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COVID-19
Knowledge and Library Services Evidence Update
Part of the Barts Health Education Academy
8/6/21
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Hello and welcome to this edition of Barts Health Knowledge and Library Services’ fortnightly COVID-19 evidence update.
Please let us know how we can improve future updates by providing feedback, and let us know if there are any resources or publications you would like us to feature.
To find out more about the library services available to you, including our highly-regarded literature searching service and desktop document supply service, please visit our WeShare page.
Feel free to cascade this update to any colleagues who might be interested. To subscribe to this update and others, please go to eepurl.com/dCz1lz
CONTENTS
News
Guidance and Institutional Publications
Latest Research Articles
Library COVID Update
New on our Website
Our Other Recent Updates
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FREE UPCOMING WEBINAR TONIGHT, 7pm - 8.30pm: Post COVID-19 syndrome (“Long covid”) Where are we now? from The Royal College of General Practitioners
"We will be joined by the Office of national statistics who will share new figures from June 2021 on those who are affected by the ongoing symptoms of COVID-19. We will hear from clinicians who have seen more than 1500 patient describe the variety of clinical presentations that are emerging and offer updated advice on how primary care can ensure effective assessments are undertaken. We will explore the condition in children and also hear from a patient with lived experience talking about recovery and hope. There will be an opportunity to ask questions and hear about the launch of the new RCGP resources to help you learn more and keep up to date with the evidence as it changes..."
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From Health Policy Insight: Editorial Wednesday 26 May 2021: The People’s Dominic Show
Report on The PM’s former chief advisor Dominic Cummings giving evidence to the Commons Health/Science select committees’ joint ‘lessons learned’.
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From Department of Health and Social Care: Weekly statistics for NHS Test and Trace (England): 20 May to 26 May 2021
"The latest NHS Test and Trace figures show the highest weekly number of people testing positive since April..."
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From the Medicines and Healthcare products Regulatory Agency:
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From The European Medicines Agency: First COVID-19 vaccine approved for children aged 12 to 15 in EU
"EMA’s human medicines committee (CHMP) has recommended granting an extension of indication for the COVID-19 vaccine Comirnaty to include use in children aged 12 to 15. The vaccine is already approved for use in adults and adolescents aged 16 and above..."
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From Public Health England: [Updated] COVID-19: Guidance for maintaining services within health and care settings Infection prevention and control recommendations Version 1.2
"The updated guidance obliges NHS organisations to assess the risk that covid-19 poses to staff and to act to mitigate any risks, such as by providing higher grade PPE including FFP3 masks. These risk assessments should include evaluations of ventilation, operational capacity, and the prevalence of infections including new variants of concern in the local area..." [BMJ News]
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From www.Gov.uk: How the world should prepare for the next pandemic
"Patrick Vallance writes about the aim to have vaccines and therapeutics available at scale within 100 days..."
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From European Centre for Disease Prevention and Control: Interim public health considerations for COVID-19 vaccination of adolescents in the EU/EEA
"This technical report provides a set of interim public health considerations to support EU/EEA public health authorities taking decisions on the administration of COVID-19 vaccines to adolescents (12- to 18-year-olds). As new evidence is continuously being generated and safety monitored on an ongoing basis, it is essential to consider the latest available information and recommendations issued by regulatory and public health authorities at national level..."
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From NHS Employers: Supporting recovery after long COVID
"We have produced guidance on how organisations can work with line managers to support staff in recovery from long COVID. The information, which was produced in partnership with NHS health and wellbeing leads, focuses on: facilitating a safe return to work for staff with long COVID; working with your occupational health team to support staff; supporting staff who are at work with long COVID; supporting staff that are off sick with long COVID; a range of good practice examples from NHS organisations that have supported staff with long COVID..."
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From The All-Party Parliamentary Group on Coronavirus: Hancock must apologise to long Covid patients left waiting over 100 days for treatment
"The APPG on Coronavirus has published research revealing a ‘postcode lottery of care’ for long Covid treatment, with some patients waiting for 127 days while others were treated within four days..."
