Annual CARIM Symposium 2023 - Save the date!

It is with great joy that we announce the date of our annual CARIM symposium. 

This year our CARIM symposium will take place on Wednesday 29 November 2023 at the Minderbroedersberg 4-6 - Save the date! 

This year's Robert Reneman Lecture will be given by Mary Cushman, hematologist at the University of Vermont Medical Center and a professor of medicine and pathology at the Larner College of Medicine at UVM in Burlington, VT.

Junior Fellowship Philippe Vangrieken

Harry Crijns Research Grant

De Harry Crijns Research Grant, in het leven geroepen door het Hart en vaat onderzoekfonds Limburg,  in te stelle wordt periodiek toegekend aan jonge wetenschappers die zich bezighouden met klinisch cardiovasculair onderzoek en daarmee bijdragen aan de realisering van de doelstellingen van de foundation.

Prof. dr. Harry J.G.M. Crijns was tot December 2020 voorzitter van de vakgroep cardiologie van het Maastricht UMC+ en bestuurslid van CARIM. Gedurende zijn lange en succesvolle carrière in de translationele en klinische cardiologie heeft Prof. Crijns ontelbare bijdragen geleverd aan de cardiovasculaire wetenschap, in het bijzonder op het gebied van atriumfibrilleren. Hij heeft een belangrijke rol gespeeld in de vormgeving van cardiovasculaire research op lokaal, nationaal en Europees niveau en heeft een grote impact gehad op de carrières van vele assistenten en collega’s en op de levens van vele patiënten en hun naasten.

Hart en vaat onderzoekfonds Limburg, onderdeel van Health Foundation Limburg, heeft dan ook besloten om een Harry Crijns Research Grant in te stellen. Deze grant ten bedrage van € 25.000 wordt periodiek toegekend aan jonge wetenschappers die zich bezighouden met klinisch cardiovasculair onderzoek en daarmee bijdragen aan de realisering van de doelstellingen van onze foundation.

Download hieronder de informatie over hoe u een aanvraag kunt indienen.
Let op: indienen vóór 18 september 2023.

Aanvraagformulier Harry Crijns Research Grant

Voorwaarden Harry Crijns Research Grant

Cycle along for cardiovascular research in Limburg

Sporty CARIM members wanted who love cycling and like to get on the pedals - together with their cardiologist - to raise money for groundbreaking research into cardiovascular diseases at Maastricht UMC+.

On Thursday evening - June 8, 2023 - we will start at 6 p.m. from Geulle (municipality of Meerssen) with several rounds of 20 km. can be driven. You can get out after each round or decide to continue.

Bicycle: Road bike or mountain bike (electric assistance is allowed, speed pedelecs are not allowed).

Fitness Requirements: You are able to cycle an average of 20 km/h and have covered the necessary kilometers in the past year.

Safety: A support vehicle is provided and there is first aid support.

Max. number of participants: 40 including participating physicians.

Get sponsored: We ask participants to do their utmost to collect an amount of € 500 via this website. Register with one of the teams and share your campaign page with friends, family and colleagues via Whatsapp, e-mail, LinkedIn, Facebook, etc. You will succeed in raising this amount. Friends and family appreciate it if you are sporting for this good cause and will certainly support you!

Register with one of the team captains:
Check the teams on the teams page at www.fietsmetjedokter.nl, go to 'I'm cycling along' and choose your team when registering. We will also reserve a number of places for sports enthusiasts who are not heart patients but do care about the cause.

Join the YUFE Training Programme for PhD Supervisors

For the three days online workshop/training for beginning PhD supervisors during fall 2023 
By Prof. Ronit Shiri Sverdlov and Dr Jan Theys, Maastricht University

PhD supervision is a core activity in an academic career. The aim of this training is to provide PhD supervisors with tools for recognizing, identifying and supporting young talents. Supervisors will learn how to foster self-development and self-reflection in young talents and will receive a platform for sharing experiences and best practices among peers in different fields and different universities.

The training will include three workshop days. Each workshop day consist of an input part and an InterVision part, in which supervisors will exchange about their experiences with supervision and discuss specific cases among each other. The workshops will be interactive and take part in an international setting, as supervisors from all YUFE universities can take part. 

Programme details:

• Thursdays, 28 September 2023: “Supervisor profiles, diversity in students and managing expectations”
• Thursdays, 19 October 2023: “Reflection and learning goals”
• Thursdays, 09 November 2023: “Actionable feedback”

NPO procedure

Paramount Papers

Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens

Expansion microscopy physically enlarges biological specimens to achieve nanoscale resolution using diffraction-limited microscopy systems. However, optimal performance is usually reached using laser-based systems (for example, confocal microscopy), restricting its broad applicability in clinical pathology, as most centres have access only to light-emitting diode (LED)-based widefield systems. As a possible alternative, a computational method for image resolution enhancement, namely, super-resolution radial fluctuations (SRRF), has recently been developed. However, this method has not been explored in pathology specimens to date, because on its own, it does not achieve sufficient resolution for routine clinical use. Here, we report expansion-enhanced super-resolution radial fluctuations (ExSRRF), a simple, robust, scalable and accessible workflow that provides a resolution of up to 25 nm using LED-based widefield microscopy. ExSRRF enables molecular profiling of subcellular structures from archival formalin-fixed paraffin-embedded tissues in complex clinical and experimental specimens, including ischaemic, degenerative, neoplastic, genetic and immune-mediated disorders. Furthermore, as examples of its potential application to experimental and clinical pathology, we show that ExSRRF can be used to identify and quantify classical features of endoplasmic reticulum stress in the murine ischaemic kidney and diagnostic ultrastructural features in human kidney biopsies.

Kylies D, Zimmermann M, Haas F, Schwerk M, Kuehl M, Brehler M, Czogalla J, Hernandez LC, Konczalla L, Okabayashi Y, Menzel J, Edenhofer I, Mezher S, Aypek H, Dumoulin B, Wu H, Hofmann S, Kretz O, Wanner N, Tomas NM, Krasemann S, Glatzel M, Kuppe C, Kramann R, Banjanin B, Schneider RK, Urbschat C, Arck P, Gagliani N, van Zandvoort M, Wiech T, Grahammer F, Sáez PJ, Wong MN, Bonn S, Huber TB, Puelles VG. Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens. Nat Nanotechnol. 2023 Apr;18(4):336-342. doi: 10.1038/s41565-023-01328-z. Epub 2023 Apr 10. PMID: 37037895; PMCID: PMC10115634.

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