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Introduction

Dear Colleagues and Friends of CIRC,
 

In March 2021, Dr. Udo Hoffman stepped down from his role as Director of the MGH Cardiovascular Imaging Research Center (CIRC). Udo joined CIRC (then the Cardiac MR PET CT Program) as faculty in 2003. He was named Director of CIRC in 2007, Chief of the MGH Division of Cardiac Imaging in 2011, and Professor of Radiology at Harvard Medical School in 2012.

It is hard to overstate Udo’s influence on our field. His tenure at CIRC produced foundational advances in how coronary CT angiography (CTA) is used in research and clinical practice. He was PI of ROMICAT-I/ROMICAT-II (Hoffmann NEJM 2012) and PI of the Diagnostic Core of PROMISE (Douglas & Hoffmann NEJM 2015), landmark trials that established coronary CTA as an effective diagnostic tool in acute and stable chest pain. He led the CT core laboratory for the Framingham Heart Study, which yielded important insights into the epidemiology of body fat and coronary artery calcium. As Co-PI of REPRIEVE, he helped establish CIRC as a leader in characterizing changes in coronary plaque on CT. As PI and Co-PI of CIRC’s T32 fellowship program, he trained a generation of cardiovascular imagers and researchers.

Udo is a mentor to many of us at CIRC, and to many of the leaders in cardiovascular imaging across the world. He will be sorely missed. We wish him and his family the best on his next chapter.

 

Sincerely,
 

Michael Lu, Tom Neilan, Ahmed Tawakol

Co-Directors of the MGH Cardiovascular Imaging Research Center (CIRC)
 

Borek Foldyna

Associate Director of Operations, CIRC
Awards and Contracts
The PIAF Trial on Arterial 18F-FDG PET Imaging in Patients with History of Myocardial Infarction and Elevated Inflammatory Status
 
Dr. Ahmed Tawakol
Sponsor: International Atomic Energy Agency

Major Goals: 1) Define distinct arterial FDG thresholds, which identify patients at risk for an emerging severe cardio-cerebrovascular event (i.e., acute coronary syndrome, non-fatal ischaemic stroke, ischaemic cardiac death), using non-invasive PET/CT imaging. Further events, such as coronary/vascular revascularization, new-onset of angina, symptomatic peripheral arterial disease, and heart failure, will be recorded as secondary endpoints. 2) Specify the clinical application of PET/CT imaging to identify patients with inflammatory atherosclerosis who are at increased risk for cardiovascular events and to develop novel diagnostic algorithms in combination with biomarkers and clinical protocols accordingly. By stratifying the risk for emerging CV events, the project will contribute to fulfilling Sustainable Development Goal (SDG) 3.4 to reduce mortality associated with NCD 30% by 2030.
Research Highlights

 
Dr. Júlia Karády
 
"Discordance of High-Sensitivity Troponin Assays in Patients With Suspected Acute Coronary Syndromes" JACC 2021
 
The concordance of three high-sensitivity troponin (hs-cTn) assays that were recently cleared by the FDA (Elecsys2010, Roche Diagnostics; ARCHITECT i2000SR, Abbott Diagnostics; hsVista, Siemens Diagnostics) is unknown. In the ROMICAT I and II cohort of patients with suspected acute coronary syndrome, the three hs-cTn assays classified blood samples into the same analytical benchmark category in 37.4% of samples (384/1,027), when 1-timepoint troponin measurement was used. In 242 patients for whom serial troponin testing was available, the assays agreed to recommend similar management in 74.8%. Overall, the results of this analysis suggest that clinicians should be aware that the discordance between these hs-cTn assays is significant enough that management recommendations may change for certain patients (e.g. a patient who is transferred from one hospital to another using different hs-cTn assays).

