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18th December 2023

Welcome to our second Lancefield Society Newsletter 

We are pleased to share this second Lancefield Society Newsletter with our members. There has been a great deal of activity in the streptococcal research field since our last newsletter. Below we announce the establishment of our Early Career Researcher Network Committee, provide some information on the location of the 2025 LISSSD meeting, and highlight new initiatives and research. We hope you enjoy the newsletter and please provide us with feedback as we work to strengthen the role of the Lancefield Society to support the streptococcal research community. 

Lancefield Society Early Career Researcher Network Committee

We are very pleased to announce the selection of our Early Career Researcher Network Committee. This network will consist of post-doctoral researchers (within approximately 10 years of PhD completion) working in the field of streptococci and streptococcal diseases. The Society will provide support for the Committee to organise webinars and identify speakers of interest. Please join us in welcoming and celebrating our new Committee!
Countdown to LISSSD 2025 – What Brisbane has to Offer!
 
The Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD) will take place in Brisbane, Australia in 2025. The event will occur from the 1st to the 5th June, and will provide a global platform, shining the spotlight on Australia, leading the world in Streptococcal research and clinical application for infection. 
Co-chairs of the symposium are Professor Michael Good and Associate Professor Manisha Pandey, both from Griffith University’s Institute for Glycomics in Brisbane. Professor Good and Associate Professor Pandey have studied streptococcal immunity and developed vaccine platforms and candidate peptide-based vaccines, currently in clinical trials.

As a nation, Australia is deeply impacted by streptococcal diseases with the country’s Indigenous population recording the highest rates of rheumatic heart disease in the world. 

Professor Good says the world needs a vaccine more than ever. “There has been a five-fold increase in strep cases globally in the last two years and if our vaccine proves effective, we believe it has the ability to halt/slow the pandemic, particularly in remote overcrowded communities which have a lack of primary treatment and care.” 

Associate Professor Pandey said “hosting the conference in Australia will not only provide a platform to showcase the extensive research in this field, but also shine a spotlight on the impacts this disease is having across Australia to generate a call to action for international collaboration for global solutions in this field”.

It is anticipated some 500 scientists, clinicians and health care professionals engaged in the field of streptococci and streptococcal diseases research from around the globe will attend the Symposium in June 2025 in Brisbane, the capital of the State of Queensland and currently enjoying the fastest growth among Australia’s major cities. Brisbane is also one of the world’s greenest cities, having recently attained gold level under the United Nations’ (UN) Sustainable Development Goals Cities Global Initiative. 
Launch of SAVAC 2.0

The Strep A Vaccine Global Consortium (SAVAC 2.0) was officially launched in Abu Dhabi, United Arab Emirates on 1st November 2023, in front of a diverse audience, that included members of the Strep A vaccine research community, funders and other key stakeholders. The launch occurred in tandem with the World Congress on Rheumatic Heart Disease, held 2nd and 4th November 2023 in Abu Dhabi. 
SAVAC 2.0 is led by co-Chairs Dr. Jerome Kim (Director General of the International Vaccine Institute in Seoul) and Prof. Andrew Steer (Director of Infection, Immunity and Global Health at the Murdoch Children’s Research Institute in Melbourne). SAVAC 1.0 identified knowledge gaps, barriers and blocking points for Strep A vaccine development. SAVAC 2.0, with the support of the Leducq Foundation and Open Philanthropy, endeavours to address these knowledge gaps and barriers. SAVAC 2.0 proposes to accelerate Strep A vaccine development by preparing for vaccine trials, engaging with industry and non-industry stakeholders and tacking important questions around Strep A vaccine safety.
World Congress on Rheumatic Heart Disease 

Global experts in the field of rheumatic heart disease gathered in Abu Dhabi between the 2nd and 4th November 2023 for the World Congress on Rheumatic Heart Disease. The Congress ran in four tracks: 
         1. Strep A Vaccines
      2. Pathogenesis & Other Biological Insights
      3. Clinical Presentation & Contemporary Management
      4. Tertiary Care & Surgery
The Congress was an excellent opportunity for researchers, of both rheumatic heart disease and associated fields, to connect and collaborate. 
Research spotlight: Streptococcus pyogenes research in The Gambia

Since 2018, a growing group of researchers at The Medical Research Council (MRC) Unit The Gambia and the London School of Hygiene and Tropical Medicine (LSHTM) have been working on Streptococcus pyogenes disease burden and immune responses to natural infection. Several studies that have significantly advanced our understanding of S. pyogenes have been conducted. 

The SpyCATS household cohort study followed 442 individuals from 44 households and yielded exciting results regarding the importance of asymptomatic S. pyogenes carriage and of S. pyogenes skin infections in young children.


SpyCATS uncovered that children under five bear the greatest burden of Streptococcus pyogenes disease in The Gambia in the form of pyoderma (Image 1 – Study Design and Image 2 – SpyCATS field team). Notably, the study revealed that skin infections play a crucial role in the transmission of the bacteria. Concurrently, the investigation into baseline IgG titres to key conserved S. pyogenes antigens demonstrated a rapid increase in antibodies during the first five years of life, suggesting that early exposure to the pathogen is important in shaping the immune response. 
Image 1 - Study Design
Image 2 - SpyCATS Field Team
The MRC Unit's commitment to tackling S. pyogenes continues with funding from the Leducq Foundation. As part of the iSpy LIFE network they will conduct a school-based cohort study that will further explore the mechanisms of natural immunity including cell-mediated responses. The MRC Unit The Gambia, through this work, continues to contribute invaluable data and insights, reinforcing its position as a centre of excellence in infectious disease research in Africa. More information about the SpyCATS cohort study, and its findings, can be found here.
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