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November 2, 2020

NYU Langone Self-Service De-Identified COVID-19 Dataset

The COVID-19 pandemic has spurred interest in research on the pathogen in the context of social determinants, clinical practices, treatment options, and outcomes. This has created an urgent need to make data about the care of patients affected by COVID available to researchers. Electronic health records offer a rich source of information for clinical research studies, hypothesis generation, cohort identification, and algorithm development. Many studies can work with de-identified data, which can substantially reduce regulatory hurdles.

At NYU Langone Health, we created a COVID-19 Dataset and made it available using the NYU Data Lake, our Hadoop big data platform. Our goal was to establish an institutional resource to democratize data, promote advanced analytics, and accelerate COVID research and innovation. The Data Lake provides a secure, flexible, scalable, integrated repository for self-service research data management and analysis. The resource enables users to re-identify patients (with appropriate regulatory approval) for enrollment in trials or other longitudinal studies, and provides the means to extend the data with other internal or external data sets in an agile and iterative manner.

The COVID-19 Dataset has been fully deployed, and continues to be improved iteratively. To date, over 150 NYU researchers, informaticists, and trainees have applied for use of the data, with about half accessing the database more than once. Reasons cited for use of the repository range over self-learning and exploratory research (“hope to identify vulnerable populations”), focused research (“explore impact of heart failure on COVID-19 outcomes”), preparation for interventional studies (“identify cohorts for trials”), and machine learning and predictive analytics (“patterns of COVID-19 disease manifestation/progression using machine learning”).

The COVID-19 Dataset prompted the design and delivery of an introductory clinical informatics training class for internal medical residents and researchers. The session described the Data Lake, its technical architecture, challenges encountered, key findings, and a demonstration of usage. The class will enhance curricula at our institution (masters, doctoral, and post-doctoral), and provide a foundation for a wide range of users to pursue research studies. Furthermore, this model of providing a disease specific curated de-identified dataset for use by NYULH researchers is expected to be replicable for other patient cohorts.

Top Stories

Doris Duke Physician Scientist Fellowship

The Doris Duke Charitable Foundation's Fund to Retain Clinical Scientists (FRCS) program at NYU Langone Health (NYULH) is an “extra hands” program that support our 250+ junior faculty who conduct human subjects research across NYULH's vast network of subsidiary institutions, including the NYU Grossman School of Medicine, five hospitals, emergency care locations, academic departments, and the Clinical and Translational Science Institute (CTSI). Grants up to $220,000 over two years will be awarded to physician scientists (MD, MD/PhD, DO, or foreign equivalent) in subspecialty fellowship training to support two years of clinical research that will strengthen their careers as biomedical investigators. Submission deadline is January 5, 2021, with award start date of July, 1 2021. The program seeks to support physician scientists in subspecialty fellowship to conduct an outstanding clinical research project, ensure research time protection to enable development of research skill, and facilitate strong mentor relationships. Click here to learn more about the program and application process. For questions, please contact Elana Lipschitz.

'Cite the CTSI' Webpage Now Live

The CTSI is excited to announce a new webpage and PDF dedicated to providing our investigators, trainees, and scholar clear language they can use when citing the CTSI in grants, publications, manuscripts, and other activities. Now live on the CTSI website, please view the new webpage here and be sure to print, download and/or share the PDF!

CONTAIN COVID-19 Supplement New Website Now Live

A new webpage dedicated to the Convalescent Plasma to Limit COVID-19 Complications in Hospitalized Patients (CONTAIN COVID-19) is now live on the CTSI website here. This randomized, blinded phase 2 adaptive trial will assess the efficacy and safety of anti-SARS-CoV-2 convalescent plasma in hospitalized patients with acute respiratory symptoms between 3 and 7 days after the onset of symptoms OR within 3 days of hospitalization. A total of 300 eligible subjects will be randomized in Stage 1 of the trial to a 1:1 ratio to receive either convalescent plasma from people who have recovered from Covid-2 containing antibodies to SARS-CoV-2 or control (saline solution). Subsequent Stages of the trial will be defined after conclusions from the previous Stage. Collaborators include National Center for Advancing Translational Science (NCATS), Albert Einstein College of Medicine, Yale University, The University of Texas Health Sciences Center at Houston, The University of Texas Health Science Center at Tyler, University of Miami, and Johns Hopkins University. New sites are being added on an ongoing bases.

