022 CeZAP Infectious Diseases Symposium website
Kylene Kehn-Hall named CeZAP Director
Kylene Kehn-Hall, Professor in the Department of Biomedical Sciences and Pathobiology and former Associate Director of CeZAP has been named CeZAP Director.  Kylene is a world-class scientist with numerous leadership experience. Her research focuses on understanding the mechanism of viral pathogenesis and developing antivirals for vector-borne and zoonotic diseases. She is well funded by NIH, DoD (DTRA, CDMRP), and private sectors with multi-million dollar active research programs. Importantly, Kylene is very passionate about CeZAP and its mission, and has been actively participating in various CeZAP activities. She has been the Associate Director of CeZAP for the past 8 months, has served on the CeZAP Advisory and Leadership Committee from the beginning, and has taught (as the course leader) a 2-credit infectious disease course for the CeZAP’s ID IGEP program. Prior to joining Virginia Tech, Kylene was the Director of Biosciences PhD graduate program at George Mason University and was also the Associate Director of the School of Systems Biology at GMU.
Virginia Tech researcher to test vaccine for norovirus

Lijuan Yuan, professor of virology and immunology at the Virginia-Maryland College of Veterinary Medicine at Virginia Tech, will evaluate a potential live oral vaccine for norovirus, the No. 1 cause of foodborne illness. 

"Together, rotavirus and norovirus cause over 415,000 deaths every year, and norovirus also has a very significant burden even in the countries that don’t have a lot of deaths. The economic cost is huge, $4.2 billion in direct costs and $60 billion in indirect societal costs. You hear about norovirus outbreaks on the news all the time in hospitals, nursing homes, and cruise ships and how it's closing down restaurants, so it's got a lot of economic implications,” said Yuan. READ MORE>>

Special Study: Critical Analysis of Infectious Disease Literature
GRAD5984 CRN 91991

TUESDAYS 12:30pm - 1:45pm, Fralin Auditorium

Course Leaders: James Weger-Lucarelli weger@vt.edu & Ann Stevens ams@vt.edu 

This fall we are excited to offer a formal literature course, GRAD 5984, Special Study: Critical Analysis of Infectious Disease Literature, a 1 credit course on Tuesday at 12 - 1:45 pm where students will gain skills in interpreting primary research, critical thinking, working as a team, discussing scientific concepts, and constructive criticism of research.  The primary literature for review will be in the general topic of the weekly CeZAP seminar or written by the weekly CeZAP seminar speaker. While this class is for the first year students, all are welcome on a voluntary basis and encouraged to attend. Please contact James Weger weger@vt.edu or Ann Stevens ams@vt.edu to be added to the course Canvas site to have access to the papers being discussed each week.  

Syllabus GRAD 5984
Distinguished Speaker Seminar Series in Infectious Disease

Fall 2022 Seminar Schedule
Thursdays at 12:30pm – 1:30pm

Fralin Hall Auditorium


August 25, 2022:
Jonathan Auguste, Ph.D. 
 Assistant Professor, Department of Entomology, CALS 
"Enemy of my Enemy: Employing an insect-specific virus in the fight against Zika virus"

September 1, 2022: 
Maria Elena Bottazzi, Ph.D. 
 
Associate Dean, National School of Tropical Medicine, Baylor College of Medicine
"Academic Creativity, Strategic Alliances and Diplomacy: Behind the scenes of a COVID-19 vaccine suitable for global access"

September 8, 2022:

David Riglar, Ph.D., Sir Henry Dale Research Fellow, Imperial College London
"Using synthetic biology to combat the double-edged-sword of spatially varying host-microbiome interactions"

September 15, 2022:
Luis Escobar Ph.D.  
Assistant Professor, Department of Fish and Wildlife Conservation, CNRE
 "Linkages Between Climate Change, Zoonotic Diseases and WildLife"

September 22, 2022:
ID IGEP Research Rotation Presentations

September 29, 2022:
Hanh Lam, Ph.D. 
 Associate Professor of Biological Sciences, COS 
"Probing host- microbe interactions for pathogen specific antimicrobials"

October 6, 2022:
Matha Clokie Ph.D.
  
Professor, University of Leicester
"The use of phages to remove intestinal pathogens from poultry and swine"

October 13, 2022:
Brian Kvitko, Ph.D.
 
