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🍁 Other connections Belzutifan (and Canada)
 
  Belzutifan research story U of T Canada, Apr.30/23 *with updated last paragraph in RED*

“The mechanism at play in von Hippel-Lindau syndrome … impacts how all cells sense and adapt to oxygen deprivation. ‘The worlds of hypoxia and VHL collided in that discovery…’”

-- Dr. Michael Ohh, Professor of Laboratory Medicine and Pathobiology and Biochemistry at the University of Toronto. U of T News, Nov.15/19. Our Canadian 'connection'!

“Professor Michael Ohh received his PhD from the University of British Columbia and was a… postdoctoral fellow in the…laboratory of William G. Kaelin Jr. at the Dana-Farber Cancer Institute and Harvard Medical School [in the 1990s]. Professor Ohh contributed to the pioneering work that defined the fundamental oxygen-sensing mechanism that governs metazoan cellular adaptation to changes in oxygen levels – a discovery that would lead to the recognition of his mentor W.G. Kaelin Jr. with the 2019 Nobel Prize

Professor Michael Ohh is recipient of the Canadian Cancer Society’s Bernard and Francine Dorval Prize, Premier’s Research Excellence Award, and Canada Research Chair in Molecular Oncology.”

Overall, “This is a great scientific story. It shows how studies of familial cancer and basic cell biology lead to effective new therapies that can directly benefit patients…” -1,2

The “Nobel” research included the hypoxia response which lead to Belzutifan: “The hypoxia response affects many aspects of physiology, including conditions such as anemia, cancer, stroke, infection and heart attack… The research is already leading to the development of new treatments…” -4



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1-NCI Support for Basic Science Paves Way for Kidney Cancer Drug Belzutifan. National Cancer Institute. January 25, 2022.

2 -Nobel Prize Award: Impact of Clinical Care? Ilene Sussman, December 13, 2019.

3 -Discovery of Molecular Switch for How Cells Use Oxygen Wins 2019 Nobel Prize in Medicine. Scientific American, October 7, 2019.
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