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SARS-CoV-2 variants, spike mutations and immune escape
"We summarize the literature on mutations of the SARS-CoV-2 spike protein, the primary antigen, focusing on their impacts on antigenicity and contextualizing them in the protein structure, and discuss them in the context of observed mutation frequencies in global sequence datasets..."
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[Preprint] Characterising long term Covid-19: a living systematic review
"Thirty-nine studies were included: 32 cohort, six cross-sectional, and one case-control. Most showed high or moderate risk of bias. None were set in low-income countries, limited studies included children. Studies reported on 10,951 people (48% female) in 12 countries. Most followed-up post hospital discharge (78%, 8520/10951). The longest mean follow-up was 221.7 (SD: 10.9) days post Covid-19 onset. An extensive range of symptoms with wide prevalence was reported, most commonly weakness (41%; 95% CI 25% to 59%), malaise (33%; 95% CI 15% to 57%), fatigue (31%; 95% CI 24% to 39%), concentration impairment (26%; 95% CI 21% to 32%), and breathlessness (25%; 95% CI 18% to 34%). Other frequent symptoms included musculoskeletal, neurological, and psychological. 37% (95% CI 18% to 60%) of people reported reduced quality of life..."
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[Research letter] Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination
"To determine vaccine-induced NAb escape by B.1.617.2 and compare activity to previous strains with existing estimates for population-based vaccine efficacy, we carried out an initial analysis of the Legacy study, established in January, 2021, by University College London Hospital and the Francis Crick Institute in London, UK, to track serological responses to vaccination in prospectively recruited staff volunteers..."
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[Preprint] A Systematic Review of COVID - 19 Induced Myocarditis - Symptomatology, Prognosis, and Clinical Findings
"This systematic review included 22 studies and 37 patients. Eight patients (36%) were confirmed myocarditis, while the rest were possible myocarditis. Most patients had elevated cardiac biomarkers, including troponin, CRP, CK, CK-MB, and NT-pro BNP. Electrocardiogram results noted tachycardia (47%), left ventricular hypertrophy (50%), ST-segment alterations (41%), and T wave inversion (18%). Echocardiography presented reduced LVEF (77%), left ventricle abnormalities (34%), right ventricle aberrations (12%), and pericardial effusion (71%). Further, CMR showed reduced myocardial edema (75%), non-ischemic patterns (50%), and hypokinesis (26%). The mortality was significant at 25%..."
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[Preprint] Prevalence of long-term effects in individuals diagnosed with COVID-19: a living systematic review
"Of the 2807 unique citations, 36 observational studies met our inclusion criteria. Over 100 post COVID-19 conditions were reported in laboratory-confirmed individuals. Eighty-three percent (95%CI: 65-93%; low certainty) and 56% (95%CI: 34-75%; very low certainty) reported persistence or presence of one or more symptoms in the short- and long-term, respectively. The most prevalent symptoms in both periods included: fatigue, general pain or discomfort, sleep disturbances, shortness of breath and anxiety or depression (point estimates ranging from 22-51%; low to very low certainty)..."
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[Preprint] Safety of COVID-19 vaccines, their components or their platforms for pregnant women: A rapid review
"We identified 6768 records, 256 potentially eligible studies were assessed by full-text, and 37 clinical and non-clinical studies (38 reports, involving 2,397,715 pregnant women and 56 pregnant animals) and 12 pregnancy registries were included. Most studies (89%) were conducted in high-income countries. The most frequent study design was cohort studies (n=21), followed by surveillance studies, randomized controlled trials, and registry analyses. Most studies (76%) allowed comparisons between vaccinated and unvaccinated pregnant women (n=25) or animals (n=3) and reported exposures during the three trimesters of pregnancy..."
