Regenerative Medicine
Video with 2020 Regenerative Medicine TIN Pilot Data Scheme (PDS) awardee
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In this video, 2020 Regenerative Medicine TIN PDS awardee Dr Hassan Rashidi, highlights his project titled “Dissecting the cross-talk between parenchymal and non-parenchymal derivatives within human pluripotent stem cell-derived 3D hepatospheres (3D Heps) using spatial transcriptomics”. Hassan also describes his transition to a career in academia and comments on the importance of basic science in the translational pathway.
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Repurposing
Video with 2020 Repurposing TIN Pilot Data Scheme (PDS) awardee
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This video highlights the work of Repurposing TIN PDS awardee Dr Pilar Acedo, with a project titled “Repurposing p53 reactivators for the treatment of pancreatic cancer”. Pilar highlights her work and the value of working in a hospital at UCL to incorporate the patient voice into her translational project.
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Repurposing
Repurposing TIN: Innovative approaches to accelerate drug repurposing (18th Nov, 2.30-4.40pm)
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In the fourth seminar of the Repurposing TIN series, partner organisations will describe how they have successfully furthered their mission to translating discoveries from the laboratory to marketplace for the benefit of patients.
We will discuss new (and non-traditional) collaboration, business and funding models arising to bridge stakeholders, and also how these partnerships have helped change prescribing policies and build a more supportive overall pathway.
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Small Molecules
PROTAC & AUTAC Opportunity for UCL researchers
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PROTACs/AUTACs are a new technology that chemically knocks-out a protein of interest by directing it to the Proteasome or to Autophagy. They are particularly useful for cell biology and in-vivo studies.
The Small Molecules TIN has purchased a stock of molecules suitable for modification into functional PROTACs. We have also purchased a stock of AUTAC4 (HY-W073762-Autophagy Ligand and HY-128837-Nutlin carboxylic acid, a mitophagy enhancer) that does not require further chemistry. These molecules are being made freely available to interested research groups across UCL.
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If you would like to take advantage of this opportunity to obtain a PROTAC or AUTAC for your research, please complete an expression of interest form below (we encourage you to do so at your earliest convenience, as there is limited stock available for these molecules).
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Other Translational Funding Opportunities
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MRC Developmental Pathway Funding Scheme (DPFS) outline
- Submission Deadline: 24th November 2021
The DPFS scheme is a key part of the MRC's Translational Research Strategy and supports the translation of fundamental discoveries toward benefits to human health. It funds the pre-clinical development and early clinical testing of novel therapeutics, devices and diagnostics, including “repurposing” of existing therapies.
The scheme supports academically led projects whose goals are to improve prevention, diagnosis, prognosis, or treatment of significant health needs, or that focus on developing research tools that increase the efficiency of developing interventions.
The Translational Research Group within UCL TRO provide support for MRC DPFS applications. If you would like to apply, please contact Translational Research Group Head, Dr Pamela Tranter (p.tranter@ucl.ac.uk).
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Sight Research UK Translational Research Award
- Submission Deadline: 30th November 2021
This Translational Research Award supports research projects with a clearly defined pathway to achieving patient benefit. Its goal is to help to accelerate the translation of scientific findings to the early stages of development of new therapies, devices, and diagnostics. Sight Research UK welcome projects that have robust commercial potential, likely to attract large scale follow-on funding from other charitable, statutory or industry funders.
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ACCELERATE Potential - a reminder
A reminder to sign up to ACCELERATE Potential to learn translational fundamentals. The programme provides an online, self-paced, introductory course covering the key elements of translational research and where to find support, is now for everyone to sign up!
The free online course outlines the skills and strategic elements needed to successfully translate a scientific idea to a healthcare setting and has been developed collaboratively with experts from across UCL and beyond. It will also help you to; identify where to go for support for translational research, describe the general translational research pathway and help you reflect on how you might make your work more translational to achieve further impact. The course also prominently features insights from researchers who are currently impacting healthcare with their work.
To learn more before signing up, watch this short video:
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The course is self-paced, with participants able to work through the content in their own time and is openly accessible to all at UCL and outside UCL. Upon completion of the course, participants will be eligible for a certificate of completion.
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