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CeZAP Monthly Thematic Area socials are coming in 2022!
Come gather with the CeZAP community at our monthly Thematic Area Socials. A different thematic area will be highlighted each month, but the socials are open to the entire CeZAP community. These socials will be an informal gathering for the CeZAP community, but also provide an opportunity for faculty, post-docs and/or students to give 3-5 minute talks about their research (within the “theme of the month”). These talks can serve to strengthen communication skills and/or facilitate collaborations. The day and time of the socials will rotate each month to accommodate the majority of people’s schedules. Lunch or snacks will be provided.
 
January CeZAP Thematic Social
"Pathogen Identification and Disease Diagnostic"
Tues, January 24th
12:30 - 1:30
ILSB 1040 and lobby area
Lunch will be provided
Contact Boris Vinatzer <vinatzer@vt.edu> or Sarah Gouger <sgouger@vt.edu> for more information. Check out our website for more information on the Thematic Research Areas HERE
Virginia Tech researcher receives $1.9 million NIH grant to develop novel approaches to diagnose and treat sepsis 

Nearly 1.7 million adults in the U.S. develop sepsis, and a quarter of that number die from the infection, according to the National Institute of General Medical Sciences. Some infections cannot be resolved by general antibiotics because of strains of bacteria mutating, making it a challenge to provide adequate treatment.

Juhong Chen, assistant professor of biological systems engineering in the College of Agriculture and Life Sciences and College of Engineering, recently received a National Institutes of Health (NIH) grant to develop novel phage- and CRISPR-based approaches to detect and treat sepsis, including hybrid bio-inorganic nanobots, CRISPR-based devices, and CRISPR-quipped engineered phages. Chen and his research group also aim to address challenges for the detection of sepsis-related pathogens in blood samples. Chen’s research could lead to formulating a revolutionary strategy to diagnose sepsis in blood samples in the future. READ MORE>>

Virginia Tech researchers will investigate how bird feeding influences humans and birds

Ashley Dayer of the College of Natural Resources and Environment, the lead principal investigator on the project, and Dana Hawley, a co-principal investigator from the College of Science, are leading a team that has received a $1.6 million grant from the National Science Foundation (NSF) to study human-wildlife interactions through bird feeding.

“With this study, we will be able to explore how to maximize benefits to wildlife and humans in a dynamic system,” Dayer said. “Importantly, we aim to shed light on questions wildlife agencies are asking about how to address avian disease outbreaks.

In addition, Hawley and a graduate student will be looking at ways to stop the spread of a pathogen causing conjunctivitis in birds, an illness that resembles pink eye. House finches seem particularly vulnerable.  
READ MORE>>

Fee waiver for ID IGEP applicants

Thanks to everyone for their efforts to help increase the size of the Infectious Disease (ID) IGEP applicant pool this academic year!  With increasing ID IGEP application number trends, right now, we don't anticipate putting out a call for fellowship nominees from faculty in the spring as we've done the past two years. 
 
Therefore, if you have graduate applicants that you are trying to recruit and you want them to be considered for ID IGEP fellowship support during their first academic year, we are requesting that the students be encouraged to simultaneously apply to the ID IGEP.  We will waive the second application fee for these students to facilitate this process.

If the student is indicating a strong preference for a specific PI member of ID IGEP during the application and interview process then their rotations would be considered "supporting" rotations that would enable them to gain critical skill sets and build collaborations to support the work they will do in their primary lab. If a student is undecided on a specific PI, then they will complete three exploratory rotations prior to committing to one lab. In order for the ID IGEP to build a successful case for a future training grant that will benefit us all, it is vital that we increase the number of direct ID IGEP applicants. We believe that this mechanism will facilitate progress towards that goal. The immediate benefit to both PI and student is the possibility of obtaining 9 months of ID IGEP fellowship support. Thank you for your consideration and support.