Link to paper: https://doi.org/10.1016/j.jacc.2021.01.046

Dr. Karády discussed this article during two interviews. 
1) Medscape: https://www.medscape.com/viewarticle/947899
2) TCTMD: https://www.tctmd.com/news/watch-out-differences-among-high-sensitivity-troponin-assays 

Dr. Roman Zeleznik
 
“Deep Convolutional Neural Networks to Predict Cardiovascular Risk From Computed Tomography” Nature Communications 2021

Coronary artery calcification is an important predictor of adverse cardiovascular events, like heart attacks, which can be detected by computed tomography (CT) scans. However, quantifying the amount of plaque requires radiological expertise, time, and specialized equipment. Although chest CT scans are fairly common in practice, calcium score CTs are not. Investigators from Brigham and Women’s Hospital’s Artificial Intelligence in Medicine (AIM) Program and CIRC teamed up to develop and evaluate a deep learning system that may help change this. 

The deep learning system, which was trained on data from the Framingham Heart Study (FHS), follows the workflow of human expert readers to automatically measure and quantify coronary artery calcium from CT scans to help physicians and patients make more informed decisions about cardiovascular prevention. The system was also applied to three additional study cohorts; 1) heavy smokers undergoing lung cancer screening CT (NLST: National Lung Screening Trial), 2) patients with stable chest pain undergoing cardiac CT (PROMISE: the Prospective Multicenter Imaging Study for Evaluation of Chest Pain), and 3) patients with acute chest pain undergoing cardiac CT (ROMICAT-II: the Rule Out Myocardial Infarction using Computer Assisted Tomography trial).

One of the unique aspects of this study is the inclusion of these three high-quality NHLBI–funded image and outcome trials, which strengthened the generalizability of these results to clinical settings. In total, the deep learning system was validated in over 20,000 individuals. The automated calcium scores from the system highly correlated with the manual calcium scores from human experts and were able to predict major adverse cardiovascular events like heart attacks. 

Link to paper: https://www.nature.com/articles/s41467-021-20966-2

 
Dr. Daniel Zlotoff
 
"Electrocardiographic Features of Immune Checkpoint Inhibitor Associated Myocarditis" Journal for ImmunoTherapy of Cancer 2021
 
Immune checkpoint inhibitors (ICIs) are a type of cancer therapy that can cause various cardiovascular adverse effects, including myocarditis. Zlotoff and colleagues in Tom Neilan's research group examined the electrocardiographic features of ICI-associated myocarditis. The QRS duration was unaffected by ICI therapy alone but was prolonged at the time of myocarditis. A prolonged QRS duration (>110 ms) was associated with an increased rate of major cardiac events in univariable and multivariable analyses. These findings may aid in the diagnosis and risk-stratification of ICI-associated myocarditis.

Link to paper: http://dx.doi.org/10.1136/jitc-2020-002007

 
Dr. Zsofia Drobni
 
"Myocardial T1 and T2 Mapping by Magnetic Resonance in Patients With Immune Checkpoint Inhibitor-Associated Myocarditis" JACC 2021
 
In an international registry of 136 patients with immune checkpoint inhibitor-associated myocarditis and a cardiac MR study, we found that when applying the modified Lake Louise Criteria, 95% met the nonischemic myocardial injury criteria and 53% met the myocardial edema criteria. Moreover, native T1 values, but not T2 values, were independently associated with subsequent major adverse cardiovascular events. The use of T1 mapping and the application of the modified Lake Louise Criteria provides important diagnostic value, and T1 mapping provides prognostic value in patients with ICI myocarditis.

Link to paper: https://doi.org/10.1016/j.jacc.2021.01.050

 
Dr. Vineet Raghu
 
"Deep Learning to Estimate Biological Age From Chest Radiographs" JACC Cardiovasc Imaging 2021
 
Chronological age is a cornerstone of medical-decision making; however, it is an imperfect measure of health and aging as individuals age at different rates. Biological age, a number in years reflecting overall health, has been proposed as a better measure of susceptibility to aging-related disease. Our study proposed a novel measure of biological age based on deep learning analysis of a chest radiograph (chest x-ray age or CXR-Age). CXR-Age was developed using radiographs from over 110,000 individuals from two multi-center cancer screening trials and tested in two independent datasets of 40,000 and 5,000 individuals. We found that CXR-Age predicted all-cause and cardiovascular mortality better than chronological age and had added value beyond prevalent risk factors, chronological age, and documented findings from radiologists’ interpretation of the radiograph.