Coming Soon:
A New Look for the NYU Data Catalog

This month the NYU Data Catalog will be getting a refreshed look. New items will include:
  • New and improved front page where you can get started with your search
  • A guide for using the Data Catalog and answers to frequently asked questions
  • Dataset access links and instructions that are easier to locate
  • NYU-generated and externally-collected datasets (e.g. census data) that are more distinguishable
The NYU Data Catalog is always growing! To learn more about how you can contribute your research, contact the team at datacatalog@nyulangone.org.

6th Annual Health Disparities Symposium Event Summary

From October 13-16, 2020, NYU Langone’s Section for Health Equity in the Department of Population Health hosted, in collaboration with NYU Langone’s Clinical and Translational Science Institute (CTSI), Office of Diversity Affairs, and the NYU-CUNY Prevention Research Center, its 6th annual Health Disparities Symposium. For the first time, this symposium offered Continuing Medical Education (CME) and Continuing Nursing Education (CNE) credits free of charge to all participants. Over 750 people registered for the symposium, with 585 unique attendees in total. The theme for this year's conference was turning "Research Into Action". As the COVID-19 pandemic unfolded, it highlighted continued structural racism faced by communities of color. One main takeaway from the conference is that now more than ever, it is essential that research addressing inequities in health be translatable and actionable.

The keynote address was given by Mary Bassett, former NYC Health Commissioner, and this year’s Controversies in Population Health Panel examined how the Public Charge Rule is exacerbating the public health crisis in immigrant communities. Other panel discussions included a CTSI Community Engagement Panel and the Role of Community Health Workers in Addressing Structural Racism. Speakers, moderators, and panelists from the Department of Population Health included Joseph RavenellNatasha WilliamsNadia IslamAzizi Seixas, and Alison Bateman-House. The agenda lists all speakers and talk topics from the event.

The symposium also featured 28 poster presentations, with awards given in the following categories:

Best Community-based Organization Research Poster

Gabriela Drucker, Institute of Human Nutrition, Columbia University Irving Medical Center & Nandini Kannan, MPH, Ambulatory Care Network, New York-Presbyterian. CBO collaborating partners: Mexican Coalition for the Empowerment of Youth & Families Inc., Nido de Esperanza NYC. “An effective clinical-community partnership model to address food insecurity in response to COVID-19”

Best Student Research Poster

Oyemwenosa Avenbuan, Department of Environmental Medicine, NYU Grossman School of Medicine. “Environmental Contamination and its Impact on a Native American Tribe”

Best Programmatic or Research Staff Research Poster

Chenyue Zhao, PhD, Department of Child and Adolescent Psychiatry, NYU Grossman School of Medicine. “Impacts of Prolonged Parent-Child Separation on the Well-Being of Chinese Immigrant Families: A Mixed-Methods Exploratory Study”

Best Post-Doctoral Fellow or Faculty Research Poster

Lan N. Ðoàn PhD, MPH, CPH, Department of Population Health, NYU Grossman School of Medicine. “Forging Partnerships for Rapid Response to COVID-19 to Support Asian American, Native Hawaiian and Pacific Islander Communities”


TREC Grand Rounds

The Translational Research Education and Careers (TREC) program will be hosting a virtual grand rounds session on November 18th at 4:00PM. The session will feature speaker Barry Crittenden, MD, MSCI who will speak about "A Translational Career in the Pharmaceutical Sector". Please use this Webex link to join the session and contact Claudia Galeano with any questions.

Center for Opioid Epidemiology & Policy Pilot Project Grant Program

The Center for Opioid Epidemiology and Policy at NYU Langone Health seeks applications from junior faculty and postdoctoral fellows within the NYU research community for our second round of Pilot Project Grant Funding.