Help us advertise the ID IGEP program and recruit students

Please consider showing this slide at the end of any upcoming conference presentations and /or in any undergraduate classes you are teaching. 
ID IGEP Powerpoint Slide - Click here to download
Recent Publications by CeZAP Affiliated Faculty
Feasibility of polyclonal avian immunoglobulins (IgY) as prophylaxis against human norovirus infection Artman C, Idegwu N, Brumfield KD, Lai K, Hauta S, Falzarano D, Parreño V, Yuan L, Geyer JD, Goepp JG Viruses DOI: 10.3390/v14112371

North American House Sparrows Are Competent for Usutu Virus Transmission. Kuchinsky SC, Marano J, Hawks SA, Loessberg E, Honaker CF, Siegel PB, Lahondère C, LeRoith T, Weger-Lucarelli J, Duggal NK. mSphere. 
DOI: 10.1128/msphere.00295-22

Leveraging a Fluorescent Fatty Acid Probe to Discover Cell-Permeable Inhibitors of Plasmodium falciparum Glycerolipid Biosynthesis Dapper C, Liu J, Klemba M. MIcrobiol SpectrDOI: 10.1128/spectrum.02456-22

Steelhead trout (Oncorhynchus mykiss) fed probiotic during the earliest developmental stages have enhanced growth rates and intestinal microbiome bacterial diversity Hines IS, Santiago-Morales, KD, Ferguson CS, Clarington J, Thompson M, Rauschenbach M, Levine U, Drahos D, Aylward FO, Smith SA, Kuhn DD, Stevens AM. Front. Mar. Sci. DOI: 10.3389/fmars.2022.1021647

Land cover and community water system characteristics as predictors of Safe Drinking Water Act violations in Central Appalachia, USA7. Smith E, Krometis LH, Czuba JA, Kolivras K. Sci Total Environ.  
DOI: 10.1016/j.scitotenv.2022.159726


Antimicrobial Resistance in the Environment: Informing Policy and Practice to Prevent the Spread. Pruden A. Environ Sci Technol DOI: 10.1021/acs.est.2c07503

Comparative genomics of Lactobacillaceae from the gut of honey bees, Apis mellifera, from the Eastern US. Bradford EL, Wax N, Bueren EK, Walke JB, Fell R, Belden LK, Haak DC. G3 (Bethesda)DOI: 10.1093/g3journal/jkac286

Phosphine-catalyzed regio- and stereo-selective hydroboration of ynamides to (Z)-β-borylenamides. Jos S, Tan C, Thilmany P, Saadane A, Slebodnick C, Evano G, Santos WL. Chem Commun (Camb)
DOI: 10.1039/d2cc04543e

 
Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues. Pashikanti S, Foster DJ, Kharel Y, Brown AM, Bevan DR, Lynch KR, Santos WL.  ACS Bio Med Chem Au DOI: 10.1021/acsbiomedchemau.2c00017

Muscarinic acetylcholine receptor activation synergizes the knockdown and toxicity of GABA-gated chloride channel insecticides Xie N, Gross AD. Pest Manag Sci  DOI: 10.1002/ps.7079

Host movement, transmission hot spots, and vector-borne disease dynamics on spatial networks. Saucedo O, Tien JH. Infectious Disease Modeling DOI: 10.48550/arXiv.2204.07678

Enhanced Fusobacterium nucleatum Genetics Using Host DNA Methyltransferases To Bypass Restriction-Modification SystemsUmaña A, Nguyen TTD, Sanders BE, Williams KJ, Wozniak B, Slade DJ. J Bacteriol  DOI: 10.1128/jb.00279-22

Kinetic and Structural Characterization of a Flavin-Dependent Putrescine N-Hydroxlayse from Acinetobacter baumanni Lyon N, Bogner A, Tanner J, Sobrado P. Biochemistry DOI: 10.1021/acs.biochem.2c00493

First isolation of Carnobacterium maltaromaticum from farmed rainbow trout Oncorhynchus mykiss in Virginia. Smith, S.A., S.J. Newman, C.E. Harrison, Loch TP  J Aquat Anim Health 
DOI: 10.1002/aah.10176