Link to paper: https://pubmed.ncbi.nlm.nih.gov/33744131/

 
Dr. Amna Zafar
 
"The Incidence, Risk Factors, and Outcomes With 5-Fluorouracil-Associated Coronary Vasospasm" JACC CardioOncol 2021
 
Coronary vasospasm is a recognized side effect of 5-FU (fluorouracil) therapy. We compared patients who developed vasospasm while on 5-FU therapy to patients who did not develop vasospasm while on 5-FU in a 1:2 ratio. Among 4019 patients who received 5-FU between 2009 and 2019 at MGH, 87 (2.16%) developed vasospasm. Patients who developed vasospasm were younger, had lower rates of traditional cardiovascular risk factors, and had no significant difference in progression-free or overall survival compared to those who did not develop vasospasm.

Link to paper: https://pubmed.ncbi.nlm.nih.gov/33817666/
Promotions
Congratulations to Yuji Liao! 
 
Yuji is now the Administrative Manager for CIRC. She will provide administrative leadership to CIRC by overseeing the research grants and contract administration, and providing direct supervision to grant management and administrative support staff. Yuji has been a valuable member of CIRC for over four years. She first joined as a grant administrator in 2016 and was promoted to a senior grant administrator in 2018. Under her supervision, the research portfolio of CIRC has grown from $3M in FY17 to >$8M in FY21.
Welcome New Members!
Dr. Charbel Gharios is a Research Fellow joining Dr. Tawakol's lab.

Dr. Gharios obtained his MD degree from the American University of Beirut in 2020. After graduation, he pursued an NIH-funded clinical research certificate to acquire the necessary quantitative skills to analyze large clinical datasets. He wishes to use molecular imaging data to better understand the social, genetic, and psychological determinants that contribute to cardiovascular risk.
Kayla Paradis joins us as a Project/Program Manager for the REPRIEVE Trial.

She completed her BS in Biology and Chemistry at Worcester State University and is currently working toward her MBA. Her prior experience includes working as a Research and Development Scientist for coagulation in-vitro diagnostic medical devices (IVDs).
Farewell
Parastou Eslami

Dr. Parastou Eslami joined CIRC in 2016, as a T-32 postdoctoral fellow, upon finishing her PhD in computational fluid dynamics at Johns Hopkins University. During her tenure with the group she worked on various clinical datasets including the Framingham Heart Study, PROMISE, REPRIEVE, and HIV Statin. She became a junior faculty at CIRC in August 2019 as an Instructor of Radiology. Parastou worked on computational method development of coronary hemodynamics based on coronary CTA and has published fundamental papers in proving coronary CTA can capture the same detailed hemodynamics as intravascular imaging. Her studies showed that coronary wall elasticity is negligible in calculating time averaged wall shear stress distribution in the coronaries. Parastou was also involved in machine learning projects such as radiomics of coronary calcium in the Framingham Heart Study, deep learning based heart, and coronary calcium segmentations. Additionally, she assisted other researchers with data curation and setting up measurements.

Parastou will be joining Philips as a “Senior Clinical Data Scientist” working with clinical sites such as Mt. Sinai and MGH, to facilitate image-based research projects focusing on cardiovascular diseases.




