CITF-Funded Research Results
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Booster doses stimulate strong antibody responses, including in older adults
While two doses of COVID-19 vaccine can prevent serious illness in most cases, vaccine-induced immune responses decline naturally over time, which leads to an increased risk of breakthrough infections. A pre-print, not-yet peer-reviewed, from CITF-funded researchers Dr. Mark Brockman of Simon Fraser University, Dr. Zabrina Brumme of Simon Fraser University and the BC Centre for Excellence in HIV/AIDS, and Dr. Marc Romney, from Providence Health Care and the University of British Columbia, showed that a third (booster) dose of vaccine elevated both the levels of antibodies and their neutralizing capacity above that of two doses in all individuals, including older adults.
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Natural antibody wane reinforces importance of vaccination
In this month’s analysis, the CITF modelled the effect of waning antibodies, known as seroreversion, to account for the natural loss of antibodies that occurs through time. These calculations, based on the most recent research on time to antibody wane, found that as of November 30, 2021, an estimated 1 in 21 Canadians (4.7%) still had detectable antibodies due to a previous infection. The data were prior to widespread exposure to the Omicron variant. Notably, this estimate is lower than our previous month’s estimate of seroprevalence (7.8%), which did not incorporate seroreversion rates.
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Available Now: the January edition of the CITF Monthly Review
This month’s issue features:
- Expert commentary on how immunity to COVID-19 wanes over time, making booster vaccines essential;
- The latest CITF modeling & Canadian Blood Services data on immunity across Canada;
- SARS-CoV-2 in schools
- Vaccine safety
- More!
Read the complete magazine here
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The views expressed herein do not necessarily represent the views of the Public Health Agency of Canada.
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