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CARIM Newsletter March 2023

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This newsletter contains information on the following subjects:
  • CARIM Courses
  • Grant DHF, BHF and DZHK CARIM researchers
  • Workshop Science Communication
  • Crowdfunding Workshop
  • CARIM HS-BAFTAs call May 2023
  • Coaches for senior PhDs
  • Kootstra Talent Fellowships
  • Hybrid ablation: a team effort with better outcome
  • DCVA Steer your Career Training Program
  • MYA career fair
  • Open Science Survey
  • Who's New?!
  • NeuroMind Academy
  • Paramount Papers
  • Cardiovascular Grand Rounds Maastricht
  • Academic Events
  • Lectures, symposia & events

CARIM newsletter


Contributions for the newsletter (e.g. news of events and grants, important publications, societial impact related topics and research results related to CARIM's research) can be sent to CARIM-office@maastrichtuniversity.nl. Please submit the text in English and include a short title. The text should be max. 200 words. If applicable, include high resolution pictures and other documents.
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CARIM Courses - June 2023


This year, the CARIM Courses are scheduled in two weeks: week 1 from 12-16 June and week 2 from 19-23 June.
Please, mark these dates in your agenda already!
 
The CARIM Courses allow you to get acquainted with state-of–the-art technologies and novel concepts in cardiovascular research. Equally important, it allows you to meet fellow-PhDs and CARIM staff. This will help you to generate new ideas, to boost your own research, and to enlarge your network.
 
The topics of the courses of this year are:
As always, as part of the course week I’MCARIM will organise a social event in one of the evenings of the first week (12-16 June) for all course participants. On Wednesday afternoon on 21 June, a workshop will be organised for all CARIM PhD candidates.
 
Please remember that as part of your PhD trajectory you are required to participate in at least two CARIM courses.
 
Registration will open on Wednesday 30 March. At that moment more details about the topics covered by each course and the general program will be distributed.

Grant DHF, BHF and DZHK awarded to CARIM researchers

Dr Judith Cosemans, Dr Rory Koenen (Dept of Biochemistry) and Prof. Blanche Schroen (Dept. of Physiology), together with their colleagues from the University of Edinburg and the Ludwig Maximilian University of Munich received a grant from the Dutch Heart Foundation together with the British Heart Foundation (BHF) and the DZHK Deutsches Zentrum für Herz-Kreislauf-Forschung e. V. for their MegaCardiocyte project.

In total €5.3 million over four years was awarded to four international teams to discover new ways to treat different types of heart failure, tackle atherosclerosis – the leading cause of heart attacks and strokes – and deep-dive into thousands of proteins to ultimately give doctors even better risk prediction and management tools. The funding builds on the success of three previous rounds of the funders’ partnership, with this round specifically designed to support mid-career researchers.

MegaCardiocyte - Mapping a blood-bone marrow-heart axis to identify new drug targets for heart failure
Heart failure is a debilitating and progressive disease that has no cure and is often fatal. For a particular type of heart failure which arises from an impaired ability of the heart’s chambers to relax between beats, abnormal function of small blood vessels is likely to be an important triggering factor. The MegaCardiocyte consortium will explore the link between small blood vessel function and that type of heart failure. They suspect it might be attributed to malfunctioning blood platelets – normally responsible for clotting – that, together with an overactivation of immune cells in the blood, compromise the ability of small blood vessels in the heart to work normally. The work may lead to the development of platelet-targeted treatments in the prevention and management of heart failure.

The project builds on work that was supported by the CARIM PhD call round of 2019.

Workshop Science Communication


Have you ever wondered why we should communicate about science and what the benefits are for you?
 

You will get the answers to these questions, and more during our science communication workshop.
 
Together with the Marketing & Communication departments of FHML and Maastricht UMC+, CARIM organises a workshop “Science Communication” on Tuesday 28 March from 12.00 – 14.00 hours in the Ballroom, Dept. of Biochemistry (lunch is included).
 
To make the workshop specific for you, it would be nice if you could tell us where the needs are. For example, do you want to know how to translate research into understandable language, how to use social media to share your research, when to seek out the press/how to deal with the press, etc.? Just let us know and we will tailor the workshop accordingly!
 