Associate Professor, University of Georgia
"A new paradigm for bacterial necrotrophs: chemical warfare"

October 20, 2022:
ID IGEP Research Rotation Presentations

October 27, 2022:
Leda Kobziar, Ph.D. 
Associate Professor, University of Idaho
“Catching, Counting, and Considering the Microbial Life Transported by Wildfire Smoke Plumes”

November 3, 2022:
Gregory Glass, Ph.D.
  
Professor, University of Florida
"Nuances and Hidden Implications In Disease Dynamics"

November 10, 2022:
Kevin Lahmers DVM,  Ph.D, DACVP
 
Clinical Associate Professor, Virginia-Maryland College of Veterinary Medicine

November 17, 2022:
ID IGEP Research Rotation Presentations

December 1, 2022:
John Aggrey, Ph.D.
  
Postdoctoral Associate, Department of Science, Technology, and Society, CLAHS
"Invisible Visibilities: Risk Infrastructure and Epidemiological Obfuscation in Epidemics"

Recent Publications by CeZAP Affiliated Faculty
Prevalence and Associated Risk Factors of African Animal Trypanosomiasis in Cattle in Lambwe, Kenya Okello I, Mafie E, Eastwood G, Nzalawahe J, Mboera LEG, Onyoyo S Journal of Parasitology Research DOI:10.1155/2022/5984376

Two mutations in the ORF1 of genotype 1 hepatitis E virus enhance virus replication and may associate with fulminant hepatic failure. Wang B, Tian D, Sooryanarain H, Mahsoub HM, Heffron CL, Hassebroek AM, Meng XJ. Proc Natl Acad Sci U S A. DOI: 10.1073/pnas.2207503119

Declines in prevalence alter the optimal level of sexual investment for the malaria parasite Plasmodium falciparum   Early AM, Camponovo F, Pelleau S, Cerqueira GC, Lazrek Y, Volney B, Carrasquilla M, de Thoisy B, Buckee CO, Childs LM, Musset L, Neafsey DE.  Proc Natl Acad Sci U S A DOI: 10.1073/pnas.2122165119. 

Prolonged shedding of Zika virus in human semen is associated with male reproductive tract inflammation.Vogt MB, McDonald EM, Delorey M, Mead PS, Hook SA, Hinckley AF, Werre SR, Brault AC, Duggal NK. J Infect Dis. DOI: 10.1093/infdis/jiac329

Mining transcriptome data: Utilization of environmentally regulated promoters for protein expression and purification in Clostridium perfringensSoncini SR, Camper GJ, Melville SB. J Microbiol Methods DOI: 10.1016/j.mimet.2022.106519.

Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney.
Tanaka S, Zheng S, Kharel Y, Fritzemeier RG, Huang T, Foster D, Poudel N, Goggins E, Yamaoka Y, Rudnicka KP, Lipsey JE, Radel HV, Ryuh SM, Inoue T, Yao J, Rosin DL, Schwab SR, Santos WL, Lynch KR, Okusa MD. Sci Transl Med DOI: 10.1126/scitranslmed.abj2681
Complete Genome Sequence of Providencia stuartii CMC-4104, Isolated from a Human Splenic Abscess, Containing Multiple Copies of NDM-1 and PER-1 Carbapenem Resistance Genes Rao J, Stornelli NK, Everson NA, McDaniel LF, Gomez De La Espriella M, Faulhaber JR, Todd SM, Lahmers KK, Jensen RV. Microbiol Resour Announce DOI: 10.1128/mra.00514-22

Wearable adjunct ozone and antibiotic therapy system for treatment of Gram-negative dermal bacterial infection.Roth A, Maruthamuthu MK, Nejati S, Krishnakumar A, Selvamani V, Sedaghat S, Nguyen J, Seleem MN, Rahimi R. Sci Rep  DOI: 10.1038/s41598-022-17495-3

Selective targeting of biting females to control mosquito-borne infectious diseasesKojin BB, Compton A, Adelman ZN, Tu Z. Trends Parasitol
DOI: 10.1016/j.pt.2022.05.012 

Visualization of the Linear and Spatial Organization of Chromosomes in Mosquitoes.Liang J, Bondarenko SM, Sharakhov IV, Sharakhova MV. Cold Spring Harb Protoc. DOI: 10.1101/pdb.top107732

Mechanical limitation of bacterial motility mediated by growing cell chains. McMahon SG, Melville SB, Chen J. Biophys J. DOI: 10.1016/j.bpj.2022.05.012