This year, the pilot project grant program will focus on supporting work on racial/ethnic inequalities in the experience of the overdose crisis, its drivers, and potential solutions, as well as work on the impact of COVID-19 on substance use and misuse. Projects should focus on at least one of the focus areas below:
  • Describing racial/ethnic inequalities in the rates of opioid initiation, use, misuse, opioid use disorder, overdose, and consequences of use
  • Measuring the syndemic of opioid misuse with other psychosocial, social, and structural vulnerability factors among racial/ethnic minority groups
  • Examining the social, policy and structural drivers of racial/ethnic inequalities in the overdose epidemic and effects of the epidemic
  • Evaluating racial/ethnic inequalities in the impact of drug, treatment, social, and health policies on opioid-related harms
  • Evaluating promising approaches to address racial/ethnic inequalities in access to treatment for opioid use disorder
  • Evaluating the impact of COVID-19 on opioid use initiation, misuse, opioid use disorder, and overdose
  • Evaluating the impact of COVID-19 on policies that affect access to treatment for opioid use disorder
  • Describing how COVID-19 related events have affected stigmas related to drug use, racism, and access to social and medical programs for people who use drugs
Two awards of $10,000 are available. Applications are due on December 18, 2020 at 5:00 PM EST in REDCap.

The RFP is available for download below and on the application page here. Please share with your colleagues throughout NYU.

The Center for Opioid Epidemiology and Policy at NYU Langone Health serves as a central source of research on the United States’ rapidly shifting opioid overdose epidemic. COEP’s projects aim to inform evidence-based policies to prevent opioid misuse, disorder, and overdose in populations nationally and globally. Additional information is available on the COEP webpage.

Please direct questions to Caroline Barnes, MPH, senior project manager, at caroline.barnes@nyulangone.org.

In the Spotlight

Updated CTSI Consultation Request

Please click here to request CTSI Consultation Services if you are looking for valuable input on research protocols, biostatistics, recruitment, community population engagement, research expertise sessions (studio), and other services.

Translational Research in Progress Seminars

The Translational Research in Progress (TRIP) Seminars now take place every Monday and into 2021 via Zoom. For the webinar link or more information, please contact Shirley Cabrera at 212-263-2978.

Events

NOV
2
Translational Research in Progress (TRIP) Seminar
Featuring Artie Shen, PhD Student and Piul Rabbani, PhD
Date: November 2, 2020
Time: 12:00 PM - 1:00 PM
Location: Virtual (Zoom)
Contact: Shirley Cabrera for Zoom details
NOV
9
Translational Research in Progress (TRIP) Seminar
Featuring Speakers Ronaldo Hirata, DDS, MS, PhD and
Michael Wosczyna, PhD

Date: November 9, 2020
Time: 12:00 PM - 1:00 PM
Location: Virtual (Zoom)
Contact: Shirley Cabrera for Zoom details
NOV
16
Translational Research in Progress (TRIP) Seminar
Featuring Speakers Meike Dittmann, PhD and Ryan Fine, PhD
Date: November 16, 2020
Time: 12:00 PM - 1:00 PM
Location: Virtual (Zoom)
Contact: Shirley Cabrera for Zoom details
NOV
18
TREC Grand Rounds
Date: November 18, 2020
Time: 4:00 PM
Via Webex
NOV
30
Translational Research in Progress (TRIP) Seminar
Featuring Speakers Mathew Maurano, PhD and
Kevin Chuen Wing Chan, PhD

Date: November 30, 2020
Time: 12:00 PM - 1:00 PM
Location: Virtual (Zoom)
Contact: Shirley Cabrera for Zoom details
DEC
18
Deadline: Center for Opioid Epidemiology and & Policy Pilot Project Grant Program
Date: December 18, 2020
Time: 5:00 PM
Contact: Caroline Barnes
JAN
5
Physician Scientist Fellowship Submission Deadline
Date: January 5, 2021
Contact: Elana Lipschitz
More Information Here

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Check out the new COVID-19 CTSI Website

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