Please register for the workshop before Monday 13 March by sending an e-mail to CARIM-office@maastrichtuniversity.nl Should you have specific goals regarding science communication please let us know.
 
For our other workshops and events in 2023 please have a look at UMployee CARIM. For the PhD candidates, a workshop will be organised during the CARIM Course Week in June. If you don't participate in the Course Week in JUne, feel free to register for this workshop!

 

Crowdfunding workshop | How to create a successful campaign?


When: Tuesday 11 April 2023, 12:00-13:00 (Including lunch)
Where: UM | Ballroom Biochemistry | H1.327A

Do you like to explore innovative and alternative ways for funding? And do you want to generate exposure for your research goals and extend your network too? Then, crowdfunding might be a suitable mean to realise your ambition. Since 2019 University Fund Limburg/SWOL has started crowdfunding platform www.umcrowd.nl. By means of this platform UM staff members and students, in cooperation with the Fund, can set up crowdfunding campaigns on behalf of concrete, tangible and societal (research) projects within UM. In the past, several successful CARIM crowdfunding campaigns have been realised, for example the campaigns of Rogier Veltrop and Chahinda Ghossein on cardiovascular disease.

But how can you achieve a successful campaign? And what are important lessons learned from previous campaigns? In this workshop Guido Vanderbroeck, Senior Advisor of the University Fund Limburg/SWOL, will give a general introduction on crowdfunding and tips & tricks to launch a successful campaign.

Please register before 27 March via secretariaat-carim@maastrichtuniversity.nl

CARIM HS-BAFTAs - Deadline 1 May 2023


Early recognition of talent is one of the key strategies of CARIM to coach and prepare gifted young academics for their future academic career. CARIM stimulates and supports talented students and staff by offering grants for research programmes at each step of their career, be it at Bachelor, Master, post graduate, PhD or postdoc level. These grants will be enabled through our ‘Harry Struijker-Boudier award for talented academics’ (HS-BAFTA). The HS-BAFTA programme is intended for three groups of young scientific researchers.
 
1. HS-BAFTA Talented future PhD candidates
2. HS-BAFTA Talented PhD candidates
3. HS-BAFTA Talented postdocs
 
Please click on the category for the calls, procedures and application forms for each category.
Deadline: 1 May 2023

Coaches for senior PhD candidates

 
All CARIM PhD candidates that recently started have been allocated with a coach. The coaching system is meant to allow PhD candidates to openly discuss non-scientific issues and professional relations with a CARIM staff member not directly involved in the daily research activities of the PhD candidate. More information about the coaching system can be found here.

Some of the senior PhD candidates indicated that they would also appreciate a coach. If you are a senior CARIM PhD candidate that would like to be connected with a coach, you can contact the CARIM office: secretariaat-CARIM@maastrichtuniversity.nl

Kootstra Talent Fellowships

We are pleased to inform you that the call for the 'Kootstra Talent Fellowship (KTF)', round Spring 2023 is open. The application deadline is 1 April 2023.

The KTF aims to facilitate talented researchers to develop their own research ideas and CV, and subsequently help increase their chances of obtaining personal grants at external funding agencies. Therefore, the fellowship should be, amongst other things, be used to apply for personal grants such as Veni, Marie Curie, and Rubicon.

The call is open to:
  1. researchers who obtained their PhD degree at the FHML of Maastricht University within one year of the application deadline, or
  2. researchers who are finalizing their PhD at the FHML of Maastricht University.
For more information regarding the KTF, see attachments below or contact Marco Berndes, funding advisor FHML, m.berndes@maastrichtuniversity.nl.

Please arrange to have your principal investigator confirm his willingness and ability to provide the 50% matching. CARIM will provide you with a supporting letter if this willingness is confirmed by mail. 
Without this letter your application is not eligible. If you need support regarding your application, please contact CARIM's funding advisor Gwynned de Looijer.