 
New Publications

Abohashem S, Osborne MT, Dar T, Naddaf N, Abbasi T, Ghoneem A, Radfar A, Patrich T, Oberfeld B, Tung B, Fayad ZA, Rajagopalan S, Tawakol A. A leucopoietic-arterial axis underlying the link between ambient air pollution and cardiovascular disease in humans. Eur Heart J. 2021 Feb 14;42(7):761-772. doi: 10.1093/eurheartj/ehaa982. PMID: 33428721; PMCID: PMC7882372.

Atkins KM, Bitterman DS, Chaunzwa TL, Williams CL, Rahman R, Kozono DE, Baldini EH, Aerts HJWL, Tamarappoo BK, Hoffmann U, Nohria A, Mak RH. Statin Use, Heart Radiation Dose, and Survival in Locally Advanced Lung Cancer. Pract Radiat Oncol. 2021 Jan 18:S1879-8500(21)00002-3. doi: 10.1016/j.prro.2020.12.006. Epub ahead of print. PMID: 33476841.

Atkins KM, Chaunzwa TL, Lamba N, Bitterman DS, Rawal B, Bredfeldt J, Williams CL, Kozono DE, Baldini EH, Nohria A, Hoffmann U, Aerts HJWL, Mak RH. Association of Left Anterior Descending Coronary Artery Radiation Dose With Major Adverse Cardiac Events and Mortality in Patients With Non-Small Cell Lung Cancer. JAMA Oncol. 2021 Feb 1;7(2):206-219. doi: 10.1001/jamaoncol.2020.6332. PMID: 33331883; PMCID: PMC7747040.

Bang V, Ganatra S, Shah SP, Dani SS, Neilan TG, Thavendiranathan P, Resnic FS, Piemonte TC, Barac A, Patel R, Sharma A, Parikh R, Chaudhry GM, Vesely M, Hayek SS, Leja M, Venesy D, Patten R, Lenihan D, Nohria A, Cooper LT. Management of Patients With Giant Cell Myocarditis: JACC Review Topic of the Week. J Am Coll Cardiol. 2021 Mar 2;77(8):1122-1134. doi: 10.1016/j.jacc.2020.11.074. PMID: 33632487.

Elgendy IY, Kolte D, Mansour MK, Sakhuja R, Elmariah S, Jaffer FA, Neilan TG, Januzzi JL, Weinberg I, Albaghdadi MS. Incidence, Predictors, and Outcomes of Thrombotic Events in Hospitalized Patients With Viral Pneumonia. Am J Cardiol. 2021 Mar 15;143:164-165. doi: 10.1016/j.amjcard.2021.01.001. Epub 2021 Jan 14. PMID: 33453170; PMCID: PMC7807171.

Foldyna B, Zeleznik R, Eslami P, Mayrhofer T, Scholtz JE, Ferencik M, Bittner DO, Meyersohn NM, Puchner SB, Emami H, Pellikka PA, Aerts HJWL, Douglas PS, Lu MT, Hoffmann U. Small whole heart volume predicts cardiovascular events in patients with stable chest pain: insights from the PROMISE trial. Eur Radiol. 2021 Jan 26. doi: 10.1007/s00330-021-07695-2. Epub ahead of print. PMID: 33501599.
Giles JT, Rist PM, Liao KP, Tawakol A, Fayad ZA, Mani V, Paynter NP, Ridker PM, Glynn RJ, Lu F, Broderick R, Murray M, Vanni KMM, Solomon DH, Bathon JM. Testing the Effects of Disease-Modifying Antirheumatic Drugs on Vascular Inflammation in Rheumatoid Arthritis: Rationale and Design of the TARGET Trial. ACR Open Rheumatol. 2021 May 1. doi: 10.1002/acr2.11256. Epub ahead of print. PMID: 33932148.

