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Waging War on Metastatic Cancer


Fischell Institute researcher Xiaoming (Shawn) He (BIOE) and his team have dedicated years of tireless work to tackling two key questions: what causes cancer to metastasize,  and could strategically targeted therapies halt even the fastest-moving cancers? 

To address the former challenge, He and members of his lab teamed up with researchers from The Ohio State University, the University of Maryland’s Marlene and Stewart Greenebaum Comprehensive Cancer Center, and the University of Missouri School of Medicine to shed light on a prevailing theory that among the many types of cancer cells embedded within a malignant tumor are cancer cells that act as stem cells. 

He and his collaborators achieved a breakthrough discovery that supports the stem cell hypothesis. Last year, the team developed a novel technique to isolate a single cancer cell that fits the proverbial mold of a CSC. Inspired by nature’s own process – whereby a single cell proliferates into a cell colony in a miniaturized nanoliter core – He and his team created a miniaturized 3D microcapsule to encapsulate one single cancer cell in such a way that they could mimic the conditions under which stem cell colonies form from a single cell in an embryo. 
 

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M-CERSI Hosts 9th Annual Regulatory Science Competition


The University of Maryland Center of Regulatory Science and Innovation (M-CERSI) hosted its ninth annual “America’s Got Regulatory Science Talent” competition virtually on January 15. This competition aims to promote student interest in regulatory science – the science of developing new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of FDA-regulated products. Nine teams presented their innovative ideas to three FDA judges.

The first-place winners presented their idea for “PrescripChain,” a user-friendly mobile application for adverse event reporting that utilizes blockchain technology to provide automatic, bench-to-bedside tracing of the entirety of a drug’s lifespan. The first-, second-, and third-place winners will have the opportunity to present their ideas to the FDA's Office of the Chief Scientist.
 
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