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Dr. Di Wu recently published an article, titled "DCAF1 regulates Treg senescence via the ROS axis during immunological ageing"
Authors: Zengli Guo, Gang Wang, Bing Wu, Wei-Chun Chou, Liang Cheng, Chenlin Zhou, Jitong Lou, Di Wu, Lishan Su, Junnian Zheng, Jenny Pan-Yun Ting, and Yisong Y. Wan
Abstract: As a hallmark of immunological ageing, the low-grade, chronic inflammation with accumulation of effector-memory T cells contributes to the increased susceptibility of many ageing-related diseases. While the proinflammatory state of aged T cells indicates a dysregulation of immune homeostasis, whether and how ageing drives regulatory T (Treg) cell ageing and alters their function is not fully understood due to a lack of specific ageing markers. Here, by a combination of cellular, molecular and bioinformatic approaches, we discover that Treg cells senesce more severely than conventional T (Tconv) cells during ageing. We found Treg cells from aged mice were less efficient than young Treg cells to suppress Tconv cell function in an inflammatory-bowel-disease model and to prevent Tconv cell ageing in the irradiation-induced ageing model. Furthermore, we revealed that DCAF1 (DDB1 and CUL4 associated factor 1) was downregulated in aged Treg cells and was critical to restrain Treg cell ageing via glutathione S-transferase P (GSTP1) regulated reactive-oxygen-species (ROS). Importantly, interfering with GSTP1 and ROS pathways reinvigorated the proliferation and function of aged Treg cells. Therefore, our studies uncover an important role of DCAF1-GSTP1-ROS axis in Treg cell senescence, which leads to uncontrolled inflammation and immunological ageing. Read the full article here.
Dr. Di Wu recently gave an invited talk at Joint Statistical Meeting, talk titled "Gene set testing methods for single cell RNAseq (scRNAseq) data " in the Section on Statistics in Genomics and Genetics, supported by Biometrics Section, ENAR ( Eastern North American Region, International Biometric Society).
Dr. Lukasz Mazur and CHIP doctoral student Karthik Adapa recently published an article at BMJ Journals, titled "Electronic health records (EHR) simulation-based training: a scoping review protocol
Authors: Joseph K Nuamah, Karthik Adapa, Lukasz Mazur
Abstract Introduction: Effective electronic health record (EHR)-based training interventions facilitate improved EHR use for healthcare providers. One such training intervention is simulation-based training that emphasises learning actual tasks through experimentation in a risk-free environment without negative patient outcomes. EHR-specific simulation-based training can be employed to improve EHR use, thereby enhancing healthcare providers’ skills and behaviours. Despite the potential advantages of this type of training, no study has identified and mapped the available evidence. To fill that gap, this scoping review will synthesise the current state of literature on EHR simulation-based training. Read the full article here.
Congratulations Dr. Terika McCall! Terika McCall earns the first PhD in health informatics from Carolina - Read the article here
CHIP doctoral student, Michael Ortiz received two years’ worth of server costs from Amazon Web Services (Amazon Activate Founders Program) - http://academicsentinel.com/about
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Job Opportunities
Several part-time and full-time positions have been posted on the CHIP website
Job opportunities at AMIA Jobs
Job opportunities at NCHICA Career
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Events and Deadlines
How to enable AWS migration success, Thursday, August 27, 2PM ET, Register
Healthcare Analytics Summit 20 – September 1-3, learn more
IntelliSys 2020, Thu, 3 Sep 2020 - Fri, 4 Sep 2020, Registration coming soon
Future Health Summit 2020, Sep 23-24, Register
AHIMA20 Virtual Conference – October 14 – 17, learn more
AMIA 2020 Virtual Annual Symposium – November 14-18, learn more
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