|
November 2021 NIDUS Newsletter
Network for Investigation of Delirium: Unifying Scientists
|
|
In this issue:
NIDUS II: A New Cycle
9th Annual NIDUS Delirium Boot Camp
January Webinar Career Development Award Research
Check Out the NIDUS Blog
Delirium Measurement Info Cards
Current Research Priority Areas
NIDUS Published Papers
|
|
NIDUS II: A New Cycle
NIDUS II has now launched! During its first five years, NIDUS achieved so many milestones, which we outlined in a past newsletter. Now, we're happy to announce NIDUS II!
So what's the difference between NIDUS II and NIDUS I? NIDUS I was the first grant cycle where we built much of our infrastructure, and sponsored many pilot grants for junior investigators. NIDUS II is a new grant cycle that began in July 2021.
Although there are a few different aims and focus areas, the overarching goal remains the same: To support and establish a collaborative network to advance scientific research on the causes, mechanisms, outcomes, diagnosis, prevention, and treatment of delirium in older adults. NIDUS II is still an inclusive resource for the worldwide delirium research community and remains an NIA-funded project. The new goal of NIDUS II is to use the NIDUS infrastructure to catalyze and complete collaborative research projects.
Below is a list of the NIDUS Cores and Task Forces:
|
|
9th Annual NIDUS Delirium Boot Camp
The 2021 NIDUS Delirium Boot Camp focused on the inter-relationship between delirium and ADRD was held on November 8 and 9, 2021. Founded in 2013, the 2021 Boot Camp, co-directed this year by Jan Busby Whitehead MD and John Devlin PharmD, and supported by the NIA (R13185760), brought together 12 diverse researcher mentees from various professions and clinical settings along with 4 junior faculty (prior Boot Camp alums) and 16 senior faculty researchers. Due to ongoing COVID-19 concerns, the 2021 Boot Camp was held virtually.
Over two days, senior faculty presented a number interactive delirium research-related didactic presentations, moderated networking sessions, provided CAM training, and facilitated a NIH-style mock review session where another mentee and two faculty who reviewed each research proposal, provided valuable feedback to the mentee.
Below are a few screenshots of this year’s Boot Camp. Also, for those who were unable to attend, we’ll make the recorded webinars available on the NIDUS website in the coming weeks.
The 10th Annual NIDUS Delirium Boot Camp will be held in the fall of 2022 (date TBD). Applications will open in early 2022. Please check the NIDUS website for updated information on the 2022 Boot Camp.
|
|
|
|
2021 Boot Camp co-directors: Jan Busby Whitehead MD and John Devlin PharmD
|
|
|
|
A 2021 NIDUS Boot Camp Mock Study session
|
|
|
|
Edward Marcantonio, MD, SM, explored CAM and delirium diagnosis in different contexts
|
|
NIDUS January Webinar - Career Development Award Research Mentoring Session
Our next webinar will feature Dr. Thomas M. Gill, Dr. Esther Oh, and Dr. Nicholas Reed. This session’s Moderator/Discussant will be Dr. Jan Busby Whitehead. Register via Zoom link below. All NIDUS webinars are free!
When: Wednesday, January 26, 2022, 2:00pm - 3:00pm EST
Detailed Agenda
- 2:00-2:20: Developing a Successful Career Development Award (Dr. Thomas M. Gill)
- 2:20-2:40: Career Development Awards: A Story of Success (Dr. Esther Oh & Dr. Nicholas Reed)
- 2:40-3:00: Q&A; Discussion moderated by Dr. Jan Busby Whitehead
Registration Link: link: https://zoom.us/meeting/register/tJUrcu2tqzwiEtVCxx1LXDx8Iw7Hd78cv5lS
Phone: +13126266799
Meeting ID: 916 5455 7881
Passcode: 129336
|
|
Check Out the NIDUS Blog
The NIDUS Blog features posts on a variety of topics related to delirium research with a focus on the core NIDUS II aims. Many blogs are authored by NIDUS Bootcamp alums. The latest blog post features Colm Cunningham, PhD, and his study Brain Vulnerability, Inflammation, and Energy Metabolism in Animal Models. New Blogs are posted monthly. If you haven’t already, we encourage you to check out the NIDUS Blog.
|
|
Other NIDUS Communications
In addition to the NIDUS Blog, we offer regular updates on delirium-related news, events and research through social media, our email listserve, and newsletters.