Optimizing Pooled Testing for Estimating the Prevalence of Multiple Diseases.Warasi MS, Hungerford LL, Lahmers K. J Agric Biol Environ  DOI: 10.1007/s13253-022-00511-4

Flagellotropic Bacteriophages: Opportunities and Challenges for Antimicrobial Applications Esteves N, Scharf BE. Int J Mol Sci DOI: 103390/ijms23137084
COVID-19 Publications by CeZAP Affiliated Faculty

Vaccine Effectiveness during Outbreak of COVID-19 Alpha (B.1.1.7) Variant in Men's Correctional Facility, United States Silverman, R. Ceci A, Cohen A, Helmick M, Short E, Bordwine P, Friedlander M, Finkielstein C.  Emerg Infect Dis DOI: 10.3201/eid2807.220091
Recent Research Grants Awarded to CeZAP Affiliated Faculty
  • NIH 1R35GM147290-01 Coevolutionary Dynamics and Gene Exchange Between Nucleo-Cytoplasmic Large DNA Viruses and Eukaryotes
    • PI Frank Aylward
    • $$1,861,244  08/22 - 07/27
Nucleo-Cytoplasmic Large DNA Viruses (NCLDVs) include some of the deadliest human and vertebrate pathogens known. This work will provide important insights into the past and present evolutionary processes that shape these viruses, while also laying the foundation for a new model system that can be leveraged to examine molecular dynamics of NCLDV infection in more detail.
Welcome new CeZAP affiliated faculty members!
  • Anna Duraj-Thatte
    •   Assistant Professor, Biological Systems Engineering, College of Engineering & College of Agriculture and Life Sciences
  • Carla V. Finkielstein   
    • Scientific Director, Molecular Diagnostics Laboratory, Fralin Biomedical Research Institute
  • Emily Gentry 
    • Assistant Professor, Chemistry, College of Science
  • Erin Gloag  
    • Assistant Professor, Bacteriology, Virginia-Maryland College of Veterinary Medicine.
  • Jingqiu Liao 
    •  Assistant Professor, Civil and Environmental Engineering, College of Engineering 
  • Wujin Sun 
    • Assistant Professor, Biological Systems Engineering, College of Engineering
The ID IGEP program welcomes the 2nd class of cohorts starting Fall 2022!  Members of the 1st and 2nd cohort gathered recently to meet at a social.  

Current VT Graduate Students: 

Any current VT graduate student working with an ID IGEP faculty member, having research interests related to infectious disease topics, and in good academic standing, may apply to become an affiliate member of the ID IGEP community by filling out a survey HERE.

ID IGEP Affiliated student members will become part of the interdisciplinary ID IGEP
community across the VT campus and will be able to list programmatic affiliation on their CVs.  As such they will receive Email communication and will be encouraged to participate in ID IGEP activities (including the Topics in Infectious Disease course, seminar series, and research symposia)

Help us advertise the ID IGEP program and recruit students. 

Please consider showing this slide at the end of any upcoming conference presentations and /or in any undergraduate classes you are teaching.  
ID IGEP Powerpoint Slide - Click here to download
Congratulations to the following CeZAP affiliated faculty recipients the 2022-23 ICSE Scholars Program READ MORE>>

Deploying an Upscaled Silver-Ceramic Technology to Disinfect Drinking Water in School and Community-based Settings

  • PI Luke Juran, co-PI Alasdair Cohen
The researchers are looking at the ability to disinfect children’s drinking water stored in large tanks, using silver-ceramic technology, in four identified schools in the poorest regions of India. They also will conduct surveys to determine the effectiveness of and need for interventions regarding healthy washing and sanitization knowledge in the schools and surrounding communities.


Understanding the Economic and Health Outcomes Associated with Supplemental Potable Water Use in Central Appalachia

  • PI: Leigh-Anne Krometis, Co-PIs: Kimberly Ellis, Alasdair Cohen, Austin Gray, and Kang Xia
Researchers want to quantify the economic and health implications of using multiple water sources, such as bottled water, when in-home piped water is not accessible. 
Engineering researchers are partners in the lab - and in life

Virginia Tech researchers Padma Rajagopalan and T.M. Murali go beyond the boundaries of engineering disciplines to gain insights into emerging viral infections, such as COVID-19.  READ MORE >>

To Foster and Promote a Cohesive and Synergistic Environment for Interdisciplinary and Collaborative Research







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