Guidebook Kootstra applications
Application format Kootstra Talent Fellowship (KTF) - Spring 2023
Narrative CV format Kootstra Talent Fellowship (KTF) - Spring 2023
Call for proposals / procedure

Hybrid ablation: a team effort with better outcomes


The hybrid ablation treatment developed at Maastricht UMC+ leads to better results in persistent atrial fibrillation than the standard treatment, catheter ablation. About twice as many patients have no complaints after a year. In addition, the quality of life after one year is the same with both treatments, despite the fact that the hybrid ablation is a more serious procedure and requires more recovery time.

The research team, led by heart surgeon Bart Maesen and cardiologist Justin Luermans recently published the results in the scientific journal JACC: Clinical Electrophysiology.



 

DCVA Steer your Career Training Program

Are you a senior PhD student or early Postdoc? Do you wonder about your next career move?

Young@Heart and DCVA team up with ttopstart to offer you the “DCVA Steer your Career Training Program”. We offer unique one-on-one coaching to give you personalized career advice, teach you how to successful write grants and how to find funding opportunities. You will connect to professionals inside and outside academia to broaden your network and obtain individualized career advice.

The “DCVA Steer your Career Training Program” supports young scientists to take control over their careers! We will select 15 candidates soon, please send in your CV, motivation and support letter to talent@dcvalliance.nl no later than 13 March 2023. Check the DCVA and Young@Heart websites for more information and apply now! 

Maastricht Young Academy career fair for health and life sciences


Are you looking for a new job but have no clue what positions are out there?
Then come join us for this unique initiative organized by the Maastricht Young Academy!
After short pitches on non-academic positions in the university/hospital/industry, you will have the chance to further discuss and network with our speakers. The Staff Career Center will also be present to give professional feedback on CVs.
 
When? 30th March 16:00-19:00 
Where? Greepzaal, 4th floor, MUMC+
 
Programme:
16:00-17:30: pitches about positions
17:30-19:00: possibility to further discuss with our presenters around drinks and nibbles + get feedback on your CV
 
Sign up HERE
 
Registrations for the CV feedback will be done at the beginning of the event on a first come first serve basis.

Organizers: Aurore Lyon, Veerle Melotte, and Berta Cillero-Pastor, on behalf of the Maastricht Young Academy and MERLN.
Feel free to contact a.lyon@maastrichtuniversity.nl if you have any questions.

Open Science Survey


The FHML Open Science Team would like to extend a warm invitation to participate in a survey aimed at gathering information on your experiences with Open Science. The survey is designed to take approximately 15 minutes to complete and will provide us with valuable insights into the current state of Open Science at FHML/Maastricht UMC+.

Open science is a movement that focuses on making research more transparent, accessible, and reproducible, and is quickly becoming the norm in the scientific landscape. It encompasses a wide range of practices, from open data sharing to pre-registering study designs, and has the potential to enhance the quality and impact of scientific research greatly.

You are at the forefront of this movement, and your experiences and perspectives are essential to shaping the future of Open Science at FHML/Maastricht UMC+. The survey therefore aims to gather information on your current practices, your views on open science, and the challenges you have faced in implementing open science practices in your work. The team will subsequently use this information to draft the FHML Open Science Action Plan.

Your participation in this survey is greatly appreciated, and our team would like to thank you in advance for taking the time to share your experiences and perspectives. We would like to point out that the survey is completely confidential.

To participate in the survey, simply click on the following link. If you have any questions or concerns, please do not hesitate to contact us.

Thank you for considering our invitation. We look forward to your participation and are eager to hear about your experiences with Open Science.

Kind regards,

The FHML Open Science Team (Dennie HebelsOlav Palmen and Merlijn Meens)

Who's new?!





























 

NeuroMind Academy


NeuroMind Academy offers carbon neutral online microlearning aimed at healthcare professionals, both caregivers and scientific staff. It is a service provided by DecisiX, a startup in the Brightlands Maastricht Health Campus, led by Pieter Kubben.
 
The first course modules focus on increasing digital literacy and cover topics such as clinical data science, machine learning, and artificial intelligence. These courses are offered in a graphic style and provide a framework to better understand this increasingly important topic. No prior knowledge of this topic is required.
 
