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| Validation of an Integrated Risk Tool, Including Polygenic Risk Score, for Atherosclerotic Cardiovascular Disease in Multiple Ethnicities and Ancestries. |
Weale ME, Riveros-Mckay F, Selzam S, Seth P, Moore R, Tarran WA, Gradovich E, Giner-Delgado C, Palmer D, Wells D, Saffari A, Sivley RM, Lachapelle AS, Wand H, Clarke SL, Knowles JW, O'Sullivan JW, Ashley EA, McVean G, Plagnol V, Donnelly P.
Am J Cardiol. 2021 Jun 1;148:157-164. doi: 10.1016/j.amjcard.2021.02.032. |
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| Automated coronary calcium scoring using deep learning with multicenter external validation. |
Eng D, Chute C, Khandwala N, Rajpurkar P, Long J, Shleifer S, Khalaf MH, Sandhu AT, Rodriguez F, Maron DJ, Seyyedi S, Marin D, Golub I, Budoff M, Kitamura F, Takahashi MS, Filice RW, Shah R, Mongan J, Kallianos K, Langlotz CP, Lungren MP, Ng AY, Patel BN.
NPJ Digit Med. 2021 Jun 1;4(1):88. doi: 10.1038/s41746-021-00460-1. |
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| Association of the transthyretin variant V122I with polyneuropathy among individuals of African ancestry. |
Parker MM, Damrauer SM, Tcheandjieu C, Erbe D, Aldinc E, Hawkins PN, Gillmore JD, Hull LE, Lynch JA, Joseph J, Ticau S, Flynn-Carroll AO, Deaton AM, Ward LD, Assimes TL, Tsao PS, Chang KM, Rader DJ, Fitzgerald K, Vaishnaw AK, Hinkle G, Nioi P.
Sci Rep. 2021 Jun 2;11(1):11645. doi: 10.1038/s41598-021-91113-6. |
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| Impact of chronic kidney disease on hemoglobin among patients with peripheral artery disease treated with P2Y12 inhibitors: Insights from the EUCLID trial. |
Hsia J, Kavanagh ST, Hopley CW, Baumgartner I, Berger JS, Fowkes GR, Jones WS, Mahaffey KW, Norgren L, Patel MR, Rockhold F, Blomster J, Katona BG, Hiatt WR, Bonaca MP.
Vasc Med. 2021 Jun 3:1358863X211017641. doi: 10.1177/1358863X211017641. |
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| Smartphone-Based VO2max Measurement With Heart Snapshot in Clinical and Real-world Settings With a Diverse Population: Validation Study. |
Webster DE, Tummalacherla M, Higgins M, Wing D, Ashley E, Kelly VE, McConnell MV, Muse ED, Olgin JE, Mangravite LM, Godino J, Kellen MR, Omberg L.
JMIR Mhealth Uhealth. 2021 Jun 4;9(6):e26006. doi: 10.2196/26006. |
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| "Doctors can read about it, they can know about it, but they've never lived with it": How parents use social media throughout the diagnostic odyssey. |
Deuitch NT, Beckman E, Halley MC, Young JL, Reuter CM, Kohler J, Bernstein JA, Wheeler MT; Undiagnosed Diseases Network, Ormond KE, Tabor HK.
J Genet Couns. 2021 Jun 6. doi: 10.1002/jgc4.1438. |
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| Sex differences in congestive markers in patients hospitalized for acute heart failure. |
Espersen C, Campbell RT, Claggett B, Lewis EF, Groarke JD, Docherty KF, Lee MMY, Lindner M, Biering-Sørensen T, Solomon SD, McMurray JJV, Platz E.
ESC Heart Fail. 2021 Jun;8(3):1784-1795. doi: 10.1002/ehf2.13300. |
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| Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer. |
Ouyang X, Liu Y, Zhou Y, Guo J, Wei TT, Liu C, Lee B, Chen B, Zhang A, Casey KM, Wang L, Kooreman NG, Habtezion A, Engleman EG, Wu JC.
Stem Cell Reports. 2021 Jun 8;16(6):1468-1477. doi: 10.1016/j.stemcr.2021.04.004. |
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| Myocardial Viability Imaging using Manganese-Enhanced MRI in the First Hours after Myocardial Infarction. |
Jasmin NH, Thin MZ, Johnson RD, Jackson LH, Roberts TA, David AL, Lythgoe MF, Yang PC, Davidson SM, Camelliti P, Stuckey DJ.