Kammerlander AA, Lyass A, Mahoney TF, Massaro JM, Long MT, Vasan RS, Hoffmann U. Sex Differences in the Associations of Visceral Adipose Tissue and Cardiometabolic and Cardiovascular Disease Risk: The Framingham Heart Study. J Am Heart Assoc. 2021 May 15:e019968. doi: 10.1161/JAHA.120.019968. Epub ahead of print. PMID: 33998254.
Kammerlander AA, Mayrhofer T, Ferencik M, Pagidipati NJ, Karady J, Ginsburg GS, Lu MT, Bittner DO, Puchner SB, Bihlmeyer NA, Meyersohn NM, Emami H, Shah SH, Douglas PS, Hoffmann U; PROMISE Investigators. Association of Metabolic Phenotypes With Coronary Artery Disease and Cardiovascular Events in Patients With Stable Chest Pain. Diabetes Care. 2021 Apr;44(4):1038-1045. doi: 10.2337/dc20-1760. Epub 2021 Feb 8. PMID: 33558267; PMCID: PMC7985425.

Karády J, Mayrhofer T, Ferencik M, Nagurney JT, Udelson JE, Kammerlander AA, Fleg JL, Peacock WF, Januzzi JL Jr, Koenig W, Hoffmann U. Discordance of High- Sensitivity Troponin Assays in Patients With Suspected Acute Coronary Syndromes. J Am Coll Cardiol. 2021 Mar 30;77(12):1487-1499. doi: 10.1016/j.jacc.2021.01.046. PMID: 33766254; PMCID: PMC8040768.
Kessinger CW, Qi G, Hassan MZO, Henke PK, Tawakol A, Jaffer FA. Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging Predicts Vein Wall Scarring and Statin Benefit in Murine Venous Thrombosis. Circ Cardiovasc Imaging. 2021 Mar;14(3):e011898. doi: 10.1161/CIRCIMAGING.120.011898. Epub 2021 Mar 16. PMID: 33724049.

Li W, Kessinger CW, Orii M, Lee H, Wang L, Weinberg I, Jaff MR, Reed GL, Libby P, Tawakol A, Henke PK, Jaffer FA. Time-Restricted Salutary Effects of Blood Flow Restoration on Venous Thrombosis and Vein Wall Injury in Mouse and Human Subjects. Circulation. 2021 Mar 23;143(12):1224-1238. doi: 10.1161/CIRCULATIONAHA.120.049096. Epub 2021 Jan 15. PMID: 33445952; PMCID: PMC7988304.
Maus MV, Alexander S, Bishop MR, Brudno JN, Callahan C, Davila ML, Diamonte C, Dietrich J, Fitzgerald JC, Frigault MJ, Fry TJ, Holter-Chakrabarty JL, Komanduri KV, Lee DW, Locke FL, Maude SL, McCarthy PL, Mead E, Neelapu SS, Neilan TG, Santomasso BD, Shpall EJ, Teachey DT, Turtle CJ, Whitehead T, Grupp SA. Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune effector cell-related adverse events. J Immunother Cancer. 2020 Dec;8(2):e001511. doi: 10.1136/jitc-2020-001511. PMID: 33335028; PMCID: PMC7745688.

Molina GE, Zubiri L, Cohen JV, Durbin SM, Petrillo L, Allen IM, Murciano- Goroff YR, Dougan M, Thomas MF, Faje AT, Rengarajan M, Guidon AC, Chen ST, Okin D, Medoff BD, Nasrallah M, Kohler MJ, Schoenfeld SR, Karp Leaf RS, Sise ME, Neilan TG, Zlotoff DA, Farmer JR, Mooradian MJ, Bardia A, Mai M, Sullivan RJ, Semenov YR, Villani AC, Reynolds KL. Temporal Trends and Outcomes Among Patients Admitted for Immune-Related Adverse Events: A Single-Center Retrospective Cohort Study from 2011 to 2018. Oncologist. 2021 Mar 3. doi: 10.1002/onco.13740. Epub ahead of print. PMID: 33655682.
Osborne MT, Abbasi TA, Zureigat H, Tawakol A. A vessel of progress: Aortic microcalcification activity for the quantification of 18F-NaF uptake in the thoracic aorta. J Nucl Cardiol. 2021 Feb 22. doi: 10.1007/s12350-021-02557-2. Epub ahead of print. PMID: 33619634.