The complete bundle can be completed in 2-3h in total. You can sign up on https://neuromind.academy/bundle/clinical-data-science-essentials .
 
CARIM employees can follow this course bundle free of charge by requesting a coupon code from pieter@decisix.nl . The coupon will waive the course fee allowing permanent access to the full bundle. Do mention your CARIM affiliation explicitly when requesting the coupon and put carim-office@maastrichtuniversity.nl in the cc of your email please.

Paramount Papers

Blood Milieu in Acute Myocardial Infarction Reprograms Human Macrophages for Trauma Repair

Acute myocardial infarction (AMI) impacts on the whole body, including blood composition. We addressed whether macrophages, key players in trauma repair, sense and respond to these changes. Human monocyte-derived macrophages were exposed to human AMI or control serum. Transcriptional and multiparameter functional screening revealed an overt AMI signature, enriched in debris cleaning, mitosis, and immune pathways. Moreover, we identified gene networks associated with AMI and with poor clinical prognosis in AMI. Network-guided drug screening on the latter unveiled PGE2 signaling as target for clinical intervention in detrimental macrophage imprinting during AMI trauma healing. Our results demonstrate pronounced context-induced macrophage reprogramming by the AMI systemic environment, to a degree decisive for patient prognosis. This offers new opportunities for targeted intervention and optimized cardiovascular disease risk management.

Fontaine MAC, Jin H, Gagliardi M, Rousch M, Wijnands E, Stoll M, Li X, Schurgers L, Reutelingsperger C, Schalkwijk C, van den Akker NMS, Molin DGM, Gullestad L, Eritsland J, Hoffman P, Skjelland M, Andersen GØ, Aukrust P, Karel J, Smirnov E, Halvorsen B, Temmerman L, Biessen EAL. Blood Milieu in Acute Myocardial Infarction Reprograms Human Macrophages for Trauma Repair. Adv Sci (Weinh). 2022 Dec 16:e2203053. doi: 10.1002/advs.202203053. Epub ahead of print. PMID: 36526599.

Click here for the full article.

Cardiovascular Grand Rounds Maastricht


10 March - Koen Reesink, PhD, Maastricht UMC+
'Vascular system dynamics'

24 March - Ehsan Natour, MD, PHD, Maastricht UMC+
'When life comes to a standstill - A scientific analysis of the patient journey'


8.00-9.00 AM online and on-site

ZOOM-link for all meetings:
https://maastrichtuniversity.zoom.us/j/97224872025?pwd=Q0dwWEc1SzA0T0c1U1FZeUQvSDRvUT09
 
Meeting ID: 972 2487 2025
Password: 678252

Click here for the upcoming lectures.


The steering committee for the Cardiovascular Grand Rounds consists of CARIM staff members of the 3 divisions (Heart, Vessels and Blood) and includes Renske Olie, Sébastien Foulquier, Pieter Goossens, Jordi Heijman, Rory Koenen, Blanche Schroen, Julie Staals and Kristiaan Wouters. If you have suggestions for a specific topic or speaker, please contact any of the committee members and they will assist in scheduling the lecture with you.

Academic Events


PhD conferral Camilla Soragni, 2 March, 10.00 hours, MBB 4-6
Supervisors: Prof. L.J. de Windt, Prof. P.A. da Costa Martins
Co-supervisor: Dr C. Ping Ng (MIMETAS BV Oestgeest)
Title: Next stop: screening-on-a-chip. Where biology meets scalability Development of assays for placenta-on-a-chip models.
 