Adv Sci (Weinh). 2021 Jun;8(11):e2003987. doi: 10.1002/advs.202003987. |
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| Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation. |
Hong L, Zhang M, Ly OT, Chen H, Sridhar A, Lambers E, Chalazan B, Youn SW, Maienschein-Cline M, Feferman L, Ong SG, Wu JC, Rehman J, Darbar D.
Stem Cell Reports. 2021 Jun 8;16(6):1542-1554. doi: 10.1016/j.stemcr.2021.04.019. |
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| Myocardial hypoxic stress mediates functional cardiac extracellular vesicle release. |
Anselmo A, Frank D, Papa L, Viviani Anselmi C, Di Pasquale E, Mazzola M, Panico C, Clemente F, Soldani C, Pagiatakis C, Hinkel R, Thalmann R, Kozlik-Feldmann R, Miragoli M, Carullo P, Vacchiano M, Chaves-Sanjuan A, Santo N, Losi MA, Ferrari MC, Puca AA, Christiansen V, Seoudy H, Freitag-Wolf S, Frey N, Dempfle A, Mercola M, Esposito G, Briguori C, Kupatt C, Condorelli G.
Eur Heart J. 2021 Jun 9:ehab247. doi: 10.1093/eurheartj/ehab247. |
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| Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy. |
Kimura K, Ooms A, Graf-Riesen K, Kuppusamy M, Unger A, Schuld J, Daerr J, Lother A, Geisen C, Hein L, Takahashi S, Li G, Röll W, Bloch W, van der Ven PFM, Linke WA, Wu SM, Huesgen PF, Höhfeld J, Fürst DO, Fleischmann BK, Hesse M.
Nat Commun. 2021 Jun 11;12(1):3575. doi: 10.1038/s41467-021-23858-7. |
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| The genetic architecture of Plakophilin 2 cardiomyopathy. |
Dries AM, Kirillova A, Reuter CM, Garcia J, Zouk H, Hawley M, Murray B, Tichnell C, Pilichou K, Protonotarios A, Medeiros-Domingo A, Kelly MA, Baras A, Ingles J, Semsarian C, Bauce B, Celeghin R, Basso C, Jongbloed JDH, Nussbaum RL, Funke B, Cerrone M, Mestroni L, Taylor MRG, Sinagra G, Merlo M, Saguner AM, Elliott PM, Syrris P, van Tintelen JP; Regeneron Genetics Center, James CA, Haggerty CM, Parikh VN.
Genet Med. 2021 Jun 12. doi: 10.1038/s41436-021-01233-7. |
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| Lipid-rich Plaques Detected by Near-infrared Spectroscopy Are More Frequently Exposed to High Shear Stress. |
Hartman EMJ, De Nisco G, Kok AM, Hoogendoorn A, Coenen A, Mastik F, Korteland SA, Nieman K, Gijsen FJH, van der Steen AFW, Daemen J, Wentzel JJ.
J Cardiovasc Transl Res. 2021 Jun;14(3):416-425. doi: 10.1007/s12265-020-10072-x. |
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| Racial and Ethnic Differences in Presentation and Outcomes for Patients Hospitalized With COVID-19: Findings From the American Heart Association's COVID-19 Cardiovascular Disease Registry. |
Rodriguez F, Solomon N, de Lemos JA, Das SR, Morrow DA, Bradley SM, Elkind MSV, Williams JH, Holmes D, Matsouaka RA, Gupta D, Gluckman TJ, Abdalla M, Albert MA, Yancy CW, Wang TY.
Circulation. 2021 Jun 15;143(24):2332-2342. doi: 10.1161/CIRCULATIONAHA.120.052278. |
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| Association of Heart Failure With Outcomes Among Patients With Peripheral Artery Disease: Insights From EUCLID. |
Samsky MD, Hellkamp A, Hiatt WR, Fowkes FGR, Baumgartner I, Berger JS, Katona BG, Mahaffey KW, Norgren L, Blomster JI, Rockhold FW, DeVore AD, Patel MR, Jones WS.