Powell-Wiley TM, Dey AK, Rivers JP, Chaturvedi A, Andrews MR, Ceasar JN, Claudel SE, Mitchell VM, Ayers C, Tamura K, Gutierrez-Huerta CA, Teague HL, Oeser SG, Goyal A, Joshi AA, Collins BS, Baumer Y, Chung ST, Sumner AE, Playford MP, Tawakol A, Mehta NN. Chronic Stress-Related Neural Activity Associates With Subclinical Cardiovascular Disease in a Community-Based Cohort: Data From the Washington, D.C. Cardiovascular Health and Needs Assessment. Front Cardiovasc Med. 2021 Mar 10;8:599341. doi: 10.3389/fcvm.2021.599341. PMID: 33778019; PMCID: PMC7988194.
Radbruch A, McGrath MA, Siracusa F, Hoffmann U, Sercan-Alp Ö, Hutloff A, Tokoyoda K, Chang HD, Dong J. Homeostasis and Durability of T-Cell Memory-The Resting and the Restless T-Cell Memory. Cold Spring Harb Perspect Biol. 2021 Apr 26:a038083. doi: 10.1101/cshperspect.a038083. Epub ahead of print. PMID: 33903153.

Radfar A, Abohashem S, Osborne MT, Wang Y, Dar T, Hassan MZO, Ghoneem A, Naddaf N, Patrich T, Abbasi T, Zureigat H, Jaffer J, Ghazi P, Scott JA, Shin LM, Pitman RK, Neilan TG, Wood MJ, Tawakol A. Stress-associated neurobiological activity associates with the risk for and timing of subsequent Takotsubo syndrome. Eur Heart J. 2021 May 14;42(19):1898-1908. doi: 10.1093/eurheartj/ehab029. PMID: 33768230.

Raghu VK, Weiss J, Hoffmann U, Aerts HJWL, Lu MT. Deep Learning to Estimate Biological Age From Chest Radiographs. JACC Cardiovasc Imaging. 2021 Mar 10:S1936-878X(21)00068-1. doi: 10.1016/j.jcmg.2021.01.008. Epub ahead of print. PMID: 33744131.

Samei E, Richards T, Segars WP, Daubert MA, Ivanov A, Rubin GD, Douglas PS, Hoffmann U. Task-dependent estimability index to assess the quality of cardiac computed tomography angiography for quantifying coronary stenosis. J Med Imaging (Bellingham). 2021 Jan;8(1):013501. doi: 10.1117/1.JMI.8.1.013501. Epub 2021 Jan 9. PMID: 33447644; PMCID: PMC7797007.

Suero-Abreu GA, Ganatra S, Neilan TG. Cardiotoxicity Monitoring in Patients With Cancer: Focus on Safety and Clinical Relevance. JCO Oncol Pract. 2021 May;17(5):237-239. doi: 10.1200/OP.21.00075. Epub 2021 Apr 1. PMID: 33793304.
Takazaki KAG, Quinaglia T, Venancio TD, Martinez ARM, Shah RV, Neilan TG, Jerosch-Herold M, Coelho-Filho OR, França MC Jr. Pre-clinical left ventricular myocardial remodeling in patients with Friedreich's ataxia: A cardiac MRI study. PLoS One. 2021 Mar 26;16(3):e0246633. doi: 10.1371/journal.pone.0246633. PMID: 33770103; PMCID: PMC7996973.
Takigami, A.K., Ghoshhajra, B. & Hedgire, S. The Role of Cardiac Computed Tomography in Valve Disease and Valve Intervention Planning. Curr Treat Options Cardio Med 23, 3 (2021). https://doi.org/10.1007/s11936-020-00879-x