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[Preprint] The Influence of Coronavirus Disease-2019 (COVID-19) On Parkinson’s Disease: An Updated Systematic Review
"Of the 355 records located during the initial round of screening, 16 were included in the final synthesis. Of PD patients who tested positive for SARS-CoV-2, worsening motor symptoms and other viral-associated symptoms were reported. These symptoms included bradykinesia, tremors, gait disturbances, delirium and dementia, and severe spasms of arms and legs. Encephalopathy was presented in two of the included studies. Increased mortality rates were identified for hospitalized patients due to COVID-19 and PD as compared to other patient groups, albeit with limited generalizability due to high bias of included studies..."
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[Preprint] The isolated effect of age on the risk of COVID-19 severe outcomes: a systematic review with meta-analysis
"Our results show a best-possible quantification of the increase in COVID-19 disease severity due to age. Rather than implementing age thresholds, prevention programs should consider the continuous increase in risk. There is a need for continuous, high-quality research and “living” reviews to evaluate the evidence throughout the pandemic, as results may change due to varying circumstances..."
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[Preprint] The Influence of Coronavirus Disease-2019 (COVID-19) On Parkinson’s Disease: An Updated Systematic Review
"Of the 355 records located during the initial round of screening, 16 were included in the final synthesis. Of PD patients who tested positive for SARS-CoV-2, worsening motor symptoms and other viral-associated symptoms were reported. These symptoms included bradykinesia, tremors, gait disturbances, delirium and dementia, and severe spasms of arms and legs. Encephalopathy was presented in two of the included studies. Increased mortality rates were identified for hospitalized patients due to COVID-19 and PD as compared to other patient groups, albeit with limited generalizability due to high bias of included studies..."
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Telemedicine Implementation in COVID-19 ICU: Balancing Physical and Virtual Forms of Visibility
"The COVID-19 crisis drove healthcare institutions to rapidly develop new models of care based on integrating digital technologies for remote care with transformations in the hospital-built environment. The Sheba Medical Center in Israel created COVID-19 ICUs in an underground structure with an open-ward layout and telemedicine control rooms to remotely supervise, communicate, and support the operations in the contaminated zones. One unit had a physical visual connection between the control room and the contaminated zone through a window, while the other had only a virtual connection with digital technologies..."
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All staff are now required to sign-in, and wash their hands with the gel provided, when entering our libraries.
St Bart’s Hospital Library has moved back to its original space in the department of diagnostic imaging, on the ground floor of the KGV Building. It will be staffed from 10am-4pm, Monday to Friday, and available to staff 24/7. The phone no. there is 020 3465 5467.
At Whipps Cross and Newham Hospitals we offer comfortable seats and computer access, with tea and coffee, from 10am-4pm. Please check local notices for details. Staff can continue to access our 24/7 knowledge hubs (computer rooms) on each site.
Our Library Hub at the Royal London continues to be available to staff 24/7.
Please see our new website and our Digital Library WeShare page for more information.
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We've updated the resource collections within our COVID-19 pages; plus further services, resources, and NHS discounts have been added to our Wellbeing pages.
Our brand new Leadership and Management subject guide collects all our services and resources on the topic, and signposts to external help.
You can now search the entirety of our collection from the website homepage below via the Discovery search bar too...
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Read our latest monthly Leadership Update (published 7/6/21) here.
Read our latest Health Services Management Update (published 4/6/21) here.
Read our latest Inclusion and Diversity Update (published 28/5/21) here.
Read our previous COVID-19 Update (published 24/5/21) here.
Read our latest monthly Delirium in ICU Evidence Alert (published 17/5/21) here.
Read our latest Staff Wellbeing Update (published 13/5/21) here.
Read our latest COVID-19 and TB Update (published 5/5/21) here.
Read our round-up of research published by Barts Health authors in the month of April 2021 (published 4/5/21) here.
Read our latest Safer Surgery Update (published 18/5/21) here.
Catch up with all our archived updates on our Digital Library Weshare page.
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Happy to help.
If you require the full text of any of the articles mentioned above, or any other assistance, please email bartshealth.library@nhs.net
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