PhD conferral Alexandru Florea, 8 March, 16.00 hours, MBB 4-6
Supervisors: Prof. F.M. Mottaghy, Prof. M.E. Kooi, Prof. L.J. Schurgers
Co-supervisor: Prof. J. Bucerius (RWTH Aachen University)
Title: Sodium [18F]Fluoride positron emission tomography for non-invasive identification of micro-calcifications as marker of atherosclerotic plaque vulnerability

PhD conferral Nicolò Mangraviti, 13 March, 10,00 hours, MBB 4-6
Supervisors: Prof. L.J. de Windt, Prof. M. Stoll
Title: LncRNA Bigheart in cardiac disease and development

PhD conferral Renske Olie, 20 March, 13.00 hours, MBB 4-6
Supervisors: Prof. H. ten Cate, Prof. J.M. ten Berg
Co-supervisor: Dr P.E.J. van der Meijden
Title: Personalized antithrombotic treatment in high-risk patients with coronary artery disease

PhD conferral Isabella Provenzale, 28 March, 10.00 hours, MBB 4-6
Supervisors: Prof. J.W.M. Heemskerk, Prof. J.M. Gibbins (University of Reading, UK)
Co-supervisors: Dr P.E.J. van der Meijden, Dr C.I. Jones (University of Reading, UK)
Title: The modulatory roles of collagen and endothelial cells on platelet function

PhD conferral Pieter Glerum, 29 March, 13.00 hours, MBB 4-6
Supervisors: Prof. C. Neef, Prof. D.M. Burger (Radboud University)
Co-supervisor: Dr M. Maliepaard (College ter beoordeling van geneesmiddelen, Utrecht)
title: "Generic interchangeability: between science and regulation"


All PhD defences can be followed online as well via https://phd-defence.maastrichtuniversity.nl/


Upcoming inaugural lectures

Prof. Judith Sluimer
17 May, 16.30 hours 
Title: “A breath of fresh air in cardiovascular research”

Lectures, symposia & events


Cardiorenal Seminar - Jaap van Buul - 16 March 12.30 hour 
Euro-BioImaging User Forum: Cardiovascular Research - 21 March 2023
Microscopy CORE Lab Ambassadors day - 23 March

European Society for Microcirculation Conference 2023 -  24-27 April 2023
Genetics Retreat - 4 & 5 May 2023
EVBO Summer School - 5-7 July 2023 
28th Congress of the European Society of Biomechanics - 9-12 July 2023


Upcoming School Council meetings:
11 May: 13.00-15.00h
12 October: 13.00-15.00h

KNAW agenda
Brightlands news

Media Moments


https://bit.ly/3kzqDzc 27/2 Op de derde verjaardag van de allereerste bevestigde corona-infectie in Nederland waarschuwen wetenschappers dat de weinige onderzoeken naar long covid stil kunnen komen te liggen of vertraging oplopen. De financiering voor de salarissen van onderzoekers is niet goed geregeld. Daarom stappen jonge wetenschappers met zeldzame kennis over long covid soms over naar andere projecten. Chahinda Ghossein (CARIM/ FHML) praat erover in het NOS Radio 1 Journaal (https://bit.ly/3IZKT6q),

https://bit.ly/3xXXnW4 Ook het tv-programma Limburg Centraal op de regionale zender L1 liet de twee Maastrichtse onderzoekers aan het woord. Ghossein kwam eveneens aan het woord in een artikel op de website van Omroep Brabant. Dagblad De Limburger wijdde een hoofdredactioneel commentaar aan de kwestie (https://bit.ly/3IXSUbX).


https://bit.ly/3K1gJkn 2/2 Fastfoodketens nestelen zich bij voorkeur in arme wijken. Gemeenten zoeken naar middelen om ze te weren met het oog op de volksgezondheid. Maar hoe kun je bewijzen dat het door fastfood - ultrabewerkt voedsel met veel zout, suiker en verzadigd vet - komt dat mensen dik worden? Martijn Brouwers (CARIM/ FHML) geeft antwoord in een artikel voor NRC Handelsblad.

https://bit.ly/3DKgeHa 2/2 Op de spoedeisende-hulpafdelingen van 38 ziekenhuizen verspreid over Nederland vond afgelopen week een zogenoemd flashmob onderzoek plaats, onder leiding van het Maastricht UMC+ en het LUMC. Mensen die op de spoedeisende hulp (SEH) binnenkwamen, werd gevraagd wat ze vinden van thuismonitoring. Het Algemeen Dagblad schreef over het initiatief en liet daarbij ook Patricia Stassen (FHML) aan het woord.
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