J Am Heart Assoc. 2021 Jun 15;10(12):e018684. doi: 10.1161/JAHA.120.018684. |
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| Author Correction: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. |
Yang Z, Shi J, Xie J, Wang Y, Sun J, Liu T, Zhao Y, Zhao X, Wang X, Ma Y, Malkoc V, Chiang C, Deng W, Chen Y, Fu Y, Kwak KJ, Fan Y, Kang C, Yin C, Rhee J, Bertani P, Otero J, Lu W, Yun K, Lee AS, Jiang W, Teng L, Kim BYS, Lee LJ.
Nat Biomed Eng. 2021 Jun 15. doi: 10.1038/s41551-021-00725-w. |
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| Modest Gains After an 8-Week Exercise Program Correlate With Reductions in Non-traditional Markers of Cardiovascular Risk. |
Liang G, Huang X, Hirsch J, Mehmi S, Fonda H, Chan K, Huang NF, Aalami O, Froelicher VF, Lee DP, Myers J, Lee AS, Nguyen PK.
Front Cardiovasc Med. 2021 Jun 17;8:669110. doi: 10.3389/fcvm.2021.669110. eCollection 2021. |
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| Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease. |
Levin MG, Zuber V, Walker VM, Klarin D, Lynch J, Malik R, Aday AW, Bottolo L, Pradhan AD, Dichgans M, Chang KM, Rader DJ, Tsao PS, Voight BF, Gill D, Burgess S, Damrauer SM; VA Million Veteran Program.
Circulation. 2021 Jun 18. doi: 10.1161/CIRCULATIONAHA.121.053797. |
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| Clonal hematopoiesis associated with epigenetic aging and clinical outcomes. |
Nachun D, Lu AT, Bick AG, Natarajan P, Weinstock J, Szeto MD, Kathiresan S, Abecasis G, Taylor KD, Guo X, Tracy R, Durda P, Liu Y, Johnson C, Rich SS, Van Den Berg D, Laurie C, Blackwell T, Papanicolaou GJ, Correa A, Raffield LM, Johnson AD, Murabito J, Manson JE, Desai P, Kooperberg C, Assimes TL, Levy D, Rotter JI, Reiner AP, Whitsel EA, Wilson JG, Horvath S, Jaiswal S; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium.
Aging Cell. 2021 Jun;20(6):e13366. doi: 10.1111/acel.13366. |
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| Association of Apparent Treatment-Resistant Hypertension With Differential Risk of End-Stage Kidney Disease Across Racial Groups in the Million Veteran Program. |
Akwo EA, Robinson-Cohen C, Chung CP, Shah SC, Brown NJ, Ikizler TA, Wilson OD, Rowan BX, Shuey MM, Siew ED, Luther JM, Giri A, Hellwege JN, Velez Edwards DR, Roumie CL, Tao R, Tsao PS, Gaziano JM, Wilson PWF, O'Donnell CJ, Edwards TL, Kovesdy CP, Hung AM; VA Million Veteran Program.
Hypertension. 2021 Jun 21:HYPERTENSIONAHA12016181. doi: 10.1161/HYPERTENSIONAHA.120.16181. |
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| Right Ventricle Remodeling Metabolic Signature in Experimental Pulmonary Hypertension Models of Chronic Hypoxia and Monocrotaline Exposure. |
Hautbergue T, Antigny F, Boët A, Haddad F, Masson B, Lambert M, Delaporte A, Menager JB, Savale L, Pavec JL, Fadel E, Humbert M, Junot C, Fenaille F, Colsch B, Mercier O.
Cells. 2021 Jun 21;10(6):1559. doi: 10.3390/cells10061559. |
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| Cardiovascular Procedural Deferral and Outcomes over COVID-19 Pandemic Phases: A Multi-Center Study. |
Yong CM, Spinelli KJ, Chiu ST, Jones B, Penny B, Gummidipundi S, Beach S, Perino A, Turakhia M, Heidenreich P, Gluckman TJ.
Am Heart J. 2021 Jun 25:S0002-8703(21)00167-8. doi: 10.1016/j.ahj.2021.06.011. |
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| Severe Pulmonary Arterial Hypertension is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency. |
Sweatt AJ, Miyagawa K, Rhodes CJ, Taylor S, Del Rosario PA, Hsi A, Haddad F, Spiekerkoetter E, Bental-Roof M, Bland RD, Swietlik EM, Gräf S, Wilkins MR, Morrell NW, Nicolls MR, Rabinovitch M, Zamanian RT.