Development of a controlled laboratory-scale inoculation system to study Vibrio parahaemolyticus-oyster interactions. Hines, I., Smith, S.A., Kuhn, DD, Stevens, A. FEMS Microbiol Lett. DOI: 10.1093/femsle/fnac055

Phage Predation Promotes Filamentous Bacterium Piscinibacter Colonization and Improves Structural and Hydraulic Stability of Microbial Aggregates.Yu Z, Chen J, Tan Y, Shen Y, Zhu L, Yu P. Environ Sci Technol. DOI: 10.1021/acs.est.2c04745

Demonstrating a Comprehensive Wastewater-Based Surveillance Approach That Differentiates Globally Sourced Resistomes. Prieto Riquelme MV, Garner E, Gupta S, Metch J, Zhu N, Blair MF, Arango-Argoty G, Maile-Moskowitz A, Li AD, Flach CF, Aga DS, Nambi IM, Larsson DGJ, Bürgmann H, Zhang T, Pruden A, Vikesland PJ. Environ Sci Technol. DOI: 10.1021/acs.est.1c08673
Recent Research Grant Awards by CeZAP Affiliated Faculty
 
  • DTRA (HDTRA1-1-23-0009 "Comparative analysis of TBI, OPNA, and encephalitic alphaviruses as a path to neuroprotective therapeutics"
    • PI: Kylene Kehn-Hall, Co-PI: Hehaung (David) Xie and Michelle Theus
Summary of Grant: Research on encephalitic alphaviruses (Venezuelan, eastern, and western equine encephalitis viruses – VEEV, EEEV and WEEV) and organophosphate nerve agents (OPNA) pathogenesis is limited, but information can be gleaned by a comparative analysis with other intensively studied neuropathologies such as traumatic brain injury (TBI). One notable commonality between TBI, OPNA and encephalitic alphaviruses infection is the occurrence of seizures. We hypothesize that neuronal injuries induced through TBI, OPNA, and encephalitic alphavirus infection have common molecular and pathologic characteristics that can be leveraged to develop medical countermeasures for encephalitic alphavirus and OPNA neuropathologies and sequelae. The primary goals of this work are: 1. Creation of a comparative neuropathology database, 2. Identification of common molecular characteristics of neuropathology induced by TBI, OPNA, and encephalitic alphaviruses, and 3. Identification of therapeutics that may potentially reduce OPNA and/or encephalitic alphavirus neuropathologies.
 
  • 2023 PhRMA Foundation Award postdoctoral fellowship
    • Rogerio Bataglioli, Bryan Hsu lab
  • Department of Health and Human Sciences and the Steven and Alexandra Cohen Foundation
    • Brandon Jutras, Richard Helm and Marcos Pires (University of Virginia)
    • $100,000 for Phase 1 in the LyneX Diagnostics Prize and exclusively invited to participate in Phase 2, anticipated to begin in early 2023 and compete for a share of the $2 Mil total prize pool
Southwest Virginia lab switches focus from COVID testing to genomic sequencing

Since April 2020, the Virginia Tech COVID-19 lab has processed more than 220,000 samples. The lab’s director is Carla Finkielstein, a professor at the Fralin Biomedical Research Institute at VTC. As more people have become vaccinated against COVID-19, testing for the virus isn’t as frequent. As COVID vaccines and at-home tests have become more accessible, labs across the country have shifted focus from COVID testing to genomic sequencing to stay ahead of the curve. READ MORE>>

COVID-19 Outreach by CeZAP Affiliated Faculty
Outreach activities by CeZAP Affiliated Faculty
 
Cassidy Rist delivered an oral presentation at the annual meeting for the American Society for Tropical Medicine and Hygiene, Seattle, Washington.
 
Rist C., Assenga A., Sale M., et al.  (2022, November 2)Food safety and economic implications of ivermectin mass drug administration in swine – a One Health perspective on the future of malaria vector control 

To Foster and Promote a Cohesive and Synergistic Environment for Interdisciplinary and Collaborative Research







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