Taron J, Foldyna B, Mayrhofer T, Osborne MT, Meyersohn N, Bittner DO, Puchner SB, Emami H, Lu MT, Ferencik M, Pagidipati NJ, Douglas PS, Hoffmann U. Risk Stratification With the Use of Coronary Computed Tomographic Angiography in Patients With Nonobstructive Coronary Artery Disease. JACC Cardiovasc Imaging. 2021 Apr 8:S1936-878X(21)00285-0. doi: 10.1016/j.jcmg.2021.03.019. Epub ahead of print. PMID: 33865792.
Taron J, Lyass A, Mahoney TF, Ehrbar RQ, Vasan RS, D'Agostino RB Sr, Hoffmann U, Massaro JM, Lu MT. Coronary Artery Calcium Score-Directed Primary Prevention With Statins on the Basis of the 2018 American College of Cardiology/American Heart Association/Multisociety Cholesterol Guidelines. J Am Heart Assoc. 2021 Jan 5;10(1):e018342. doi: 10.1161/JAHA.120.018342. Epub 2020 Dec 22. PMID: 33348999; PMCID: PMC7955488.

Tawakol A, Abraham SA, Gregory SA, Osborne MJ, Palmer EL, Spooner AE, Zervos GD, Scott JA. Henry Gewirtz, MD (1945-2021). J Nucl Cardiol. 2021 May 12. doi: 10.1007/s12350-021-02657-z. Epub ahead of print. PMID: 33982203.

Thavendiranathan P, Zhang L, Zafar A, Drobni ZD, Mahmood SS, Cabral M, Awadalla M, Nohria A, Zlotoff DA, Thuny F, Heinzerling LM, Barac A, Sullivan RJ, Chen CL, Gupta D, Kirchberger MC, Hartmann SE, Weinsaft JW, Gilman HK, Rizvi MA, Kovacina B, Michel C, Sahni G, González-Mansilla A, Calles A, Fernández-Avilés F, Mahmoudi M, Reynolds KL, Ganatra S, Gavira JJ, González NS, García de Yébenes Castro M, Kwong RY, Jerosch-Herold M, Coelho-Filho OR, Afilalo J, Zataraín- Nicolás E, Baksi AJ, Wintersperger BJ, Calvillo-Arguelles O, Ederhy S, Yang EH, Lyon AR, Fradley MG, Neilan TG. Myocardial T1 and T2 Mapping by Magnetic Resonance in Patients With Immune Checkpoint Inhibitor-Associated Myocarditis. J Am Coll Cardiol. 2021 Mar 30;77(12):1503-1516. doi: 10.1016/j.jacc.2021.01.050. PMID: 33766256.

Toribio M, Fulda ES, Chu SM, Drobni ZD, Awadalla M, Cetlin M, Stanley TL, North CM, Nelson MD, Jerosch-Herold M, Szczepaniak LS, Burdo TH, Looby SE, Neilan TG, Zanni MV. Hot Flashes and Cardiovascular Disease Risk Indices Among Women With HIV. Open Forum Infect Dis. 2021 Jan 12;8(2):ofab011. doi: 10.1093/ofid/ofab011. PMID: 33575428; PMCID: PMC7863866.

Totzeck M, Lutgens E, Neilan TG. Are we underestimating the potential for cardiotoxicity related to immune checkpoint inhibitors? Eur Heart J. 2021 Apr 21;42(16):1632-1635. doi: 10.1093/eurheartj/ehaa959. PMID: 33291139; PMCID: PMC8088813.

Van Dyke TE, Kholy KE, Ishai A, Takx RAP, Mezue K, Abohashem SM, Ali A, Yuan N, Hsue P, Osborne MT, Tawakol A. Inflammation of the periodontium associates with risk of future cardiovascular events. J Periodontol. 2021 Mar;92(3):348-358. doi: 10.1002/JPER.19-0441. Epub 2021 Feb 13. PMID: 33512014; PMCID: PMC8080258.