Chest. 2021 Jun 25:S0012-3692(21)01255-1. doi: 10.1016/j.chest.2021.06.028. |
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| A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids. |
Jhun MA, Mendelson M, Wilson R, Gondalia R, Joehanes R, Salfati E, Zhao X, Braun KVE, Do AN, Hedman ÅK, Zhang T, Carnero-Montoro E, Shen J, Bartz TM, Brody JA, Montasser ME, O'Connell JR, Yao C, Xia R, Boerwinkle E, Grove M, Guan W, Liliane P, Singmann P, Müller-Nurasyid M, Meitinger T, Gieger C, Peters A, Zhao W, Ware EB, Smith JA, Dhana K, van Meurs J, Uitterlinden A, Ikram MA, Ghanbari M, Zhi D, Gustafsson S, Lind L, Li S, Sun D, Spector TD, Chen YI, Damcott C, Shuldiner AR, Absher DM, Horvath S, Tsao PS, Kardia S, Psaty BM, Sotoodehnia N, Bell JT, Ingelsson E, Chen W, Dehghan A, Arnett DK, Waldenberger M, Hou L, Whitsel EA, Baccarelli A, Levy D, Fornage M, Irvin MR, Assimes TL.
Nat Commun. 2021 Jun 28;12(1):3987. doi: 10.1038/s41467-021-23899-y.
PMID: 34183656 |
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| Genetic Evidence for Repurposing of GLP1R (Glucagon-Like Peptide-1 Receptor) Agonists to Prevent Heart Failure. |
Daghlas I, Karhunen V, Ray D, Zuber V, Burgess S, Tsao PS, Lynch JA, Lee KM, Voight BF, Chang KM, Baker EH, Damrauer SM, Howson JMM, Vujkovic M, Gill D.
J Am Heart Assoc. 2021 Jun 29:e020331. doi: 10.1161/JAHA.120.020331. |
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| Patient Characteristics, Care Patterns, and Outcomes of Atrial Fibrillation Associated Hospitalizations in Patients with Chronic Kidney Disease and End-Stage Renal Disease. |
Kumar N, Xu H, Garg N, Pandey A, Matsouaka RA, Field ME, Turakhia MP, Piccini JP, Lewis WR, Fonarow GC.
Am Heart J. 2021 Jun 30:S0002-8703(21)00175-7. doi: 10.1016/j.ahj.2021.06.012. |
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| Use of donor-derived-cell-free DNA as a marker of early allograft injury in primary graft dysfunction (PGD) to predict the risk of chronic lung allograft dysfunction (CLAD). |
Keller M, Bush E, Diamond JM, Shah P, Matthew J, Brown AW, Sun J, Timofte I, Kong H, Tunc I, Luikart H, Iacono A, Nathan SD, Khush KK, Orens J, Jang M, Agbor-Enoh S.
J Heart Lung Transplant. 2021 Jun;40(6):488-493. doi: 10.1016/j.healun.2021.02.008. |
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| Association Between Genetic Variation in Blood Pressure and Increased Lifetime Risk of Peripheral Artery Disease. |
Levin MG, Klarin D, Walker VM, Gill D, Lynch J, Hellwege JN, Keaton JM, Lee KM, Assimes TL, Natarajan P, Hung AM, Edwards TL, Rader DJ, Gaziano JM, Davies NM, Tsao PS, Chang KM, Voight BF, Damrauer SM; VA Million Veteran Program.
Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):2027-2034. doi: 10.1161/ATVBAHA.120.315482. |
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| Does study subject diversity influence cardiology research site performance?: Insights from 2 U.S. National Coronary Stent Registries. |
Batchelor WB, Damluji AA, Yong C, Fiuzat M, Barnett SD, Kandzari DE, Sherwood MW, Epps KC, Tehrani BN, Allocco DJ, Meredith IT, Lindenfeld J, O'Connor CM, Mehran R.
Am Heart J. 2021 Jun;236:37-48. doi: 10.1016/j.ahj.2021.02.003. |
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| Rivaroxaban versus warfarin in patients with atrial fibrillation enrolled in Latin America: Insights from ROCKET AF. |
Blumer V, Rivera M, Corbalán R, Becker RC, Berkowitz SD, Breithardt G, Hacke W, Halperin JL, Hankey GJ, Mahaffey KW, Nessel CC, Piccini JP, Hellkamp AS, Singer DE, Fox KAA, Patel MR.
Am Heart J. 2021 Jun;236:4-12. doi: 10.1016/j.ahj.2021.02.004. |
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