If you’re interested in contributing to NIDUS communications with a blog post, newsletter item, or social media post, contact us.
|
|
Delirium Measurement Info Cards
If you’ve ever used a delirium measurement tool, you might know that they vary considerably. Although there is a wide variety of instruments for screening, it can be difficult to choose the most appropriate tool for your practice or research.
In response, we created Delirium Info Cards (see sample below). These cards provide a standardized summary of commonly used delirium measurement tools to assess delirium. There are two Info Card collections for use in both ICU and non-ICU settings:
- Adult - Includes 34 assessment tools for delirium screening, diagnosis, or severity, and 5 brief screening tools
- Pediatric - Includes 5 pediatric delirium screening or diagnostic tools
|
|
These measurements come from a systematic review and a 2017 online survey*. As a result, they contain information from each instrument’s original validation study.
Not seeing what you need in this measurement list? Submit information about a delirium instrument by contacting us at nidus@hsl.harvard.edu.
*These info cards were created by the NIDUS Measurement and Harmonization Core (Leaders Richard N. Jones, ScD and Dale M. Needham, MD, PhD), funded by NIA R33AG071744, and are licensed under Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Under this license, anyone is free to share or adapt them cards for non-commercial purposes with proper attribution. Any adaptations must be shared using the same license.
|
|
Current Research Priority Areas
NIDUS is designed to help accelerate scientific discovery in the field of delirium. As a central program for all researchers interested in delirium, NIDUS provides resources for conducting research. Below are NIDUS' four Research Priority Areas:
- Inter-Relationship of Delirium and ADRD: studies on risk factors, pathophysiology, and treatment.
- Measurement of Delirium: Harmonization and refinement of measurement, with a goal towards unified assessment.
- Pathophysiology: Biomarker and mechanistic studies to advance our understanding and identify therapeutic targets.
- Clinical Trials: Intervention Development studies for future clinical trials, especially of treatments for delirium
|
|
NIDUS Published Papers
Measurement Core:
Helfand BKI, Detroyer E, Milisen K, Adamis D, Metzger ED, Boudreaux ED, Inouye SK, Jones RN. Harmonization of Four Delirium Instruments: Creating Crosswalks and the Delirium Item-Bank (DEL-IB). Am J Geriatr Psychiatry. 2021 Jul 29;. doi: 10.1016/j.jagp.2021.07.011. [Epub ahead of print]
Ancillary Studies:
Arias F, Alegria M, Kind AJ, Jones RN, Travison TG, Marcantonio ER, Schmitt EM, Fong TG, Inouye SK. A framework of social determinants of health for delirium tailored to older adults. J Am Geriatr Soc. 2021 Oct 25;. doi: 10.1111/jgs.17465. [Epub ahead of print]
Chan CK, Sieber FE, Blennow K,Inouye SK, Kahn G, Leoutsakos JS,Marcantonio ER, Neufeld KJ,Rosenberg PB, Wang NY, ZetterbergH, Lyketsos CG, Oh ES. Associationof Depressive Symptoms WithPostoperative Delirium and CSF Biomarkers for Alzheimer's DiseaseAmong Hip Fracture Patients. Am JGeriatr Psychiatry.2021Dec;29(12):1212-1221. doi:10.1016/j.jagp.2021.02.001. Epub2021 Feb 4. PubMed PMID:33640268. [Epub ahead of print]
Pilot Studies:
Boukrina O, Kowalczyk M, Koush Y, Kong Y, Barrett AM. Brain Network Dysfunction in Poststroke Delirium and Spatial Neglect: An fMRI Study. Stroke. 2021 Oct 8;:STROKEAHA121035733. doi: 10.1161/STROKEAHA.121.035733. [Epub ahead of print]
Reznik ME, Margolis SA, Mahta A, Wendell LC, Thompson BB, Stretz C, Rudolph JL, Boukrina O, Barrett AM, Daiello LA, Jones RN, Furie KL. Impact of Delirium on Outcomes After Intracerebral Hemorrhage. Stroke. 2021 Oct 5;:STROKEAHA120034023. doi: 10.1161/STROKEAHA.120.034023. [Epub ahead of print]
|
|
|
Join NIDUS!
About NIDUS
NIDUS is a collaborative research network dedicated to spurring innovation and new advances in delirium research through development of new research and measurement resources, training opportunities, pilot funding and dissemination of information. It is funded through an award from the National Institutes of Health/National Institute on Aging (grant no. R33AG071744).
|
|
|
|
|