Zafar A, Drobni ZD, Mosarla R, Alvi RM, Lei M, Lou UY, Raghu VK, Murphy SP, Jones-O'Connor M, Hartmann S, Gilman HK, Weekes CD, Clark JR, Clark J, Blaszkowsky L, Tavares E, Neilan TG. The Incidence, Risk Factors, and Outcomes With 5-Fluorouracil-Associated Coronary Vasospasm. JACC CardioOncol. 2021 Mar;3(1):101-109. doi: 10.1016/j.jaccao.2020.12.005. Epub 2021 Mar 16. PMID: 33817666; PMCID: PMC8018593.

Zeleznik R, Foldyna B, Eslami P, Weiss J, Alexander I, Taron J, Parmar C, Alvi RM, Banerji D, Uno M, Kikuchi Y, Karady J, Zhang L, Scholtz JE, Mayrhofer T, Lyass A, Mahoney TF, Massaro JM, Vasan RS, Douglas PS, Hoffmann U, Lu MT, Aerts HJWL. Deep convolutional neural networks to predict cardiovascular risk from computed tomography. Nat Commun. 2021 Jan 29;12(1):715. doi: 10.1038/s41467-021-20966-2. PMID: 33514711; PMCID: PMC7846726.
Zeleznik R, Weiss J, Taron J, Guthier C, Bitterman DS, Hancox C, Kann BH, Kim DW, Punglia RS, Bredfeldt J, Foldyna B, Eslami P, Lu MT, Hoffmann U, Mak R, Aerts HJWL. Deep-learning system to improve the quality and efficiency of volumetric heart segmentation for breast cancer. NPJ Digit Med. 2021 Mar 5;4(1):43. doi: 10.1038/s41746-021-00416-5. PMID: 33674717; PMCID: PMC7935874.

Zhang L, Abohashem S, Osborne MT, Naddaf N, Park R, Moore K Jr, Patrich T, Deeks SG, Hsue PY, Tawakol AA. Brief Report: Lower Socioeconomic Status Associates With Greater Systemic and Arterial Inflammation in HIV. J Acquir Immune Defic Syndr. 2021 May 1;87(1):706-710. doi: 10.1097/QAI.0000000000002630. PMID: 33492022; PMCID: PMC8026700.

Zhang L, Reynolds KL, Lyon AR, Palaskas N, Neilan TG. The Evolving Immunotherapy Landscape and the Epidemiology, Diagnosis, and Management of Cardiotoxicity: JACC: CardioOncology Primer. JACC CardioOncol. 2021 Mar;3(1):35-47. doi: 10.1016/j.jaccao.2020.11.012. Epub 2021 Jan 12. PMID: 33842895; PMCID: PMC8034586.
Zlotoff DA, Hassan MZO, Zafar A, Alvi RM, Awadalla M, Mahmood SS, Zhang L, Chen CL, Ederhy S, Barac A, Banerji D, Jones-O'Connor M, Murphy SP, Armanious M, Forrestal BJ, Kirchberger MC, Coelho-Filho OR, Rizvi MA, Sahni G, Mandawat A, Tocchetti CG, Hartmann S, Gilman HK, Zatarain-Nicolás E, Mahmoudi M, Gupta D, Sullivan R, Ganatra S, Yang EH, Heinzerling LM, Thuny F, Zubiri L, Reynolds KL, Cohen JV, Lyon AR, Groarke J, Thavendiranathan P, Nohria A, Fradley MG, Neilan TG. Electrocardiographic features of immune checkpoint inhibitor associated myocarditis. J Immunother Cancer. 2021 Mar;9(3):e002007. doi: 10.1136/jitc-2020-002007. PMID: 33653803; PMCID: PMC7929895.

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Cardiac MR PET CT Program at Massachusetts General Hospital and Harvard Medical School · 165 Cambridge St. Ste. 400 · Boston, Ma 02114 · USA